House holiday rentals in Isla Grande

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Top-rated house rentals in Isla Grande

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Guest favourite

Two rustic-style cabins are set along the shoreline, surrounded by lush tropical trees. A wide patio is furnished with colorful chairs, offering views of the water. The natural beauty of the landscape is complemented by the tranquil waves gently lapping at the shore.

Home in La Guaira

4.97 out of 5 average rating, 105 reviews

Puntita Manzanillo, fantastic sea and jungle

Come visit one of the most unique and exclusive properties in the Panamanian Caribbean. A magical completely private 5 acre property nestled between the Caribbean Sea (500meters of ocean front) and the jungle. Surrounded by a garden of corals and visited by monkeys and macaws. Our energy is solar and we have our own aqueduct. Temperature oscillates between 72 and 84 degrees F. It is rented in its entirety. It has 3 one bedroom cabins with full baths. Satellite Internet (Starlink) is provided.

Superhost

An open-concept loft is showcased with a high, sloped ceiling and large windows that invite natural light. Comfortable seating is arranged around a glass table, while a dining area and a cozy sleeping space can be seen in the background. Nature views are visible through the windows.

Home in Santa Rita Arriba

5 out of 5 average rating, 3 reviews

The Bird's Nest in the Clouds

Escape to the Clouds: A Nature Lover’s Retreat. Welcome to The Bird's Nest, a serene loft in Santa Rita Arriba, Colón, 50 minutes from the city. Perched in the mountains, this open-concept space offers breathtaking views, fresh breezes, and the sounds of nature - rain, birds, and our chickens. Sleep with doors open, no AC. Perfect for nature lovers, not for those needing silence or climate control. Pool with breathtaking view, wifi and modern comforts included. Please read description fully.

Guest favourite

A stone pathway leads through lush tropical foliage toward a welcoming entrance. Tall trees and vibrant greenery frame the path, creating a serene approach to the property, which is partially visible in the background, surrounded by nature's tranquility.

Home in Panama City

5 out of 5 average rating, 55 reviews

Mountain Retreat

Relax and unwind at this peaceful property nestled on two hectares of lush tropical vegetation surrounded by the sights & sounds of nature. Located at Panama's Blue Mountain(Cerro Azul), 30 kilometres from Panama City. This cozy & comfortable home is equipped with modern amenities & chic decorative touches. It consists of a main house with 2 bedrooms & a 2 bedroom cottage. It has a spacious terrace, pool & jacuzzi overlooking Panama City. The property also boasts its own spring water well

Top guest favourite

An outdoor terrace features a table with seating for four, framed by colorful chairs in red and blue. A hammock is suspended nearby, with the serene view of the water and distant hills providing a tranquil backdrop. Natural light illuminates the space, highlighting the coastal setting.

Home in Juan Gallego

4.96 out of 5 average rating, 50 reviews

Kasa Leilani - the perfect getaway!

Welcome to Kasa Leilani, a charming beach house nestled between the jungle and the reef in the heart of a natural park. With stunning views of the nearby Caribbean islands, this peaceful retreat offers the perfect blend of nature and comfort. Surrounded by abundant wildlife, you can relax, explore the reef, or discover the island and crystal-clear waters. Kasa Leilani provides a serene escape for nature lovers and beach enthusiasts alike, offering an unforgettable tropical getaway.

Guest favourite

A modern living area features a dark sectional sofa with a decorative pillow. Natural light filters through stylish striped blinds, highlighting the sleek marble flooring. A wooden cabinet and coffee station are positioned in the background, creating a functional and inviting space.

Home in Colón

4.92 out of 5 average rating, 24 reviews

Family Style Living, in Colon #3

Relax with the whole family at this peaceful place. This house is located on reverted Areas transferred back to Panamá, called Arco Iris, there’s plenty of space outside, the inside consist of a modern combination living room+kitchen, bathroom and a large bedroom with acomodación for 4 guest, the place is Airconditioned with Celling fans in the living room and bedroom. This is a third house constructed next to our first rental called, Family Style Living and close to the Panamá Canal

Superhost

An open living area is showcased with a kitchenette on one side, featuring dishware and utensils arranged neatly. A spacious bed is positioned against the wall, complemented by a colorful headboard. A small wooden table is surrounded by three stools, creating a casual dining space.

Home in Portobelo

4.8 out of 5 average rating, 46 reviews

Casa Dinis, Studio, Downtown Portobelo

Relax! You're in the Caribbean! The Studio is in the historic center of Portobelo, a World Heritage village, you have the opportunity to live a real experience and share with a village full of history, cultural identity and cute people! The Studio is on the low floor of Casa Dinis and has a separate entrance, it has a queen bed and a sofa bed (preferably for children). The space is very comfortable, equipped kitchen, bathroom, air conditioning, Internet and TV welcome!

Superhost

A two-story wooden house is situated by the shore, surrounded by palm trees. The structure features a combination of red and white exteriors, with air conditioning units visible on the main level. A clear blue sky and lush greenery provide a vibrant backdrop.

Home in La Guaira

4.75 out of 5 average rating, 8 reviews

Beautiful oceanfront country house

Casa de Campo facing the sea in the form of a boat.. where you can see, hear and hear the sounds of the sea of birds and nature. It has 4 alcoves with AA of which the main one has a delicious balcony overlooking the sea It is a nice place where you can enjoy hiking, fishing, boating, horseback riding, bathing in waterfalls, rivers and much more! The house is wooden and we design it as if it were an experience inside a boat, it is an ideal place to rest

Guest favourite

A spacious wooden chalet is positioned on a lush green slope, surrounded by tropical vegetation. The structure features an open terrace with railings, allowing for expansive views of the sky. A few palm trees and various plants complement the natural landscape.

Home in Cacique

4.96 out of 5 average rating, 24 reviews

El Paraiso

We are pleased to present a large beautiful house for rent between the village of Cacique and the village of José Pobre in Portobelo National Park. Overlooking the Caribbean Sea, nestled in the jungle, this house has a unique character in the area. Its direct access to a small wild beach, with an exciting reef for snorkeling fans, makes it a privileged place. Ideal for groups and families wishing to reconnect with nature.

Top guest favourite

The kitchen area features a black dining table with four chairs, complementing a modern microwave and refrigerator. Warm decorative elements, including wall art and a candle, add character to the space, which is equipped with essential appliances and a clean countertop.

Home in Panamá

4.93 out of 5 average rating, 382 reviews

Private Studio 10 Min from the Airport!

Entire apartment 10 minutes from the airport! The apartment is fully furnished including appliances and kitchen items, toiletries, dining room, work table and more. Just a few minutes walk from the SAN ANTONIO METRO Station, restaurants, shopping malls, laundries, supermarkets and pharmacies. We offer tours to San Blas to make the most of your trip. Our house is your house in Panama 🇵🇦

Top guest favourite

Home in Panama City

5 out of 5 average rating, 5 reviews

The Lake House 2025

New lakefront house in Cerro Azul, decorated by a D&G architect with furniture brought from Bali. It has 3 bedrooms, 3 bathrooms and 4 double beds, equipped kitchen, BBQ, air conditioning and hot water. Cook a delicious BBQ with your friends in front of the lake and enjoy the sunsets from an unparalleled view with direct access and kayak included.

Superhost

An aerial view captures a serene bay bordered by lush tropical greenery. A small boat is anchored in the clear waters, and a spacious house is situated near the beach, surrounded by trees and open land, creating a harmonious natural setting.

Home in Playa Blanca

4.75 out of 5 average rating, 73 reviews

Sparrow's Point

Un lugar paradisiaco que muestra al caribe panameño en su mejor esplendor!! La playa de arena blanca protegida por una bahía de aguas cristalinas y enmarcada por la selva tropical crean un idílico contraste entre el verde del follaje y el azul de la laguna. Despierte a 10 pasos del mar.

Guest favourite

The image captures a serene beachfront view with gentle waves lapping at the shore. Lush palm trees line the sandy beach, leading to a charming property featuring a thatched roof. A clear blue sky provides a tranquil backdrop, enhancing the natural beauty of the surroundings.

Home in La Guaira

4.78 out of 5 average rating, 86 reviews

La casa de la guaira (Oceanfront)

Escape to a paradise in the Panamanian Caribbean at our beach house. Designed to provide you with a relaxing and rejuvenating experience,our property offers a perfect balance between comfort and nature.