
House holiday rentals in Santee
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Quick stats about house rentals in Santee

Nightly prices starting at
Santee holiday rentals start at €86 per night before taxes and fees

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Over 60 verified reviews to help you choose

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across Santee rentals

4.9 Average rating
Santee stays are highly rated by guests – averaging 4.9 out of 5!
Top-rated house rentals in Santee
Guests agree: these houses are highly rated for location, cleanliness and more.

The Grand Marshall
Bring the whole family to this renovated 3 BR, 2 bath home +1 BONUS ROOM, which serves as a theatre/game room with 2 queen sleeper sofas. Your family will enjoy: Coffee/beverage/snack bar Central location: Approximately 5 minutes to SC State and Claflin University, OC Tech College, Edisto Gardens, MUSC Health Orangeburg, shopping, dining, and more. Designated office space 1 king bed, 2 queen beds, plus 2 queen sleeper sofas 5 Roku Smart TV’s Smart lock for easy access High speed WiFi

Lake House at Lake Marion
Beautiful lakefront 3 Bedrooms/2 full baths with million dollar view of Lake Marion. -2 Queen beds/2 twins/1 futon -Washer/Dryer -Screened porch -Private Dock - fish in “big water” -Canoe & Kayak -Fire pit -Includes linens & beach towels & more! -Fully Furnished + grill & carport -One level open concept -75” Roku TV & Roku in Master and WiFi -great safe neighborhood for walking & bike riding -NO HOUSE PARTIES or events. -public boat landing &county park with playground within 2 blocks.

Your home away from home in Pinopolis
Nestled at the end of a quiet cul-de-sac, this house is close to Lake Moultrie & the Cooper River. It’s also very close to popular wedding venues: Somerset Point, Pineland Village, & Old Santee Canal Park. Moncks Corner Recreational Complex, where many tournaments are hosted, is also about 3 miles away. Pinopolis is less than 20 miles from Summerville & the Volvo area, 40 miles from coastal beaches, and just 45 minutes away from Downtown Charleston. It’s a great location for work or play!

Lakefront Retreat | Dock, Firepit & Pet Friendly
Wake up to panoramic Lake Marion views, fish from your private dock, relax around the waterfront firepit, and enjoy a peaceful lakefront getaway just steps from the water. Enjoy peaceful mornings, sunset evenings, and easy access to fishing, boating, swimming, and lake life. Pet Friendly: Well-behaved pets are welcome! Please keep pets off furniture and clean up after them inside and outside the property. Multiple pets may be considered case-by-case—please message us before booking.

Luxurious Lakefront Log Home W/Pool & hot tub
Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

Pet-Friendly Lake Marion Getaway - Just off I-95!
In the quaint lakefront town of Santee, There exists a special place. Past Main street and down a country road, nestled in a modest lakefront community, with views of the majestic Lake Marion, we've worked tirelessly to create the perfect family retreat. No matter who you call family, this home is perfect for boaters, golfers, and nature enthusiasts. Guests at the Kindred Spirits Retreat experience more than just a beautiful home, they experience the joys of purposeful travel.

The G.O.A.T.s Retreat at Goat Isl w/Pool+Ramp+Pier
Experience the absolute best Lake Marion has to offer at The G.O.A.T.s Retreat at Goat Island. This ultimate family compound can house up to 22 guests in comfort and style. The salt water pool with custom waterfall wall and splash pad is conveniently located in between the main house and the pool house. Double driveway, lakeside fire pit, private boat ramp, kayaks, rooftop observation deck, private pier and more! Pull into the palm lined driveway, unpack, relax and enjoy!

Sunny Santee Stay · 5BR Cityview · Lake & Golf
Brand new 2025 modern, cozy home near interstate I95, golf courses, markets, local restaurants (Cracker Barrel Old Country Store, Starbucks, etc) and Lake Marion. Santee is right in the middle distance between Miami and New York. Clean and stylish space with two 75” smart TVs, Wi-Fi, full amenities, and easy self check-in. Relax with the whole family at this new clean, quiet, safe and peaceful neighborhood. View our profile to explore more homes in the area.

Cheerful 3 bedroom home on the lake
Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Sunset Serenity Pool/Swim Spa
Experience next-level lakefront luxury in this brand-new 5BR/3BA custom home featuring a massive open-concept layout, chef’s kitchen, two master suites, and resort-style amenities like 20x40 infinity pool, swim spa, and fire pit. Enjoy a private dock, multiple lounge spaces, dual laundry sets, paddleboard/kayaks, and designer finishes throughout. Every detail of Sunset Serenity was designed for comfort, beauty, and unforgettable moments on Lake Marion.

Lake Marion | Chill, Cruise, or Cast a Line for 8!
Wake up to quiet mornings, sip coffee by the water, cast a line, and let the day slow down. This Lake Marion home is all about relaxing, fishing, and unplugging with your favorite people. This is the perfect place to reset, recharge, and enjoy the simple things. No rush. No noise. Just lake life, done right. PS: this IS a fresh water lake in SC with a lot of wildlife, including alligators...swim, fish, and play at your own risk.

Boogs Cabin at Lake Marion
Boogs Cabin at the Lake is your cozy, laid back getaway on the big water of Lake Marion. With three comfortable bedrooms (1 King 2 Queen), bonus game room that also has a pull-out full bed and two sleeping cots, large sliding glass doors in the living room that invite natural light in and offer views of the great outdoors it's the perfect place to play, recharge and reconnect.
Popular amenities for house rentals in Santee
House rentals with a pool

Heated Indoor Pool on Lake Marion with Dock

Lakeview Leisure-Face to the Sun

Lakefront Retreat | Pool + Hot Tub + Private Beach

Wyboo Retreat at Lake Marion W/Pool

Luxe Lake Marion Oasis with Pool/Hot Tub/Dock

Lake Marion - Majestic Big Water Views

Lakefront Lookout

Quiet Retreat:Secluded & Idyllic
Weekly house rentals

Lake House for Perfect Getaway

Lakefront home with boat ramp and game room

Viridian Retreat

A Lake front house: large yard, community lake.

Lured Away to our lakefront home

The Back Nine Bungalow

Large Lakefront Home w/360 view, beaches & dock

Almost Heaven on Lake Marion, SC
Private house rentals

Sunny Santee Stay | 3BR Retreat near Lake & Golf

Fishing, boating, sunrises, peace & quiet, firepit

Spacious 3BR 1/2 Mile From Lake

Lakefront vacation….bam!

Santee/Lizzie's Creek Lakefront

Tie One On! at 4 Bdr Waterfront Lake Marion

Cozy Church Branch Cabin

Furnished 3BR Near MUSC, SC State & Claflin
Destinations to explore
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- University of South Carolina
- North Charleston Coliseum & Performing Arts Center
- Congaree National Park
- Riverbanks Zoo and Garden
- Magnolia Plantation & Gardens
- Williams Brice Stadium
- Middleton Place
- Cypress Gardens
- South Carolina State House
- South Carolina State Museum
- West Columbia Riverwalk Park and Amphitheater
- Columbia Museum of Art
- Colonial Life Arena
- Sesquicentennial State Park
- Columbia Metropolitan Convention Center
- Wannamaker County Park
- Edventure
- Riverfront Park
- Soda City Market
- Whirlin' Waters Adventure Waterpark
- Koger Center for the Arts
- Segra Park
- Charleston Southern University
- Azalea Park





