
House holiday rentals in Seneca
Find and book unique houses on Airbnb
Quick stats about house rentals in Seneca

Total holiday rentals
Explore 40 holiday rentals in Seneca

Nightly prices starting at
Seneca holiday rentals start at €44 per night before taxes and fees

Verified guest reviews
Over 1,880 verified reviews to help you choose

Family-friendly holiday rentals
30 properties offer extra space & child-friendly amenities

Pet-friendly holiday rentals
Find 10 rentals that welcome pets

Rentals with dedicated workspaces
10 properties have a dedicated workspace

Wifi availability
40 of Seneca holiday rentals include wifi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across Seneca rentals

4.9 Average rating
Seneca stays are highly rated by guests – averaging 4.9 out of 5!
Top-rated house rentals in Seneca
Guests agree: these houses are highly rated for location, cleanliness and more.

Peaceful Lake Keowee Waterfront Home ~Near Clemson
Live out your lake dreams at this 3/3 conveniently located 5 minutes to downtown Seneca!! Swim in the beautiful Keowee water right off private dock with direct access from backyard. Bring your boat or explore Lake Keowee in 2 available kayaks. Enjoy outdoor dining on the deck overlooking the lake, cooking in the open kitchen, grilling out in the backyard, or enjoying the fire pit. Separate downstairs suite with private access. Only 7 miles from Clemson and down the street from the Keowee Marina
4.86 out of 5 average rating, 90 reviews
Hanover Haven 3 BR/2 Bath
Hanover Haven is located close to all you need! Clemson University is only 3 miles away. There are 3 full grocery stores within 5 minutes. Lake Keowee access and marina all within 5 miles. The Gathering space is such a great place to have family fun! There are card games and large TVs with multiple streaming platforms. We are also working on a great outdoor space that will include a grill and sail shade ready for the summer. There is also an RV on the property that is an AirBNB with privacy.
4.95 out of 5 average rating, 146 reviews
Dujardins Keowee Waterfront Home
2 night min. Deep water lot on Lake Keowee with double dock, and tons of entertaining space. On the main level, the great room/dining room is open to the kitchen. 4 bedrooms total, 3 king bedrooms (2 on first floor), 1 king and a bunk room with 2 doubles and 2 singles. A canoe, 2 paddle boards and 2 double kayaks included. Shuffleboard, foosball, outdoor Ping-Pong, board games and two person pac-man game, with additional 60 games! towels and linens included! Pickleball/tennis 10 min away!
4.93 out of 5 average rating, 166 reviews
Private lake setting close to Clemson University
House is located in a private community yet only 2.5 miles to Death Valley and Clemson. Enjoy a walk down to the lake or relax on the back deck. WIFI is included with access to Hulu and Disney+. Kid friendly as well. Property is also within 1.2 miles of Oconee Airport, 0.7 miles to a dock, 1.5 miles to the grocery store, and less than 1.3 miles to Y beach public parking (avoid game day traffic if you are coming in for football). Close to everything in Oconee, Pickens and Anderson Counties.
4.95 out of 5 average rating, 208 reviews
House on Lake Keowee swim beach in cove w/ Dock
This two story home is located at the end of a very quiet cove with plenty of water. The beach has a fresh 6 inches of sand installed for the lake season. The walk to the lake is very short on an almost flat surface. The home will accommodate a family up to six people. The house has two floors. The main floor has a large living room with plenty of comfortable seating and satellite TV service provided. The entire main floor has hard woods along with the Master Bed Room and bed room #2.
4.84 out of 5 average rating, 283 reviews
Waterfall Views, Lake Hartwell, Highland Architect
Come and enjoy nature with 100+ acres to roam. Architect James Fox designed this cantilevered cliffside home overlooking a beautiful waterfall. Feel like you are in the trees, in an area much as it was when inhabited by Cherokee Indians. Stream feeds into Lake Hartwell. In the summer months on the weekends and holidays kayaks, jet skis and small boats visit the falls. This property is in the foothills of the Appalachian Mountains. Please respect our pet policy, only service animals.
4.94 out of 5 average rating, 302 reviews
Singing Pines Cottage
Right among the pines of South Carolina you will find our cottage. It's 5 minutes from the Historic Ram Cat Alley with Live Outdoor music every Thursday Night (Apr.-Oct.), Shopping, Boutiques, Restaurants, Breweries, and Coffee Shops. It's only 12 minutes from Clemson University, and a short drive to Lake Keowee, Lake Jocassee, and Lake Hartwell. This area is home to numerous Waterfalls, Hiking Trails, and good southern barbecue. We do not host work crews.
4.98 out of 5 average rating, 102 reviews
The Cottage
Relax, recharge, and enjoy the quiet. Unwind on the front porch as the sun sets and nature comes alive with the peaceful sounds of evening. Spend time by the pond and cast a line for a simple, relaxing escape (fishing poles not provided). Private and serene, yet just 5 minutes to Walmart and Oconee Memorial Hospital—and only 13 miles to Clemson. The perfect blend of tranquility and convenience. Minimum age to book is 25 years of age.
5.0 out of 5 average rating, 143 reviews
Shady Rest
As you enter the screened in front porch you will instantly relax, experience a peaceful and quiet tree lined front yard. The house has plenty of shade and old oaks, built in 1935 has the charm of visiting great grandmother’s farm house without the wallpaper. Large side deck with grill, hot tub and plenty of shaded sitting. Side yard has a fire pit for evening campfires and roasting marshmallows. The house has an open floor plan.
4.94 out of 5 average rating, 139 reviews
Getaway on Lake Hartwell: Pontoon Rental, Clemson
Our 3 bedroom house is located on Lake Hartwell and is just a 15 min drive to Clemson University. You can enjoy access to the dock and beach which are a quick golf cart ride away. We have paddle boards on the dock and kayaks, coolers, bagged ice, fishing poles etc upon request. Off the back of the detached garage there’s a furnished screened-in deck with a grill that overlooks the end of the cove and fire pit below.
4.95 out of 5 average rating, 144 reviews
5 Min to Clemson | Large Driveway & Self Check-In
Welcome to your Cozy Family Home! Escape to this charming 3-bedroom, 2-bathroom home, just a short 3-mile drive from the iconic Clemson Memorial Stadium. Whether you're planning a trip to the lake, tailgating for the big game, catching up with friends, or exploring the local hiking trails, this quiet and convenient home is your ideal base. Can't wait for you to enjoy Clemson, SC. Go Tigers! Pet Fee of $100.
4.96 out of 5 average rating, 150 reviews
Perfect Lake Hartwell Getaway! Gorgeous Views!
Lake living at its best: Amazing views, deep water with a perfect location steps from the shoreline and for you Tiger fans this property is ten minutes from Clemson. Waterfront point lots that are this close to the water are extremely rare. This house is only a very short ride from Clemson Marina and the Walker Course. Gorgeous Sunsets from the dock!
4.96 out of 5 average rating, 107 reviewsPopular amenities for house rentals in Seneca
House rentals with a pool

Keowee Key Luxury Condo - Stunning Views!
4.98 out of 5 average rating, 169 reviews
Lake house w/ a pool and Pickleball court
4.82 out of 5 average rating, 131 reviews
Pet-Friendly Retreat • Hot Tub • Fenced Yard
4.99 out of 5 average rating, 166 reviews
Clemson- 5 Min | Pool | Hot Tub | Epic Game Lounge
4.96 out of 5 average rating, 26 reviews
Cottage close to Clemson with private pool!
4.96 out of 5 average rating, 23 reviews
See you soon Keowee Kustom!*NO Dock!
5.0 out of 5 average rating, 20 reviews
Clemson Games + ON Lake Hartwell
4.86 out of 5 average rating, 21 reviews
* Keowee Key* Lake* Fireplace*Golf*Tennis*Gym*
4.78 out of 5 average rating, 40 reviewsWeekly house rentals

Lakefront Mid-Century Dream Home / 3 mi to Clemson
4.94 out of 5 average rating, 78 reviews
The Carriage House at South Townville
5.0 out of 5 average rating, 20 reviews
Johnsons Cove/Lakefront Retreat/Hot Tub/EV Charger
4.98 out of 5 average rating, 64 reviews
Cozy Modern Home Close Clemson
4.98 out of 5 average rating, 50 reviews
Lakefront+Near Clemson+Dock+Kayaks+Putting Green
4.98 out of 5 average rating, 56 reviews
Sweet Tea Retreats
4.94 out of 5 average rating, 17 reviews
The Landing Spot
4.89 out of 5 average rating, 47 reviews
Near Clemson, Hot Tub, Game Room, Kayaks, Dock
4.9 out of 5 average rating, 42 reviewsPrivate house rentals

25 minutes from Clemson, newly remodeled home!
5.0 out of 5 average rating, 40 reviews
Lakefront Oasis on Lake Keowee
5.0 out of 5 average rating, 32 reviews
Lakefront Football Paradise in Seneca SC
4.94 out of 5 average rating, 16 reviews
Keowee Lakefront Home | Hot Tub, Kayaks, Dock!
4.91 out of 5 average rating, 68 reviews
Fire pits, Kayaks, Bocce Court, Fenced in Dog Run
5.0 out of 5 average rating, 25 reviews
Tee House... waterfront on beautiful Lake Keowee
4.97 out of 5 average rating, 75 reviews
Entire home with 3 docks on Hartwell near Clemson
4.8 out of 5 average rating, 25 reviews
No cleaning fee farmhouse lake keowee near Clemson
4.93 out of 5 average rating, 60 reviewsWhen is the best time to visit Seneca?
| Month | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sept | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Avg. price | €148 | €174 | €165 | €169 | €220 | €307 | €142 | €205 | €189 | €169 | €202 | €157 |
| Avg. temp | 6°C | 8°C | 12°C | 16°C | 21°C | 25°C | 27°C | 26°C | 23°C | 17°C | 11°C | 7°C |
Destinations to explore
- Nashville Holiday rentals
- Atlanta Holiday rentals
- Myrtle Beach Holiday rentals
- Charlotte Holiday rentals
- Gatlinburg Holiday rentals
- Savannah Holiday rentals
- Pigeon Forge Holiday rentals
- Charleston Holiday rentals
- Hilton Head Island Holiday rentals
- North Myrtle Beach Holiday rentals
- Louisville Holiday rentals
- Asheville Holiday rentals
- Clemson University
- Table Rock State Park
- Helen Tubing & Waterpark
- Black Rock Mountain State Park
- Gorges State Park
- Tallulah Gorge State Park
- Devils Fork State Park
- Bell Mountain
- DuPont State Forest
- Unicoi State Park and Lodge
- Chattooga Belle Farm
- Bon Secours Wellness Arena
- Jump Off Rock
- Fred W Symmes Chapel
- Falls Park On The Reedy
- Jones Gap State Park
- Fluor Field at the West End
- Peace Center
- Whitewater Falls
- Anna Ruby Falls
- Carl Sandburg Home National Historic Site
- Dry Falls
- Soquee River
- Smithgall Woods State Park





