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Guest house holiday rentals in Santa Cruz de la Sierra

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Top-rated guest house rentals in Santa Cruz de la Sierra

Guests agree: these guest house rentals are highly rated for location, cleanliness and more.

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Private room in Santa Cruz de la Sierra

Mirador del Cielo - Boutique Aparthotel 2

Sky Apartment es ideal para viajeros que buscan un lugar cómodo, elegante y con todas las comodidades para disfrutar al máximo su estadía. A solo 15 minutos del Aeropuerto Internacional de Viru Viru y con acceso fácil a las principales zonas de la ciudad. Relájate en la piscina ubicada en el último piso, disfruta del jacuzzi, sauna seco y de vapor, o prepara una deliciosa parrillada con amigos y familiares ¡Te esperamos para que vivas una experiencia única en Santa Cruz de la Sierra!

A cozy living space is presented with a comfortable sectional sofa featuring decorative cushions. A coffee table sits in front, with a sleek television mounted on a modern cabinet. Natural light enters through large windows, and a potted plant adds a touch of greenery.
Guest house in Santa Cruz de la Sierra

Horizontal duplex in backyard of house with pool

Disfruta de un duplex adosado (completo) horizontal en el patio trasero de mi casa. Con propio ingreso al duplex, comparte ingreso a propiedad. Ubicado en una zona segura y tranquila de fácil acceso, cercano a comercios, mercados, supermercados, farmacia, transporte público (a cuadras de las avenidas principales), en auto a 10 min. del centro, 5 min. de la Fexpo, 30 a 40 min. del aeropuerto, a 1 cuadra caminando de la sociedad de ingenieros SIB, clínica Montalvo y Urbari.

A multi-story building is showcased, featuring a distinctive red facade with decorative archways. Balconies extend from the upper floors, providing outdoor space. The ground level houses various storefronts, while utility poles and street signs are visible, indicating a lively urban environment.
Guest house
4.42 out of 5 average rating, 12 reviews

Cozy family home in Santa Cruz de la Sierra

Family house of 320 square meters, on the second floor, with all the utensils and home clothes, wonderful views from its 30 meters of terrace. Ideal for families who want to have a quiet stay of any duration in the City of Santa Cruz de la Sierra. Very well connected with several bus lines that take you to the entire city and surroundings and very close to the Santuario de Cotoca. Nearby has all kinds of services, breakfasts, meals, markets, shops, etc.

A spacious common area features comfortable seating arrangements with a mix of sofas and chairs. A central table is set with placemats, while a ceiling fan and air conditioning unit contribute to a comfortable environment. Light filters through large windows, enhancing the welcoming feel.
Guest house in Santa Cruz de la Sierra

Spacious house with a patio and parking

Casa de huéspedes, con patio amplio y parrilla (churrasquera), en una zona muy tranquila. Aire acondicionado en todos los ambientes, termotanque (agua caliente), Wi-Fi, amplia sala de estar. Suite con baño privado. Baño común, sofá-cama y sofa amplio en planta baja. (Pueden dormir cómodamente hasta 4 personas) Dirección: km 8, Barrio 14 de Agosto, Calle 3 Entre doble vía la guardia y radial 17 y medio

Guest favourite
Private room in Centro
4.86 out of 5 average rating, 7 reviews

Room in the center, two minutes from everything!

Experience staying in the heart of Santa Cruz, just 3 blocks from the main square. Our bright and cosy room awaits you in a safe and lively area: museums, cafes, bars, shops and historical spots are just a few steps away. Ideal for those looking for comfort, style and an unbeatable location. With WiFi, details designed for your relaxation and a service that will make you feel at home.

Guest house

Complete centric apartment with garden and pool

Complete centric apartment with an enormous garden and pool. Private apartment with fully staffed kitchen, private bathroom and a bedroom with a queensized bed. You'll also have access to the big garden and the pool to relax and refresh yourself. By choosing our accommodation, you’re also supporting Ñañope, a local NGO dedicated to empowering household workers in Santa Cruz.

A well-equipped kitchen features wooden cabinets and a countertop with colorful tiles. A small refrigerator and an oven are included, alongside a wooden dining table with four chairs, creating a functional space for meal preparation and dining.
Guest house in Santa Cruz de la Sierra
5 out of 5 average rating, 56 reviews

Lodge surrounded by nature in the city

We renewed our lodge for more comfort for our guests: Imagine a little house surrounded by trees and plants, easy to go and not far away from city center. We´re living on half a hectar and your new place for working o relaxing is inside this paradise. You´re completely independent from us, with all you need for taking a rest or work, including the swimming pool.

Private room in Centro
4.5 out of 5 average rating, 4 reviews

Double or Full Room in Downtown

New and elegant building located just 2 blocks from the main square, surrounded by shopping malls, restaurants, cafes, jewelry, jewelry, perfumerias, it is located a couple of blocks from the house of culture, the cathedral, museums, 1 block, banks, 7 streets market and various shops and locals.

Private room in Santa Cruz de la Sierra

Bedroom#4 with private bathroom

Enjoy the simplicity of this quiet and central accommodation. 5 blocks from the monument "El Cristo" five minutes from the city center. 50 metres from the main Cristo Redentor avenue, where multiple transport lines pass.

Guest favourite
A cozy bedroom features a spacious bed dressed in neutral linens, accompanied by decorative cushions. Two wooden chairs are positioned beside a round table near a window with light curtains. A wooden nightstand stands beside the bed, contributing to the room's welcoming atmosphere.
Guest house in Centro
4.88 out of 5 average rating, 112 reviews

Private Apartment In Downtown

Welcome to our cozy guest house in one of the most beautiful and safe areas of the center! Just 6 blocks from Plaza 24 de Septiembre, our historic neighborhood offers you a unique experience.

Guest house in Santa Cruz de la Sierra

Casa Portal Holístico # 1

Disfruta de este espacio místico de tranquilidad y armonía dónde tus noches serán restauradas y revitalizantes con la energía del Portal Holístico

Private room in Santa Cruz de la Sierra

Apartment-style room

Desconecta de tus preocupaciones en este espacio tan amplio y sereno.

Popular amenities for guest house rentals in Santa Cruz de la Sierra

Quick stats about guest house rentals in Santa Cruz de la Sierra

  • Total holiday rentals

    Explore 50 holiday rentals in Santa Cruz de la Sierra

  • Nightly prices starting at

    Santa Cruz de la Sierra holiday rentals start at € 9 per night before taxes and fees

  • Verified guest reviews

    Over 350 verified reviews to help you choose

  • Pet-friendly holiday rentals

    Find 10 rentals that welcome pets

  • Rentals with dedicated workspaces

    20 properties have a dedicated workspace

  • Wifi availability

    50 of Santa Cruz de la Sierra holiday rentals include wifi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi and Pool across Santa Cruz de la Sierra rentals

Destinations to explore