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House holiday rentals in Seneca

Find and book unique houses on Airbnb

Quick stats about house rentals in Seneca

  • Total holiday rentals

    Explore 40 holiday rentals in Seneca

  • Nightly prices starting at

    Seneca holiday rentals start at €43 per night before taxes and fees

  • Verified guest reviews

    Over 1,880 verified reviews to help you choose

  • Family-friendly holiday rentals

    30 properties offer extra space & child-friendly amenities

  • Pet-friendly holiday rentals

    Find 10 rentals that welcome pets

  • Rentals with dedicated workspaces

    10 properties have a dedicated workspace

  • Wifi availability

    40 of Seneca holiday rentals include wifi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi and Pool across Seneca rentals

  • 4.9 Average rating

    Seneca stays are highly rated by guests – averaging 4.9 out of 5!

Top-rated house rentals in Seneca

Guests agree: these houses are highly rated for location, cleanliness and more.

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Superhost
A serene view of the cove showcases calm blue waters bordered by lush greenery and trees. Several boats are docked at a wooden pier, with homes visible along the shoreline. Fluffy clouds drift in a clear blue sky above this tranquil scene.
Home in Seneca
4.85 out of 5 average rating, 89 reviews

Peaceful Lake Keowee Waterfront Home ~Near Clemson

Live out your lake dreams at this 3/3 conveniently located 5 minutes to downtown Seneca!! Swim in the beautiful Keowee water right off private dock with direct access from backyard. Bring your boat or explore Lake Keowee in 2 available kayaks. Enjoy outdoor dining on the deck overlooking the lake, cooking in the open kitchen, grilling out in the backyard, or enjoying the fire pit. Separate downstairs suite with private access. Only 7 miles from Clemson and down the street from the Keowee Marina

Top guest favourite
Home in Seneca
4.95 out of 5 average rating, 146 reviews

Hanover Haven 3 BR/2 Bath

Hanover Haven is located close to all you need! Clemson University is only 3 miles away. There are 3 full grocery stores within 5 minutes. Lake Keowee access and marina all within 5 miles. The Gathering space is such a great place to have family fun! There are card games and large TVs with multiple streaming platforms. We are also working on a great outdoor space that will include a grill and sail shade ready for the summer. There is also an RV on the property that is an AirBNB with privacy.

Top guest favourite
A landscaped outdoor area features a winding pathway surrounded by mulch and greenery. Comfortable seating is arranged under the shade of trees, providing views of the lake. The water is visible beyond the trees, with structures in the background suggesting recreational activities.
Home in West Union
4.93 out of 5 average rating, 166 reviews

Dujardins Keowee Waterfront Home

2 night min. Deep water lot on Lake Keowee with double dock, and tons of entertaining space. On the main level, the great room/dining room is open to the kitchen. 4 bedrooms total, 3 king bedrooms (2 on first floor), 1 king and a bunk room with 2 doubles and 2 singles. A canoe, 2 paddle boards and 2 double kayaks included. Shuffleboard, foosball, outdoor Ping-Pong, board games and two person pac-man game, with additional 60 games! towels and linens included! Pickleball/tennis 10 min away!

Top guest favourite
The exterior of a renovated farmhouse is showcased, featuring a gravel driveway and a spacious front porch. The structure exhibits a light-colored façade with multiple large windows, surrounded by trees and open space in a quiet residential setting.
Home in Clemson
4.97 out of 5 average rating, 112 reviews

5 BR/5BA house in the heart of Clemson

Completely updated and remodeled one of a kind farmhouse on .97 acres, minutes from the Clemson campus. Perfect getaway for families or groups in town for Clemson events or time on the lake. Large, eat in kitchen on main level with two living areas. 2 BR/3 BA on main level, 3BR/2BA on second level. Home is pet friendly with a maximum of 2 pets for an additional $50 per stay in addition to the $150 cleaning fee. No parties or excessive noise as the home sits in a quiet residential area.

Guest favourite
A comfortable living room is presented with two sofas, a wooden coffee table, and a rustic stone fireplace. A television rests on a wooden media console, while natural light enters through nearby windows. The flooring is finished in a warm tone, creating an inviting space.
Home in Seneca
4.95 out of 5 average rating, 208 reviews

Private lake setting close to Clemson University

House is located in a private community yet only 2.5 miles to Death Valley and Clemson. Enjoy a walk down to the lake or relax on the back deck. WIFI is included with access to Hulu and Disney+. Kid friendly as well. Property is also within 1.2 miles of Oconee Airport, 0.7 miles to a dock, 1.5 miles to the grocery store, and less than 1.3 miles to Y beach public parking (avoid game day traffic if you are coming in for football). Close to everything in Oconee, Pickens and Anderson Counties.

Guest favourite
Home in Six Mile
4.84 out of 5 average rating, 281 reviews

House on Lake Keowee swim beach in cove w/ Dock

This two story home is located at the end of a very quiet cove with plenty of water. The beach has a fresh 6 inches of sand installed for the lake season. The walk to the lake is very short on an almost flat surface. The home will accommodate a family up to six people. The house has two floors. The main floor has a large living room with plenty of comfortable seating and satellite TV service provided. The entire main floor has hard woods along with the Master Bed Room and bed room #2.

Top guest favourite
An aerial view of a spacious two-level brick home is presented, showcasing a large parking area in front with two garage doors visible. Surrounding greenery enhances the setting, while the property is bordered by trees, providing a sense of privacy.
Home in Anderson
4.95 out of 5 average rating, 148 reviews

Clemson Lake Hartwell Waterfront, Pontoon Rental

Come and enjoy a relaxing family vacation on beautiful Lake Hartwell in this spacious 2 level home. Plenty of room for multiple families to share. This 7600 sq. ft lakefront home sleep up to 18 featuring 7 bedrooms with 1 additional rooms with sofa beds; 5 full-sized bathrooms; 1 laundry area with 2 washers & 2 dryers. Each level boasts a fully furnished kitchen along with a large entertainment area. Breakfast area off main kitchen in addition to a spacious dining room that seats up to 10.

Guest favourite
Home in Westminster
4.94 out of 5 average rating, 302 reviews

Waterfall Views, Lake Hartwell, Highland Architect

Come and enjoy nature with 100+ acres to roam. Architect James Fox designed this cantilevered cliffside home overlooking a beautiful waterfall. Feel like you are in the trees, in an area much as it was when inhabited by Cherokee Indians. Stream feeds into Lake Hartwell. In the summer months on the weekends and holidays kayaks, jet skis and small boats visit the falls. This property is in the foothills of the Appalachian Mountains. Please respect our pet policy, only service animals.

Guest favourite
A bright living area is equipped with a ceiling fan and offers a comfortable seating arrangement on a spacious sofa and chairs. A coffee table is centered on a decorative rug, while a dining area is visible in the background. Large windows allow natural light to fill the space.
Home in Seneca
4.98 out of 5 average rating, 102 reviews

Singing Pines Cottage

Right among the pines of South Carolina you will find our cottage. It's 5 minutes from the Historic Ram Cat Alley with Live Outdoor music every Thursday Night (Apr.-Oct.), Shopping, Boutiques, Restaurants, Breweries, and Coffee Shops. It's only 12 minutes from Clemson University, and a short drive to Lake Keowee, Lake Jocassee, and Lake Hartwell. This area is home to numerous Waterfalls, Hiking Trails, and good southern barbecue. We do not host work crews.

Top guest favourite
A charming cottage is surrounded by lush greenery and tall trees, featuring a welcoming front porch with seating. The exterior is clad in grey siding and highlights stylish architectural design elements. A gravel driveway leads up to the house, emphasizing its peaceful and private setting.
Home in Seneca
5.0 out of 5 average rating, 141 reviews

The Cottage

Relax, recharge, and enjoy the quiet. Unwind on the front porch as the sun sets and nature comes alive with the peaceful sounds of evening. Spend time by the pond and cast a line for a simple, relaxing escape (fishing poles not provided). Private and serene, yet just 5 minutes to Walmart and Oconee Memorial Hospital—and only 13 miles to Clemson. The perfect blend of tranquility and convenience. Minimum age to book is 25 years of age.

Top guest favourite
The charming house, surrounded by lush greenery, features a screened-in front porch that invites relaxation. A flag gently flutters on the porch, while well-maintained landscaping frames the entrance. Large trees provide ample shade, enhancing the tranquil outdoor environment.
Home in Westminster
4.94 out of 5 average rating, 139 reviews

Shady Rest

As you enter the screened in front porch you will instantly relax, experience a peaceful and quiet tree lined front yard. The house has plenty of shade and old oaks, built in 1935 has the charm of visiting great grandmother’s farm house without the wallpaper. Large side deck with grill, hot tub and plenty of shaded sitting. Side yard has a fire pit for evening campfires and roasting marshmallows. The house has an open floor plan.

Top guest favourite
A single-story house with a welcoming porch is surrounded by a manicured lawn. Lush green shrubs and flower beds frame the entrance, complemented by an American flag displayed on the front. The carport is visible to one side, providing additional parking.
Home in Seneca
4.95 out of 5 average rating, 144 reviews

Getaway on Lake Hartwell: Pontoon Rental, Clemson

Our 3 bedroom house is located on Lake Hartwell and is just a 15 min drive to Clemson University. You can enjoy access to the dock and beach which are a quick golf cart ride away. We have paddle boards on the dock and kayaks, coolers, bagged ice, fishing poles etc upon request. Off the back of the detached garage there’s a furnished screened-in deck with a grill that overlooks the end of the cove and fire pit below.

Popular amenities for house rentals in Seneca

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Avg. price€147€173€164€168€219€305€141€203€188€168€201€156
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