
Holiday rentals with lake access in Seneca
Find and book unique lake access rentals on Airbnb
Top-rated rentals with lake access in Seneca
Guests agree: these rentals with lake access are highly rated for location, cleanliness and more.

The Cobb Lake House
Looking for a Lake Hartwell getaway! This spacious lakefront home has room for everyone! Spend your mornings relaxing in the screened-in porch with a cup of coffee. Afternoons can be enjoyed down by the dock where you can sunbathe, kayak or just float around. Fish, dock your boat or jet ski. Public boat ramps are just a short drive away. Relax by the outdoor fire pit or enjoy the WOOD BURNING fireplace in the living room off a spacious kitchen and dining room. A great way to spend a vacation.

Peaceful Living Guest House on quiet cove
1st floor 2 bedrooms, bathroom walk-in shower, and kitchen. Loft family room, TV, Blue-Ray, comfortable furniture; card table, board games, & yoga mats. Access to private dock, gas grill, & outdoor furniture. Parking area 110'x37' up to two trucks w/boat trailers, 7 mi to Green Pond Landing & other access nearby. 20 min to Clemson, Southern Wesleyan University & Anderson University. Firepit, firewood & camp chairs available. EV Tesla’s universal charger. Washer-Dryer for weekly reservation only.

A-Frame Lake Hartwell Cottage w/ Hot Tub
No lake water till it substantially rains Lake Hartwell cottage w/ Hot Tub ! Clemson 9 mi. away! 2 bdrm, 2 full bath, hot-tub, canoe, 2kayaks, 🎣 poles, life-vests, dining & patio table, grill+charcoal, 3tv, Netflix/2DVDplayers/DVDs, kitchen, pots/pans, 2crockpot, microwave, dishwasher+pods, keurig+coffee, washer+detergent, dryer, spices, shampoo/cond, hair dryer, curler, straightener, linens, towels, 3bikes, helmet, Karaoke, firepit+wood, wall of fun! (Boat-landing 1 mi. away! Cateechee Shores

Waterfront cottage w/deep dock 17 miles to Clemson
Welcome to the Queen of Harts, our 2BR/1BA, waterfront cottage on Lake Hartwell w/private, deep water dock. The house is located on a quite street 25 min to Clemson. Interior has been remodeled including farmhouse kitchen sink, butcher block countertops, dishwasher, large bathroom, washer/dryer, and new furnishings. Enjoy beautiful sunsets on the dock or explore the cove on stand-up paddle boards included with rental. Other amenities include wi-fi, 55" Smart TV, charcoal grill, and fire pit.

Destination Keowee
A rustic industrial style Lake Keowee lakefront escape that places you right on a panoramic point in a private cove. Welcome the outdoors in with the 6ft kitchen hinge bar window to the upper deck or enjoy the 6-seat hot tub on lower deck. Deep water dock tie off space is available. Guests enjoy the use of 2 standup paddle boards, and lakeside fire pit (guest provide firewood). Great cove sunsets! 15 minutes to Clemson and 1 min Lighthouse Restaurant. Please read all details prior to booking!

Hartwell Hideaway – Dock, Kayaks & Fire Pit
The perfect home for lake lovers and college football fans. Located just ~5 minutes away from Clemson and Death Valley, the newly renovated lakefront cottage will be the perfect stay for you, your family, and friends. With an outdoor fire pit, amazing views, boat dock, kayaks, and a modern kitchen, this retreat has all the amenities you're looking for inside and out! Whether you spend your time relaxing at the house, cheering on the Tigers, or fishing the lake, the Hideaway is sure to please.

Beautiful Lake Keowee Condo with great Amenities
"Boasting lake views, a fully equipped kitchen, and resort-style amenities, this 2-bedroom, 2-bath Salem vacation rental condo in Keowee Key will have you experiencing the true meaning of life on the lake. Cool off with a dip in the community's outdoor pool which sits right next to the marina where you can rent a boat for a day out on the water. Tee up a round of golf on the renovated 18-hole course, walk along the trails of Oconee State Park, or catch a football game at Clemson University!"

Haven on the Lake-Entire downstairs, near Clemson
Beautiful setting on Lake Hartwell. Guests will have the entire downstairs which includes 2 bedrooms, bar area and entertainment area. Guests may bring their boat and dock it. There is plenty of room for trailer parking on premise and the boat ramp is less than 1/4 mile from house. Stay includes 2 hand thrown coffee mugs made by Purple Unicorn Pottery. Please note upstairs is private residence, hosts live there. TEMPORARILY CLOSED FOR COMPlETE REMODEL. SHOULD BE AVAILABLE MAY 2026.

Holliday's Inn Tiny Tree-house
Tiny Treehouse is a ‘container’ house set in a private wooded locale at the foothills of the mountains. Find yourself hiking at Oconee State park or Caesar's Head mountain along with a multitude of waterfalls within our county. 5 minutes from downtown historic Walhalla, 10 minutes to city of Seneca, and 20 minutes from Clemson University where tailgaters unite before the big football game! Explore the artistic venues and cultural scenes of Greenville just an hour away!

Lake Keowee Cabin: Peaceful and Bright
Welcome to Lizard Lodge. Relax in this quaint lake cabin with a mountain home vibe nestled in Northern Seneca on Lake Keowee. Enjoy the serenity of a beautifully modern 3-bedroom, 2.5 bath vacation cabin in a quiet gated cul-de-sac with scenic surroundings. On early mornings you can spot wildlife including deer and wild turkeys. Excellent location on the lake a few hundred feet away from a boat ramp. Come to relax, have fun on the lake or even enjoy a romantic escape.

Lakefront dock *hot tub* Anderson/Clemson king bed
Relax & enjoy the beautiful views of lake Hartwell from the front porch daybed swing, hot tub, or private dock. Sleep in a king size bed wrapped in cool cotton linens, a towel warmer, soaking tub with TV, & a breville espresso maker. Located w/i 10 minutes of many restaurants. Less than 20 min. to downtown Anderson Pendleton or Clemson. This prime location on lake Hartwell is a 10 minute boat ride to Portman Shoals Marina, the Galley restaurant, & Green Pond Landing.

Cozy Rustic Lakefront Cabin
“on the edge” is a small, cozy, rustic, lakefront cabin with easy walk to a private dock on Lake Hartwell. Great for fishing and swimming. Public boat ramp 2 miles. Living/dining area, two bedrooms. Relax on the large porch with swing and rocking chairs or enjoy fire pit area. No kitchen but includes microwave, full fridge, toaster, Keurig, coffee maker and gas grill. Perfect getaway but also near charming downtown Toccoa, Toccoa Falls, Currahee Mountain, hiking…..
Popular amenities for lake access rentals in Seneca
Lake access house rentals

Sweet Tea Retreats-Unsweetened B

Waterfall Cove - Prime

Cozy lakeside•HotTub•FencedYard 3 Dogs

Pete's Place

The Landing Spot

House on Lake Keowee swim beach in cove w/ Dock

A Travelers Nest ~ Lake House

Clemson Games + Lake Keowee
Apartment rentals with lake access

Lakeside Getaway

Captain Jack's on the Lake

Condo and Lake Keowee

TigerTown Tranquility | Lakeview Condo near Campus

Lake Hartwell - Hartwell Villa 8A

3BR Ground floor condo - 2.4 Miles to Death Valley

"Honeysuckle" Comforts of home in Mt. Wilderness

The Sugar Shack on Lake Keowee
Lake access cottage rentals

Lake Front Cottage/Floating Dock

The Blue Pine - A Cozy Updated Lakeside Cottage

Cottage on the Lake

South Cove Cottage ~ Lake Keowee

Winter Discount! Sunset Cottage Lake Hartwell

Lakefront cottage with a view, near Clemson

Lake Keowee Waterfront Cottage - Private Retreat

Cozy 3 Bedroom Cottage With Beautiful Lake Views!
Quick stats about holiday rentals with lake access in Seneca

Total holiday rentals
Explore 20 holiday rentals in Seneca

Nightly prices starting at
Seneca holiday rentals start at € 101 per night before taxes and fees

Verified guest reviews
Over 690 verified reviews to help you choose

Family-friendly holiday rentals
20 properties offer extra space & child-friendly amenities

Rentals with dedicated workspaces
10 properties have a dedicated workspace

Wifi availability
20 of Seneca holiday rentals include wifi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across Seneca rentals

4.9 Average rating
Seneca stays are highly rated by guests – averaging 4.9 out of 5!
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- Black Rock Mountain State Park
- Gorges State Park
- Table Rock State Park
- Ski Sapphire Valley
- Tallulah Gorge State Park
- Bell Mountain
- Helen Tubing & Waterpark
- Clemson University
- Jump Off Rock
- Anna Ruby Falls
- Carl Sandburg Home National Historic Site
- Fred W Symmes Chapel
- Chattooga Belle Farm
- Bon Secours Wellness Arena
- DuPont State Forest
- Looking Glass Falls
- Smithgall Woods State Park
- Devils Fork State Park
- Peace Center
- Paris Mountain State Park
- Greenville Zoo
- Falls Park On The Reedy
- Jones Gap State Park
- Soquee River




