
Guest house holiday rentals in La Mesa
Find and book unique guest house rentals on Airbnb
Quick stats about guest house rentals in La Mesa

Total holiday rentals
Explore 90 holiday rentals in La Mesa

Nightly prices starting at
La Mesa holiday rentals start at €44 per night before taxes and fees

Verified guest reviews
Over 7,160 verified reviews to help you choose

Family-friendly holiday rentals
10 properties offer extra space & child-friendly amenities

Pet-friendly holiday rentals
Find 20 rentals that welcome pets

Holiday rentals with a pool
10 properties feature pools

Rentals with dedicated workspaces
50 properties have a dedicated workspace

Wifi availability
90 of La Mesa holiday rentals include wifi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across La Mesa rentals

4.9 Average rating
La Mesa stays are highly rated by guests – averaging 4.9 out of 5!
Top-rated guest house rentals in La Mesa
Guests agree: these guest house rentals are highly rated for location, cleanliness and more.

Private 1 BR Paradise Retreat
Private, yet central. It is your exclusive paradise retreat to enjoy from your spacious 1 bedroom guest house located on the lower level of our home. Hang out in the expansive and private backyard with pool, different sitting areas and covered BBQ room. Or maybe a workout in the gym. Centrally located in the Village of La mesa. Just a 1/4 mile jaunt into the quaint village with its numerous assortments of dining options, stores and trolley station. Freeway close to beaches, downtown and airport
4.99 out of 5 average rating, 182 reviews
Anna's Historic Stone Cottage w/panoramic View!
Welcome to Anna's Historic Stone Cottage! The 110 year old cottage has been transformed into the perfect combination of romantic and rustic for a dream-worthy getaway. The 280sq ft cottage features stunning, panoramic views of the San Diego skyline while offering rooftop seating for sunrise and sunset viewing. The Cottage is conveniently located 20 minutes from the world famous San Diego zoo and most other must-see, tourist spots. Amenities for special occasions offered too. Check out our menu!
4.91 out of 5 average rating, 475 reviews
Da Hui Hut - La Mesa’s best view and spa
Da Hui Hut is a very private oasis uniquely situated at the top of San Diego county's magnificent Mt. Helix. At roughly 1,300 feet above sea level, Mt. Helix is the crown jewel of natural landmarks in the area. The landscape provides bountiful views, and the large deck is positioned perfectly to see it all. It feels like you're on top of the city! Inside, guests will encounter Californian and Hawaiian inspired decor as they collide with wooden walls to compose a symphony of color and good vibes.
4.96 out of 5 average rating, 266 reviews
NEW construction - Studio by Village of La Mesa
New studio - Attached Dwelling Unit (ADU) with a private entrance. Walking distance to the Village of La Mesa which has several restaurants, shops and a Vons. Very close to SDSU and quick access to multiple freeways that take you to beaches, mountains, SD Zoo, the nightlife in downtown SD (8, 94, 125). Access to shared laundry room, 2 parking spaces and its own outdoor area. AC & heat. WiFi. Netflix, Hulu with live TV, Apple TV, Disney +, Prime Video and HBO Max. Crib and high chair upon request
4.98 out of 5 average rating, 160 reviews
East Watch- a private getaway
East Watch is a 740 sq ft, 1 bedroom private retreat that provides the comforts and amenities of home with the style of a high-end hotel. All 5 to 15 min from shopping, downtown, and the beach. It's a short walk from Mt. Helix Park which offers a 360* view, weekday yoga, and stunning sunrises and sunsets. We have EV high speed car charging, a full kitchen with all appliances, workspace with dedicated fast WIFI, a spa shower, and super comfortable beds and pillows. Stay and let us charm you!
4.98 out of 5 average rating, 133 reviews
Vacation Paradise-Heated Pool+Hot Tub+FirePit+EV
Welcome to your personal resort! This is your private Guest House with a salt & heated pool + hot tub. Located in a very quiet & safe neighborhood in beautiful San Diego. Drive 15 minutes to the beach, downtown, La Jolla, Zoo, stadiums, Sea World, Convention Center + more. Hike next door at Cowell Mountain or Lake Murray. Smart TV, wifi, two zone AC, full kitchen, W/D combo, top quality finishes & furniture. Everything you need for memorable vacation! No smoking or vaping on the property.
4.97 out of 5 average rating, 179 reviews
Stunning Guest House 15 min. from Zoo, Downtown
Stunning guest house that's 15 minutes to San Diego Zoo + downtown San Diego. The cottage is decorated with mid-century and one-of-a kind furniture in a comfy living space overlooking a gorgeous garden. Enjoy the the garden on your private deck, watch TV while relaxing in the handcrafted Nicaraguan rocker or 1950s Danish slipper chair. The cottage also has a comfy queen-sized bed and a full kitchen that's stocked with what you'd need. Oh, and all guests arrive to a homemade loaf of bread.
4.99 out of 5 average rating, 232 reviews
SDCannaBnB #1 *420 *parking *dog-friendly *hot tub
Welcome to SDCannaBnB - San Diego's premier cannabis-friendly rental! Our casita is newly remodeled with luxury ammenities. We proudly cater to the cannabis community and non-users alike. Our casita has HEPA air purifiers, is fully ventilated and receives deep cleanings between each guest. This ensures that every guest checks into a clean, fresh-smelling place that feels like home. Our casita is located in our quiet, fully fenced in backyard, close to San Diego's attractions
4.99 out of 5 average rating, 383 reviews
Enchanting private Mt Helix retreat close to SDSU
This quiet retreat (5 min. from the quaint main street of downtown La Mesa) used to be a doll workshop. Drink your morning ritual on a private deck amongst the trees. 15 min. from downtown and SD airport. 10 minutes from SDSU. 25 minutes to La Jolla/ beaches and most San Diego colleges and attractions like Birch Aquarium. 15 minutes from Balboa Park museums. Hike Mission trails-15 min. from trailheads. Take a walk up scenic Mt Helix and enjoy the vistas. Flora and fauna abound.
4.98 out of 5 average rating, 113 reviews
Beautiful Bright Mt. Helix Studio
This beautiful newly remodeled studio is in the heart of Mt Helix, a unique community in San Diego close to freeways, shopping, dining and more. Mt. Helix is called the lungs of San Diego because of it's lush surroundings and unique lots. We are surrounded by citrus orchards and are on a mountain giving you beautifully fantastic views. We are located in a private and quiet community just minutes from everything SD is so famous for.
5.0 out of 5 average rating, 113 reviews
San Diego Newly Built Private Guesthouse (Sleep 4)
Newly built one-bedroom private guesthouse w/view of Cowles Mountain and separate street entrance. Living room has queen futon. A 50" smart TV with YouTube TV. Free high-speed Wi-Fi. Kitchen with refrigerator, stove, oven, microwave, dishwasher, toaster, and Keurig coffee machine. Bedroom has queen bed and 40" smart TV. Bathroom has large shower and electronic bidet. Washer/dryer. Allow small pets up to 35 lbs. for $20 fee.
4.95 out of 5 average rating, 193 reviews
Private Detached Modern Studio located in La Mesa
**Cleaned and disinfected following COVID-19 guidelines provided by CDC/Airbnb** Modern studio with private entry, walking distance from stores, shops, restaurants, and parks. Cozy for a couple and sleeps up to 5. Feel at home with your own private laundry, full size kitchen, and private bath. 3 minutes from Highways 125, 94, and 8. Centrally located and less than 15 minutes from downtown San Diego.
4.92 out of 5 average rating, 359 reviewsPopular amenities for guest house rentals in La Mesa
Family-friendly guest house rentals

La Cabana
4.93 out of 5 average rating, 234 reviews
The Happy Family * 2 playhouses & baby gear
5.0 out of 5 average rating, 208 reviews
Cozy Coop with a View
4.96 out of 5 average rating, 231 reviews
Private Poolside Cabana
5.0 out of 5 average rating, 433 reviews
Fig Tree Bungalow
4.93 out of 5 average rating, 278 reviews
Spacious, private Mt. Helix country style studio
4.99 out of 5 average rating, 304 reviews
Fletcher Hills - modern 1 BR.Easy, no step access.
4.98 out of 5 average rating, 257 reviews
Granny Flat with Bedroom/Bathroom/Kitchen
4.94 out of 5 average rating, 187 reviewsGuest house rentals with a patio

Loft Cabin•SoakTub•FirePit• Cinema•View+Zoo add-on
4.98 out of 5 average rating, 232 reviews
Cozy Hillside Retreat with View
4.93 out of 5 average rating, 107 reviews
Cozy ADU in San Diego’s suburban rural mix area.
4.98 out of 5 average rating, 164 reviews
SDSU Central Cozy Casita | Fast WiFi | Walkable
4.96 out of 5 average rating, 174 reviews
AmazingVIEWS! Hilltop Guest House with XL Balcony~
4.99 out of 5 average rating, 112 reviews
Violet Oasis | hot tub + kitchen, dog friendly!
4.96 out of 5 average rating, 138 reviews
San Diego Mountain Retreat
4.98 out of 5 average rating, 115 reviews
Beach views for 2! Jacuzzi, fire pit
4.95 out of 5 average rating, 127 reviewsGuest house rentals with a washing machine and dryer
*BEAUTIFUL* Sunny Home in Golden Hill
4.94 out of 5 average rating, 435 reviews
STUNNING Casita with a View!!
4.89 out of 5 average rating, 243 reviews
Private SD Guesthouse 20 Min to Beaches & Downtown
4.99 out of 5 average rating, 110 reviews
The “OUT” House: Artist’s Loft/Studio
4.94 out of 5 average rating, 175 reviews
Mt Helix Studio Loft with Mountain Views
4.97 out of 5 average rating, 224 reviews
Modern mountain guest house. Incredible views
4.99 out of 5 average rating, 231 reviews
The Golden Hill mosaic "casita"
4.87 out of 5 average rating, 568 reviews
Beautiful Historic Home and Gardens Near Downtown!
4.97 out of 5 average rating, 300 reviewsWhen is the best time to visit La Mesa?
| Month | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sept | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Avg. price | €101 | €101 | €104 | €110 | €113 | €119 | €124 | €110 | €102 | €105 | €105 | €100 |
| Avg. temp | 15°C | 15°C | 16°C | 17°C | 18°C | 20°C | 21°C | 22°C | 22°C | 20°C | 17°C | 14°C |
Destinations to explore
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- Rentals with a hot tub La Mesa
- Rentals with pools La Mesa
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- Family-friendly rentals La Mesa
- Pet-friendly rentals La Mesa
- Rentals with breakfast La Mesa
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- House rentals La Mesa
- Guest house rentals San Diego County
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- SeaWorld San Diego
- Coronado Beach
- Rosarito Beach
- LEGOLAND California
- University of California-San Diego
- Petco Park
- San Diego Zoo
- San Diego Convention Center E Ent
- San Diego Zoo Safari Park
- Pacific Beach
- San Diego State University
- Balboa Park
- Tijuana Beach
- Pechanga Resort Casino
- Torrey Pines State Beach
- Mission Beach
- Las Olas Resort & Spa
- Ocean Front Walk
- Anza-Borrego Desert State Park
- Oceanside City Beach
- La Misión Beach
- Moonlight State Beach
- Belmont Park
- Sesame Place San Diego





