House holiday rentals in Seneca

Find and book unique houses on Airbnb

Quick stats about house rentals in Seneca

Total holiday rentals
Explore 40 holiday rentals in Seneca
Nightly prices starting at
Seneca holiday rentals start at €44 per night before taxes and fees
Verified guest reviews
Over 1,880 verified reviews to help you choose
Family-friendly holiday rentals
30 properties offer extra space & child-friendly amenities
Pet-friendly holiday rentals
Find 10 rentals that welcome pets
Rentals with dedicated workspaces
10 properties have a dedicated workspace
Wifi availability
40 of Seneca holiday rentals include wifi access
Popular amenities for guests
Guests love Kitchen, Wifi and Pool across Seneca rentals
4.9 Average rating
Seneca stays are highly rated by guests – averaging 4.9 out of 5!

Top-rated house rentals in Seneca

Guests agree: these houses are highly rated for location, cleanliness and more.

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Superhost

A serene view of the cove showcases calm blue waters bordered by lush greenery and trees. Several boats are docked at a wooden pier, with homes visible along the shoreline. Fluffy clouds drift in a clear blue sky above this tranquil scene.

Home in Seneca

Peaceful Lake Keowee Waterfront Home ~Near Clemson

Live out your lake dreams at this 3/3 conveniently located 5 minutes to downtown Seneca!! Swim in the beautiful Keowee water right off private dock with direct access from backyard. Bring your boat or explore Lake Keowee in 2 available kayaks. Enjoy outdoor dining on the deck overlooking the lake, cooking in the open kitchen, grilling out in the backyard, or enjoying the fire pit. Separate downstairs suite with private access. Only 7 miles from Clemson and down the street from the Keowee Marina

ValueLocationCondition

4.86 out of 5 average rating, 90 reviews

Top guest favourite

Home in Seneca

Hanover Haven 3 BR/2 Bath

Hanover Haven is located close to all you need! Clemson University is only 3 miles away. There are 3 full grocery stores within 5 minutes. Lake Keowee access and marina all within 5 miles. The Gathering space is such a great place to have family fun! There are card games and large TVs with multiple streaming platforms. We are also working on a great outdoor space that will include a grill and sail shade ready for the summer. There is also an RV on the property that is an AirBNB with privacy.

ValueFamilyView

4.95 out of 5 average rating, 146 reviews

Guest favourite

A comfortable living room is presented with two sofas, a wooden coffee table, and a rustic stone fireplace. A television rests on a wooden media console, while natural light enters through nearby windows. The flooring is finished in a warm tone, creating an inviting space.

Home in Seneca

Private lake setting close to Clemson University

House is located in a private community yet only 2.5 miles to Death Valley and Clemson. Enjoy a walk down to the lake or relax on the back deck. WIFI is included with access to Hulu and Disney+. Kid friendly as well. Property is also within 1.2 miles of Oconee Airport, 0.7 miles to a dock, 1.5 miles to the grocery store, and less than 1.3 miles to Y beach public parking (avoid game day traffic if you are coming in for football). Close to everything in Oconee, Pickens and Anderson Counties.

LocationValueQuiet

4.95 out of 5 average rating, 208 reviews

Guest favourite

Home in Westminster

Waterfall Views, Lake Hartwell, Highland Architect

Come and enjoy nature with 100+ acres to roam. Architect James Fox designed this cantilevered cliffside home overlooking a beautiful waterfall. Feel like you are in the trees, in an area much as it was when inhabited by Cherokee Indians. Stream feeds into Lake Hartwell. In the summer months on the weekends and holidays kayaks, jet skis and small boats visit the falls. This property is in the foothills of the Appalachian Mountains. Please respect our pet policy, only service animals.

ValueFamilyLong stay

4.94 out of 5 average rating, 302 reviews

Guest favourite

A spacious sunken living area features a large brick fireplace as a central focal point, flanked by two inviting seating arrangements. Natural wood beams extend across the ceiling, and light fills the space through multiple large windows, creating a warm and welcoming environment.

Home in Seneca

Lakefront Mid-Century Dream Home / 3 mi to Clemson

We excitedly invite you to come enjoy a one of a kind experience at our personal lakefront home. Originally designed and built in the 60s, this home now has all the modern necessities, yet still brims with endless midcentury charm. Located only 3 miles from Clemson, our large outdoor entertainment space and direct access to our private dock invite you to enjoy the many sights and sounds that the lake has to offer. Use our 2 kayaks and canoe, or use the dock to tie up your own boat!

ValueFamilyDecor

4.94 out of 5 average rating, 78 reviews

Guest favourite

A bright living area is equipped with a ceiling fan and offers a comfortable seating arrangement on a spacious sofa and chairs. A coffee table is centered on a decorative rug, while a dining area is visible in the background. Large windows allow natural light to fill the space.

Home in Seneca

Singing Pines Cottage

Right among the pines of South Carolina you will find our cottage. It's 5 minutes from the Historic Ram Cat Alley with Live Outdoor music every Thursday Night (Apr.-Oct.), Shopping, Boutiques, Restaurants, Breweries, and Coffee Shops. It's only 12 minutes from Clemson University, and a short drive to Lake Keowee, Lake Jocassee, and Lake Hartwell. This area is home to numerous Waterfalls, Hiking Trails, and good southern barbecue. We do not host work crews.

ValueLocationQuiet

4.98 out of 5 average rating, 102 reviews

Top guest favourite

A charming cottage is surrounded by lush greenery and tall trees, featuring a welcoming front porch with seating. The exterior is clad in grey siding and highlights stylish architectural design elements. A gravel driveway leads up to the house, emphasizing its peaceful and private setting.

Home in Seneca

The Cottage

Relax, recharge, and enjoy the quiet. Unwind on the front porch as the sun sets and nature comes alive with the peaceful sounds of evening. Spend time by the pond and cast a line for a simple, relaxing escape (fishing poles not provided). Private and serene, yet just 5 minutes to Walmart and Oconee Memorial Hospital—and only 13 miles to Clemson. The perfect blend of tranquility and convenience. Minimum age to book is 25 years of age.

ValueLocationCheckout

5.0 out of 5 average rating, 144 reviews

Top guest favourite

The charming house, surrounded by lush greenery, features a screened-in front porch that invites relaxation. A flag gently flutters on the porch, while well-maintained landscaping frames the entrance. Large trees provide ample shade, enhancing the tranquil outdoor environment.

Home in Westminster

Shady Rest

As you enter the screened in front porch you will instantly relax, experience a peaceful and quiet tree lined front yard. The house has plenty of shade and old oaks, built in 1935 has the charm of visiting great grandmother’s farm house without the wallpaper. Large side deck with grill, hot tub and plenty of shaded sitting. Side yard has a fire pit for evening campfires and roasting marshmallows. The house has an open floor plan.

LocationValueBack garden

4.94 out of 5 average rating, 139 reviews

Guest favourite

A single-story house with a welcoming porch is surrounded by a manicured lawn. Lush green shrubs and flower beds frame the entrance, complemented by an American flag displayed on the front. The carport is visible to one side, providing additional parking.

Home in Seneca

Getaway on Lake Hartwell: Pontoon Rental, Clemson

Our 3 bedroom house is located on Lake Hartwell and is just a 15 min drive to Clemson University. You can enjoy access to the dock and beach which are a quick golf cart ride away. We have paddle boards on the dock and kayaks, coolers, bagged ice, fishing poles etc upon request. Off the back of the detached garage there’s a furnished screened-in deck with a grill that overlooks the end of the cove and fire pit below.

LocationFamilyCondition

4.94 out of 5 average rating, 146 reviews

Top guest favourite

Home in Seneca

The Carriage House at South Townville

Stay in a charming loft-style carriage house in historic downtown Seneca. This two-bedroom space comfortably sleeps 4 and features a full kitchen, private bathroom, and convenient washer/dryer combo. Enjoy walkable access to local shops, restaurants, and coffee spots, or take a short drive to Lake Keowee for boating and views, or visit Clemson University for games and campus events. Perfect for a relaxing getaway.

FamilyLocationHospitality

5.0 out of 5 average rating, 21 reviews

Guest favourite

A bright and spacious kitchen features a central island with a granite countertop, surrounded by blue upholstered chairs. A dining table with wicker chairs is located nearby, and natural light fills the room through sliding glass doors leading to the outdoor area.

Home in Seneca

5 Min to Clemson | Large Driveway & Self Check-In

Welcome to your Cozy Family Home! Escape to this charming 3-bedroom, 2-bathroom home, just a short 3-mile drive from the iconic Clemson Memorial Stadium. Whether you're planning a trip to the lake, tailgating for the big game, catching up with friends, or exploring the local hiking trails, this quiet and convenient home is your ideal base. Can't wait for you to enjoy Clemson, SC. Go Tigers! Pet Fee of $100.

LocationValueLong stay

4.96 out of 5 average rating, 151 reviews

Top guest favourite

The exterior of a spacious single-story home features a red metal roof and light-colored siding. A welcoming blue front door is positioned under a small porch, surrounded by green shrubs. A gravel driveway leads up to the house, framed by trees and a clear blue sky.

Home in Central

The House on Oak Grove

Enjoy your time spent in this spacious and peaceful pet friendly space. Nicely appointed with everything you need for a short or long term stay. Ten easy miles to Clemson and 3 miles to SWU. Besides the open living space the house has a screened porch and accomodates 4 with 2 bedroom & 2 adjoining baths. The home includes washer & dryer, coffee bar, granite countertops, and microwave.

LocationFamilyHeating

4.96 out of 5 average rating, 168 reviews