
House holiday rentals in Seneca
Find and book unique houses on Airbnb
Quick stats about house rentals in Seneca

Total holiday rentals
Explore 40 holiday rentals in Seneca

Nightly prices starting at
Seneca holiday rentals start at €43 per night before taxes and fees

Verified guest reviews
Over 1,880 verified reviews to help you choose

Family-friendly holiday rentals
30 properties offer extra space & child-friendly amenities

Pet-friendly holiday rentals
Find 10 rentals that welcome pets

Rentals with dedicated workspaces
10 properties have a dedicated workspace

Wifi availability
40 of Seneca holiday rentals include wifi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across Seneca rentals

4.9 Average rating
Seneca stays are highly rated by guests – averaging 4.9 out of 5!
Top-rated house rentals in Seneca
Guests agree: these houses are highly rated for location, cleanliness and more.

Lake Hartwell house w/ dock 2 miles from Clemson.
This is a simple, comfortable, recently renovated (2019) home for Clemson fans and lake vacationers. Decor is vintage/antique. It is 3 1/2 miles to stadium entrance. We have a deep water cove with fire ring, decks, dock, and stairs to gangway, parking for 6 cars, woods and lake on 3 sides, a variety of restaurants nearby. Clemson Marina is 1 cove away. Clemson golf course is across the lake. We are PET FRIENDLY with a max of 2 dogs. There is a $75 pet fee. Read the house rules concerning pets.
4.96 out of 5 average rating, 167 reviews
Hanover Haven 3 BR/2 Bath
Hanover Haven is located close to all you need! Clemson University is only 3 miles away. There are 3 full grocery stores within 5 minutes. Lake Keowee access and marina all within 5 miles. The Gathering space is such a great place to have family fun! There are card games and large TVs with multiple streaming platforms. We are also working on a great outdoor space that will include a grill and sail shade ready for the summer. There is also an RV on the property that is an AirBNB with privacy.
4.95 out of 5 average rating, 143 reviews
Private lake setting close to Clemson University
House is located in a private community yet only 2.5 miles to Death Valley and Clemson. Enjoy a walk down to the lake or relax on the back deck. WIFI is included with access to Hulu and Disney+. Kid friendly as well. Property is also within 1.2 miles of Oconee Airport, 0.7 miles to a dock, 1.5 miles to the grocery store, and less than 1.3 miles to Y beach public parking (avoid game day traffic if you are coming in for football). Close to everything in Oconee, Pickens and Anderson Counties.
4.95 out of 5 average rating, 208 reviews
House on Lake Keowee swim beach in cove w/ Dock
This two story home is located at the end of a very quiet cove with plenty of water. The beach has a fresh 6 inches of sand installed for the lake season. The walk to the lake is very short on an almost flat surface. The home will accommodate a family up to six people. The house has two floors. The main floor has a large living room with plenty of comfortable seating and satellite TV service provided. The entire main floor has hard woods along with the Master Bed Room and bed room #2.
4.84 out of 5 average rating, 281 reviews
Clemson Lake Hartwell Waterfront, Pontoon Rental
Come and enjoy a relaxing family vacation on beautiful Lake Hartwell in this spacious 2 level home. Plenty of room for multiple families to share. This 7600 sq. ft lakefront home sleep up to 18 featuring 7 bedrooms with 1 additional rooms with sofa beds; 5 full-sized bathrooms; 1 laundry area with 2 washers & 2 dryers. Each level boasts a fully furnished kitchen along with a large entertainment area. Breakfast area off main kitchen in addition to a spacious dining room that seats up to 10.
4.94 out of 5 average rating, 145 reviews
The Cozy Cottage
Beautiful, well-maintained home located in a private subdivision just minutes away from shopping, restaurants, lakes, golf courses, and Clemson University. This home has a fully equipped kitchen for dining in and a back patio for grilling out. The backyard overlooks a peaceful wooded area, providing a serene and private escape. Our home offers the perfect blend of tranquility and convenience. Perfect for getaways, football weekends, graduation, and other Clemson University events!
4.99 out of 5 average rating, 235 reviews
Singing Pines Cottage
Right among the pines of South Carolina you will find our cottage. It's 5 minutes from the Historic Ram Cat Alley with Live Outdoor music every Thursday Night (Apr.-Oct.), Shopping, Boutiques, Restaurants, Breweries, and Coffee Shops. It's only 12 minutes from Clemson University, and a short drive to Lake Keowee, Lake Jocassee, and Lake Hartwell. This area is home to numerous Waterfalls, Hiking Trails, and good southern barbecue. We do not host work crews.
4.98 out of 5 average rating, 102 reviews
The Cottage
Relax, recharge, and enjoy the quiet. Unwind on the front porch as the sun sets and nature comes alive with the peaceful sounds of evening. Spend time by the pond and cast a line for a simple, relaxing escape (fishing poles not provided). Private and serene, yet just 5 minutes to Walmart and Oconee Memorial Hospital—and only 13 miles to Clemson. The perfect blend of tranquility and convenience. Minimum age to book is 25 years of age.
5.0 out of 5 average rating, 140 reviews
Hidden Lake Sanctuary
Recently remodeled with over 3,000 sq ft of comfortable living space, this peaceful retreat is tucked away in a quiet cove. Enjoy a large, fully stocked kitchen, spacious private deck, and relaxing hot tub. The property includes 2 kayaks and 2 paddleboards for exploring the cove. The path to the private dock is steep and best suited for active guests. Bringing a boat? A nearby public launch makes it easy to get out on the lake.
4.93 out of 5 average rating, 144 reviews
Shady Rest
As you enter the screened in front porch you will instantly relax, experience a peaceful and quiet tree lined front yard. The house has plenty of shade and old oaks, built in 1935 has the charm of visiting great grandmother’s farm house without the wallpaper. Large side deck with grill, hot tub and plenty of shaded sitting. Side yard has a fire pit for evening campfires and roasting marshmallows. The house has an open floor plan.
4.93 out of 5 average rating, 138 reviews
Getaway on Lake Hartwell: Pontoon Rental, Clemson
Our 3 bedroom house is located on Lake Hartwell and is just a 15 min drive to Clemson University. You can enjoy access to the dock and beach which are a quick golf cart ride away. We have paddle boards on the dock and kayaks, coolers, bagged ice, fishing poles etc upon request. Off the back of the detached garage there’s a furnished screened-in deck with a grill that overlooks the end of the cove and fire pit below.
4.95 out of 5 average rating, 144 reviews
5 Min to Clemson | Large Driveway & Self Check-In
Welcome to your Cozy Family Home! Escape to this charming 3-bedroom, 2-bathroom home, just a short 3-mile drive from the iconic Clemson Memorial Stadium. Whether you're planning a trip to the lake, tailgating for the big game, catching up with friends, or exploring the local hiking trails, this quiet and convenient home is your ideal base. Can't wait for you to enjoy Clemson, SC. Go Tigers! Pet Fee of $100.
4.96 out of 5 average rating, 149 reviewsPopular amenities for house rentals in Seneca
House rentals with a pool

Pet-Friendly Retreat • Hot Tub • Fenced Yard
4.99 out of 5 average rating, 162 reviews
Keowee Key Luxury Condo - Stunning Views!
4.98 out of 5 average rating, 168 reviews
Lake house w/ a pool and Pickleball court
4.82 out of 5 average rating, 130 reviews
Overlook Vacation House with Pool!
4.98 out of 5 average rating, 41 reviews
Clemson- 5 Min | Pool | Hot Tub | Epic Game Lounge
4.96 out of 5 average rating, 25 reviews
See you soon Keowee Kustom!*NO Dock!
5.0 out of 5 average rating, 20 reviews
* Keowee Key* Lake* Fireplace*Golf*Tennis*Gym*
4.78 out of 5 average rating, 40 reviews
Lazy Dayz - on Lake Keowee w/dock, pool & hot tub
4.92 out of 5 average rating, 59 reviewsWeekly house rentals

Dujardins Keowee Waterfront Home
4.93 out of 5 average rating, 166 reviews
Peaceful Lake Keowee Waterfront Home ~Near Clemson
4.85 out of 5 average rating, 88 reviews
Lakefront Mid-Century Dream Home / 3 mi to Clemson
4.94 out of 5 average rating, 78 reviews
The Carriage House at South Townville
5.0 out of 5 average rating, 17 reviews
Johnsons Cove - Lakefront Retreat With EV Charger
4.98 out of 5 average rating, 63 reviews
Sweet Tea Retreats
4.94 out of 5 average rating, 17 reviews
Lakefront Home w/Deep Water Dock 20 min to Clemson
4.97 out of 5 average rating, 31 reviews
Modern Home Near Keowee, Clemson, Walhalla
4.97 out of 5 average rating, 35 reviewsPrivate house rentals

Lakefront Getaway~Dock~Fire Pit~Kayak & Games!
4.96 out of 5 average rating, 25 reviews
Mountain Road Cottage
4.99 out of 5 average rating, 67 reviews
Entire home with 3 docks on Hartwell near Clemson
4.8 out of 5 average rating, 25 reviews
No cleaning fee farmhouse lake keowee near Clemson
4.93 out of 5 average rating, 59 reviews
Lakefront Oasis on Lake Keowee
5.0 out of 5 average rating, 31 reviews
Lakefront Football Paradise in Seneca SC
4.93 out of 5 average rating, 15 reviews
Point Lot, Boat and PWC Rental
5.0 out of 5 average rating, 31 reviews
Tee House... waterfront on beautiful Lake Keowee
4.97 out of 5 average rating, 74 reviewsWhen is the best time to visit Seneca?
| Month | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sept | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Avg. price | €147 | €173 | €163 | €167 | €218 | €304 | €141 | €203 | €187 | €167 | €200 | €155 |
| Avg. temp | 6°C | 8°C | 12°C | 16°C | 21°C | 25°C | 27°C | 26°C | 23°C | 17°C | 11°C | 7°C |
Destinations to explore
- Nashville Holiday rentals
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- Savannah Holiday rentals
- Pigeon Forge Holiday rentals
- Charleston Holiday rentals
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- North Myrtle Beach Holiday rentals
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- Asheville Holiday rentals
- Clemson University
- Table Rock State Park
- Black Rock Mountain State Park
- Helen Tubing & Waterpark
- Gorges State Park
- Tallulah Gorge State Park
- Devils Fork State Park
- Bell Mountain
- DuPont State Forest
- Unicoi State Park and Lodge
- Chattooga Belle Farm
- Bon Secours Wellness Arena
- Jump Off Rock
- Fred W Symmes Chapel
- Fluor Field at the West End
- Jones Gap State Park
- Falls Park On The Reedy
- Peace Center
- Anna Ruby Falls
- Carl Sandburg Home National Historic Site
- Dry Falls
- Whitewater Falls
- Soquee River
- Smithgall Woods State Park





