
Villa holiday rentals in La Mesa
Find and book unique villas on Airbnb
Top-rated villa rentals in La Mesa
Guests agree: these villas are highly rated for location, cleanliness and more.

1/2Acre•Lux•Pickleball•Pool•SPA•PIT•ARCADE•Grill
Make dreams come true w/ this Upgraded Luxury Oasis, packed w/ 100+ amenities. From the stunning pool/spa, to the playground & arcades, a memorable vacation is waiting for you. A double master suite house, 2 kitchens, 2 laundry rooms on a half acre for the whole family to enjoy. Book Now 😊 18 min - San Diego Airport🛬/Downtown San Diego🏟️ 17 min - Balboa Park/Zoo🦁 22 min - Mission Beach/Pacific Beach 🏖️ 20 min - Mexico 🇲🇽 border 10 min - Berona Casino🎰 5 min - Lake Jennings🎣 22 min - Sea World🐳

The Kensington Canyon Estate
Beautifully restored Kensington retreat blending historic charm with modern luxury. Approaching its 100th anniversary, this home has undergone a complete $250,000 renovation, offering the comforts of brand-new construction while preserving its timeless character. Located on quiet Hart Drive in one of San Diego’s most beloved historic neighborhoods, guests can enjoy tree-lined streets and walkable cafés, restaurants, and shops—just minutes from beaches, Balboa Park, downtown, and top attractions.

*Huge HelixCastle-PanoramicView/20+guests welcome
Welcome to our exquisite 5-bedroom (3 stories) home in the desirable neighborhood of Mount Helix in San Diego! This stunning residence is the perfect blend of modern elegance and exceptional comfort, making it an ideal choice for your stay in America's Finest City. Whether you're visiting San Diego for a family vacation, a romantic getaway, or a business trip, our Mount Helix castle, provides the perfect setting for an unforgettable stay. Book your stay with us today to create lasting memories!

6-bed Paradise Villa Pool, hot-tub massage chair
*EV charging available Welcome to Casa Cerro-my incredible chic high-tech modern villa in San Diego! This stylish place to stay is perfect for families and group trips. Its open and airy layout can accommodate up to 14 people. This completely remodeled home is furnished with all the luxuries of home and more that is powered by an iPad for you to use. I love technology. But don't worry you don't have to use it to power up the house, everything has traditional switches/remotes if you choose.

@Fantastic villa, giant pool, guest house, golf !
This unique fantastic villa with a separate pool house sitting on 1 acre with a spacious living space with large windows. Main house has 4 bedrooms with 2 baths, and a guest house has 1 bedroom with 1 bath. +8 car parking, nice privacy and a fantastic view! Brand new giant size SALT pool with huge size jacuzzi, pool toys, golf zone, a huge grass event field, game field, pool table, foosball, ping pong, Nitendo,2 fire pits and more! Truly one-of-a-kind property don’t miss out! ToT:COSD-00749

Villa Bermuda Beach
NEW CEMENT STEPS TO SANDY BEACH BELOW--(City installed in May 2024). Safe accessible steps to the sandy beach below Villa Bermuda Beach. The steps are located one property north of Villa Bermuda Beach. Contemporary Oceanfront Retreat Overlooking Pacific Ocean and Accessible White Sand Beach Below the Oceanfront Deck Exceptions to the general "No Pets Rule" can be requested. There is a non-refundable pet fee of $495 per pet that is charged on each pet that is brought to Villa Bermuda Beach.

Hidden Villa with Beautiful Furnished Garden Patio
Close to everything, quiet and private. This beautiful 2 Bd Villa seems to be loved by all who stay here. The outdoor private patio feels like your in the forest. Gorgeous custom bath with large marble shower. Full size laundry. Great entertainment system, Roku, Amazon Prime. The home has open beam ceilings, lots of light and a fabulous patio fully furnished for guests, outdoor dining and barbecuing. The home is private, fenced, furry friends are welcome. 2 gig internet w/high speed router

Historic Villa, Blocks from the Beach, Ocean Views
Built in 1923, this beach town retreat has tons of old world charm with all the modern amenities. Only 6 blocks to the beach, you couldn't ask for a better location. Dog Beach, Sunset Cliffs and some of the best bars, restaurants and vintage shops in all of San Diego are just outside your doorstep. ☞ 3 Bedrooms ☞ Private Hot Tub ☞ Private Swimming Pool ☞ Outdoor Dining ☞ Ocean Views (perfect for sunset cocktails) ☞ Outdoor Grill ☞ Bikes to enjoy the neighborhood ☞ Chef's Kitchen

Sunset Lounge in SDSU | Pool •HotTub •Outdoor TV•
☀️Welcome to your luxurious San Diego getaway! ☀️ This spacious 5-bedroom, 2-bathroom 2-level home is perfect for groups and families. Dive into the sparkling blue pool, unwind in the 6-person hot tub, or relax in the cozy outdoor seating areas. Enjoy stunning views from the balcony overlooking the pool, perfect for sunsets. With a central location, plenty of space to relax, and a mix of comfort and elegance, this home is ideal for exploring or unwinding on your San Diego adventure!

Casa Charles, Tropical backyard, Pool & Pizza oven
This beautiful family home is a entertainment paradise with a large gourmet kitchen with plenty of pots and pans, dished and kitchen ware, even the spices to cook up a delicious family dinner. but you'll be sure to enjoy the tropical backyard with a bocce court, that includes a pool, a hot tub, an outdoor wood fireplace, a gas fire pit and even a wood fire pizza oven - You're freeway close to everything San Diego has to offer when you stay at this centrally-located retreat.

Gorgeous Beach Villa | Ocean Views + Sleeps 12!
Experience the ultimate family retreat in our spacious 6-bedroom, 4-bath home with breathtaking views of Mission Bay and the Pacific Ocean. Perfect for groups, it features two kitchens, multiple balconies, and a large backyard with a fire pit and grill. Walk to Ocean Beach and Sunset Cliffs or explore nearby attractions like SeaWorld and Balboa Park. Unwind with sea breezes, sunsets, and the sparkle of SeaWorld fireworks. Your unforgettable San Diego getaway starts here!

Beautiful house in mira mesa
Get ready to enjoy a bright and spacious home right in the heart of Mira Mesa! Just 20 minutes from downtown, the airport, top attractions, and plenty of shopping, it’s the perfect spot for large families or groups of friends eager to experience the best of San Diego. Here, you’ll feel right at home while soaking up all that sunny San Diego has to offer For your safety,security camera in the front door
Popular amenities for villa rentals in La Mesa
Private villa rentals

San Diego villa for quiet & calm relaxation.

The Bonita Bungalow

Sunset Lounge in SDSU | Pool •HotTub •Outdoor TV•

Casa Charles, Tropical backyard, Pool & Pizza oven

1/2Acre•Lux•Pickleball•Pool•SPA•PIT•ARCADE•Grill

1stResorts.com AMAZING WATER VIEW PENTHOUSE HOTTUB

Hidden Villa with Beautiful Furnished Garden Patio

6-bed Paradise Villa Pool, hot-tub massage chair
Luxury villa rentals

1stResorts.com 2 WATERVIEW FAMILY VILLAS HOTTUB AB

Amazing WaterView Penthouse w/AC

Spacious 4BD | La Jolla • Ocean Views • Jacuzzi

3680 Bayside Walk, A Bayside Marina

Cheerful 4-bedroom villa with free parking.

Large house with beautiful bay views
Villa rentals with a pool

10AcreVilla,Heated*SaltPool,MtnView,Mini-Golf,BBQ

1 PRIVATE OCEAN VIEW ROOM IN LUXURY COASTAL HOUSE

Fun Get Away, Vaulted Ceiling, Pool, Hot Tub, New.

TWO OCEAN VIEW ROOMS-Quiet Luxury Coastal Retreat

Private oasis

Apartment in hilltop villa: Torrey Pines Suite
Quick stats about villa rentals in La Mesa

Total holiday rentals
Explore 10 holiday rentals in La Mesa

Nightly prices starting at
La Mesa holiday rentals start at € 51 per night before taxes and fees

Verified guest reviews
Over 490 verified reviews to help you choose

Family-friendly holiday rentals
10 properties offer extra space & child-friendly amenities

Holiday rentals with a pool
10 properties feature pools

Rentals with dedicated workspaces
10 properties have a dedicated workspace

Wifi availability
10 of La Mesa holiday rentals include wifi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across La Mesa rentals

4.7 Average rating
La Mesa stays receive an average rating of 4.7 out of 5 from guests
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- Rosarito Beach
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