Hotel holiday rentals in Panama City

Find and book unique hotel rentals on Airbnb

Top-rated hotel rentals in Panama City

Guests agree: these hotel rentals are highly rated for location, cleanliness and more.

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Superhost

Hotel room in Panamá

4.82 out of 5 average rating, 11 reviews

Very Nice Downtown Panamá Hotel Free Parking

Welcome to the beautiful Aloft Panamá hotel This is a very nice and safe hotel located in the San Francisco area of Panamá with beautiful city views. King or 2 queen based on availability (Feel free to make request prior to booking if you have a preference) All rooms non smoking ($350 fine) No pets allowed Must be 21 with id to checkin Must have credit card for incidentals Checkin time starts at 3pm Checkout time before noon Free Parking Pool Bar/Lounge

Guest favourite

Hotel room in El Cangrejo

4.73 out of 5 average rating, 33 reviews

Hotel room #3 one block from the Metro.

Disfruta de acceso ràpido a los destinos más populares de Ciudad de Panamà, centros comerciales, restaurantes, y áreas turísticas. Cuarto de hotel con baño privado, aire acondicionado, cable TV, recepciòn con 24 horas de servicio y estacionamientos sujetos a disponibilidad. Cerca de restaurantes y casinos. A una cuadra de la estaciòn del Metro que lo lleva en 10 minutos a Albrook Mall, el Centro Comercial más grande de Panamà.

Hotel room in Panamá

4.7 out of 5 average rating, 134 reviews

Panama City Center - Room with private bathroom

We are an accommodation inaugurated in October 2020 located in the center of Panama City. We have several types of rooms, in this case, it is a room with 1 double bed. We offer continuous reception service, high speed WiFi, shared work area, room with vending machine for snacks and coffee and 24 hour security. Our rooms are fully equipped with a private bathroom with hot water, a work desk, air conditioning and cable TV.

Hotel room

4.64 out of 5 average rating, 163 reviews

Hotel Caracas Casco Viejo - 2 Queen Beds Room

✨ Welcome to Hotel Caracas, a charming boutique stay in the heart of Casco Viejo, Panama’s UNESCO-listed gem! 🌆 Located in front of beautiful Plaza Santa Ana, explore the city on foot and enjoy the perfect mix of local life and tourist spots. 🛏️ Each room offers full privacy, a private bathroom 🚿, a peaceful space to relax, and Wi-Fi 📶. 🕒 24/7 front desk, top value 💰 ⭐️ Highly recommended for a unique stay⭐️

Private room in Santa Cruz De Chinina

5 out of 5 average rating, 4 reviews

Comfort and privacy Casa Orquídea

Casa Orquídea es un Hermoso Residencial ubicado en el corazón de la ciudad de Panamá. Bienvenido a la joya de Paitilla rodeada de edificios, mar, y de una hermosa vegetación, esta casa es el secreto mejor guardado en una de las zonas más exclusivas de la ciudad, con espacios seguros para caminar. Este es el paraíso urbano para los amantes de la naturaleza. ¡Desconéctate y relájate en medio de la ciudad!

Guest favourite

Private room in Panamá

4.83 out of 5 average rating, 23 reviews

Desk & Dream Room

Disfruta de la comodidad de este alojamiento tranquilo y céntrico en el corazón de San Francisco, tiene escritorio dentro de la habitación para trabajar o estudiar en un ambiente relax, con las demás comodidades incluyendo televisor led HD de 32" Justo en la calle de al lado está el super mercado, farmacia al frente, restaurantes, tiendas de chinitos, panaderías, paradas del metro bus cercanas.

Superhost

Hotel room in Marbella

4.63 out of 5 average rating, 8 reviews

In the heart of the city.

Hotel Mio Panama we are a 4 star hotel located in Panama City, in the heart of the financial area. Our main goal is to meet any needs of the client, offering the best services to ensure a comfortable and peaceful stay. Among our modern facilities, you will find a pool, spacious and comfortable rooms, gym, meeting rooms, and rooftop. If you like to travel with your pet, we are pet friendly.

Hotel room in Obarrio

5 out of 5 average rating, 3 reviews

Marinn Place | Deluxe King | Cozy Work & Rest

Located in Panama City’s upscale Financial District near Via España and Bella Vista, Marinn Place offers modern comfort, a rooftop pool, and free valet parking in a vibrant urban setting. The spacious Deluxe Double features two plush queen beds, a separate living/sleeping area with a sofa bed, a work desk, and a walk-in glass shower—perfect for families or professionals.

Guest favourite

Hotel room in Panamá

4.86 out of 5 average rating, 44 reviews

Private rooms Sofia's B&B Hostal Boutique

Boutique hostel-style accommodation, we have 7 comfortable private rooms with bathroom, for a total capacity of 18 guests. The rate shown by Airbnb for your reservation is for 2 guests per room, i.e., guests will need to share beds and/or rooms. If you require a special room layout for your group, please contact the host first, as the rate may vary.

Guest favourite

Hotel room in Panamá

4.85 out of 5 average rating, 107 reviews

Corcho rooms #2 - king room with balconies

Enjoy charming “Corcho rooms” in the heart of touristic Casco Viejo district of Panama City. We carefully restored old colonial building and converted it to the restaurant an serviced guest rooms upstairs. “Corcho” is luckily situated in the central, restored part of Casco. Most of the building around are restored and the neighborhood is safe.

Hotel room in Panamá

4.79 out of 5 average rating, 28 reviews

Serenade Lodging Rooms

Si necesitas un lugar donde te quieras sentir en casa fuera de tu casa, Serenade Lodging Rooms te lo ofrece.Habitaciones súper cómodas,con su cocineta incluida ... todo con los mejores estándares.. Desayuno completo incluido.. delicioso y variado.. y una excelente atención pues en Serenade Lodging Rooms usted es nuestra prioridad.