
House holiday rentals in La Mesa
Find and book unique houses on Airbnb
Top-rated house rentals in La Mesa
Guests agree: these houses are highly rated for location, cleanliness and more.

Family Fun! Game Garage + Big Yard + Free Parking
Embodying the epitome of cool! This home has the perfect blend of a vintage feel with a modern touch. Stepping inside, you’re greeted by an atmosphere of fun & creativity. A large private serene retreat in the backyard w/abundant seating and fire pit. Huge 3-car garage bonus space with games. Located just minutes from downtown La Mesa, many dining options & conveniences. Everything you need & more! Distance to: San Diego Zoo: 18 min Sea World: 23 min SDSU: 13 min Airport: 19 min Gaslamp: 18 min

XTRA 10% OFF until Nov: Pool, outdoor fire pits, c
Find your family's dream spot in San Diego! Our cozy house sits on a quiet hill, offering privacy and amazing sunset views. Dive into our pool year-round (heating at an additional cost), roast marshmallows by the fire, and cook up fun meals together. With 3 bedrooms and 2 bathrooms, it’s perfect for families, accommodating up to 9 guests. Plus, we're close to all the best attractions. Want a vacation you'll always remember? Send us a message to make it happen! 🌅🏠 We have 3 comfy beds that can

Hidden King Suite with Garden, Parking - 4 Guest
Capture the essence of San Diego in our Hidden King Suite with Garden hosted by Ethos Vacation Homes. The peaceful property features elite comfort for up to 4 guests with beautiful outdoors and garden, off-street parking, A/C and heating, FREE laundry, comfortable king and queen size beds, plenty of sheets and towels, a large HDTV, Netflix, Max, Hulu, Showtime, Disney+, Apple+, and ESPN+. This spacious San Diego vacation rental home has everything you need for your California Dreaming Vacation!

Sunny & Spacious 3BR Retreat w/ Parking & A/C
Centrally located in La Mesa is this newly refurbished home ideal for business or pleasure with all of life’s little luxuries waiting for you to enjoy. The home features open concept living with a gourmet kitchen, a chic dining space, 3 beautiful bedrooms, 2 modern bathrooms and an expansive yard with an outdoor lounge. Walk 10 mins to Grossman Center with a Target, restaurants, cafes, a cinema & Walmart or drive to the heart of San Diego and all its attractions just 20 mins from your door.

Travel Writer's Pad
Hello, Bonjour, Hola, Ciao, Ni Hao! For the past two decades my career as a travel journalist has taken me around the globe. I’ve stayed at thousands of accommodations, where I learned personal touches create a comfortable home away from home. Certain places I visited offered extra special amenities, such as Green tea at a Japanese Ryokan & chardonnay infused bath salts at a Mexican posada. These kinds of touches are in the home. I welcome you, but no parties or events at the house. Thanks!

Clean 1BR/1BA Guest House Peaceful Private Casita
Discover the perfect home away from home in San Diego! Our cozy and tranquil guest house is located just a short drive from the city's top attractions, including the San Diego Zoo and beautiful beaches. Relax and unwind in the comfortable living room and enjoy all the amenities you need for a peaceful stay. With a comfortable queen-sized bed, full kitchen, and fresh towels, you'll have everything you need to feel at home. Book your stay with us today and experience the best of San Diego!

Cottage in the Garden! New! Modern!
COTTAGE IN THE GARDEN - New! Modern! Find beauty and serenity in this special guest house in one of San Diego's most desirable areas! Flowering bushes, plants, olive tree and fruit trees seen from all windows. All amenities: WiFi, Cable, serving dishes and tableware, full coffee bar, Ninja Blender, Flat screen TVs, 100% Egyptian Cotton Sheets or Boll and Branch Sheets (used by 3 Presidents), Japanese Toilette and more. 15 minutes to Downtown San Diego and 20 minutes to the beach!

Zen Retreat: 3-Bedroom Oasis near La Mesa Village
Relax in this charming 3-bedroom, 1-bathroom home located just 1 mile from the heart of Historic Downtown La Mesa Village. Nestled in a quiet, central neighborhood, this cozy retreat offers easy access to major freeways, top-rated restaurants, and the local trolley line making it a breeze to explore the best of San Diego. Within 10 to 15 miles, you’ll find yourself in iconic destinations like Downtown San Diego, Balboa Park, Coronado Island, scenic beaches, and beautiful mountain trails.

SDCannaBnB #2 *420 *parking *dog-friendly *hot tub
Welcome to SDCannaBnB - San Diego's premier cannabis-friendly rental! Our studio is newly remodeled with luxury ammenities. We proudly cater to the cannabis community and non-users alike. Our studio has HEPA air purifiers, is fully ventilated and receives deep cleanings between each guest. This ensures that every guest checks into a clean, fresh-smelling place that feels like home. Our studio is located in our quiet, fully fenced in backyard, close to San Diego's attractions

(Relist!) Relax at a Stunning 1931 Historic Tudor!
Come & enjoy our 1931 historic tudor home! Beautifully rebuilt within the last 2 years. This house has a huge front lawn and space to roam. Enjoy the serenity this large property has to offer. Three peaceful patios to enjoy your morning coffee. The kitchen has an 48-inch 1950’s oven for the chef in the family. Bay windows, arched entryways and original light fixtures make this such a charming place to stay. Centrally located to enjoy everything San Diego & La Mesa has to offer.

Peaceful Casita | Firepit • Near SDSU
Welcome to our cozy home, perfect for couples visiting the area. It's also a great spot for SDSU parents visiting their kids. Conveniently close to the campus but far enough to enjoy some peace and quiet. If you enjoy this listing, click the heart icon ❤ in the top-right corner to bookmark it for easy access! Minutes from key attractions: ★ 6 min to SDSU/Viejas Arena ★ 14 min to Balboa Park ★ 17 min to Downtown SD (Gaslamp) ★ 19 min to San Diego Zoo ★ 21 min to the Airport

Charming La Mesa Home
**Home cleaned and disinfected following COVID-19 guidelines provided by CDC/Airbnb** Charming 3 bed, 1 bath. Feel at home with your own private laundry, full size kitchen, spa like bathroom and private office/workspace. This place is perfect for both work and leisure getaways. Walking distance from stores, shops, restaurants, and parks. 3 minutes from Highways 125, 94, and 8. Centrally located and less than 15 minutes from downtown San Diego.
Popular amenities for house rentals in La Mesa
House rentals with a pool

3BR Urban Oasis - Pool and Hot Tub | San Diego

Casa Bahia Beautiful San Diego Home with Pool

Bright and spacious home with views, pool & spa.

University Heights Oasis Getaway

Custom Guesthouse, Balboa Park/Zoo/Hillcrest& pool

Updated TownHome, Great Location, Fantastic Views

Heated Pool-Jacuzzi-King Bed-City Views-Chic Decor

Dream Vacation! Sunny 3 Bedroom Home!
Weekly house rentals

Shadow House Mt. Helix

Airbnb Luxe: The Perfect Blend of Access & Escape

Discover La Mesa: Your Perfect Cozy Base

Helix Haven

XLarge Artist's Retreat w/private patio/parking

Modern, Private, & Stylish Home

Entire house, fenced yard, and driveway

Chic Casita•Hot tub•BBQ•Patio•4 min SDSU•CentralSD
Private house rentals

Escape to tranquility: the perfect retreat

Cozy 1BR Home with Lovely Front Yard

Serenity in San Diego

Garden Retreat in North Park.

Cozy quiet getaway, great mattress (1-br)

San Diego's Finest Retreat

Lavish pool Villa In Mt. Helix, close to beaches

Helix Pool House
When is the best time to visit La Mesa?
| Month | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Avg. price | € 154 | € 154 | € 164 | € 155 | € 159 | € 184 | € 189 | € 184 | € 147 | € 158 | € 154 | € 166 |
| Avg. temp | 15°C | 15°C | 16°C | 17°C | 18°C | 20°C | 21°C | 22°C | 22°C | 20°C | 17°C | 14°C |
Quick stats about house rentals in La Mesa

Total holiday rentals
Explore 300 holiday rentals in La Mesa

Nightly prices starting at
La Mesa holiday rentals start at € 17 per night before taxes and fees

Verified guest reviews
Over 13,300 verified reviews to help you choose

Family-friendly holiday rentals
190 properties offer extra space & child-friendly amenities

Pet-friendly holiday rentals
Find 100 rentals that welcome pets

Holiday rentals with a pool
80 properties feature pools

Rentals with dedicated workspaces
180 properties have a dedicated workspace

Wifi availability
300 of La Mesa holiday rentals include wifi access

Popular amenities for guests
Guests love Kitchen, Wifi and Pool across La Mesa rentals

4.9 Average rating
La Mesa stays are highly rated by guests – averaging 4.9 out of 5!
Destinations to explore
- Southern California Holiday rentals
- Los Angeles Holiday rentals
- Stanton Holiday rentals
- Las Vegas Holiday rentals
- Channel Islands of California Holiday rentals
- San Diego Holiday rentals
- Phoenix Holiday rentals
- Palm Springs Holiday rentals
- San Fernando Valley Holiday rentals
- Scottsdale Holiday rentals
- Henderson Holiday rentals
- Las Vegas Strip Holiday rentals
- Rentals with an EV charger La Mesa
- Guest house rentals La Mesa
- Rentals with a fireplace La Mesa
- Rentals with pools La Mesa
- Rentals with a beach view La Mesa
- Family-friendly rentals La Mesa
- Rentals with a patio La Mesa
- Rentals with a firepit La Mesa
- Rentals with outdoor seating La Mesa
- Fitness-friendly rentals La Mesa
- Rentals with a hot tub La Mesa
- Rentals with breakfast La Mesa
- Rentals with beach access La Mesa
- Private suite rentals La Mesa
- Pet-friendly rentals La Mesa
- Rentals with a washing machine and dryer La Mesa
- Smoking-friendly rentals La Mesa
- Flat rentals La Mesa
- Villa rentals La Mesa
- House rentals San Diego County
- House rentals California
- House rentals United States
- Rosarito Beach
- Oceanside City Beach
- Torrey Pines State Beach
- Tijuana Beach
- Pacific Beach
- SeaWorld San Diego
- LEGOLAND California
- University of California San Diego
- Coronado Beach
- San Diego Zoo Safari Park
- Balboa Park
- Pechanga Resort Casino
- La Misión Beach
- Oceanside Harbor
- Coronado Shores Beach
- Liberty Station
- Moonlight Beach
- Sesame Place San Diego
- Belmont Park
- Black's Beach
- Law Street Beach
- Strand Beach
- Torrey Pines Golf Course
- Santa Monica Beach