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Holiday rentals in Isla Grande

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Isla Grande

Guests agree: these stays are highly rated for location, cleanliness and more.

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Guest favourite
Two rustic-style cabins are set along the shoreline, surrounded by lush tropical trees. A wide patio is furnished with colorful chairs, offering views of the water. The natural beauty of the landscape is complemented by the tranquil waves gently lapping at the shore.
Home in La Guaira

Puntita Manzanillo, fantastic sea and jungle

Come visit one of the most unique and exclusive properties in the Panamanian Caribbean. A magical completely private 5 acre property nestled between the Caribbean Sea (500meters of ocean front) and the jungle. Surrounded by a garden of corals and visited by monkeys and macaws. Our energy is solar and we have our own aqueduct. Temperature oscillates between 72 and 84 degrees F. It is rented in its entirety. It has 3 one bedroom cabins with full baths. Satellite Internet (Starlink) is provided.

4.97 out of 5 average rating, 115 reviews
Guest favourite
The image captures a serene beach scene featuring a sandy shoreline and clear turquoise waters. Thatched-roof gazebos are visible near the water, alongside a wooden pier extending into the sea. Various boats are moored in the distance, surrounded by tropical greenery.
Holiday home in Maria Chiquita

Dreamy, Modern Caribbean Home at Playa Escondida

Have fun with the whole family at Casa Capri, a dreamy place which is a perfect fit both for adults & kids. The apartment is at Playa Escondida, a stylish resort with white sand beaches and crystal clear ocean water, several amenities such as a restaurant (with a broad range of great food, including fresh seafood and sushi!), pools to chill or swim, plus fantastic and diverse children playgrounds. Whether you'd like to have a resting vacation or a fun getaway, Casa Capri got you covered. Enjoy!

4.86 out of 5 average rating, 103 reviews
Superhost
An aerial view showcases a rustic cottage surrounded by lush palm trees, located near a sandy beach. The gentle waves of the ocean are visible, along with several red-roofed structures nestled within the greenery, creating a serene coastal atmosphere.
Cottage in Palenque

Beachfront House in Caribbean sandy beach

Enjoy this rustic and cozy cottage with its almost private beach surrounded by beautiful palm trees along the whole area. With 2 oceanview bedrooms, 2 full bathrooms and a third bedroom in a mezzanine. Has a patio with a built in uruguayan parrilla, ideal for BBQs. Step in beautiful white sand and bath in crystal clear water. Coconut breakfasts watching the sunrise become a routine in this paradise. - This is a rural setting. Not a 5 star hotel. Insects and small animals can be around.

4.88 out of 5 average rating, 96 reviews
Top guest favourite
An outdoor terrace features a table with seating for four, framed by colorful chairs in red and blue. A hammock is suspended nearby, with the serene view of the water and distant hills providing a tranquil backdrop. Natural light illuminates the space, highlighting the coastal setting.
Home in Juan Gallego

Beachfront · Large Sea View · Family Friendly

Welcome to Kasa Leilani, a charming beach house nestled between the jungle and the reef in the heart of a natural park. With stunning views of the nearby Caribbean islands, this peaceful retreat offers the perfect blend of nature and comfort. Surrounded by abundant wildlife, you can relax, explore the reef, or discover the island and crystal-clear waters. Kasa Leilani provides a serene escape for nature lovers and beach enthusiasts alike, offering an unforgettable tropical getaway.

4.94 out of 5 average rating, 99 reviews
Top guest favourite
An inviting infinity pool overlooks a stunning coastal view. A spacious seating area, featuring colorful cushions, complements the serene atmosphere. Natural light fills the space, enhancing the connection to the outdoors, while the blue waters of the pool blend seamlessly with the distant ocean.
Villa in Cacique

FACING THE SEA Cacique (Portobello Park)

A house! A real glass island in the heart of the jungle! In the middle of the Portobello National Park (access only by 4x4 AWD) nestled at the top of the hill, between sky/sea, away from all eyes, a transparent house where glass embraces nature on all sides creating a unique connection between the inside and the outside, ideal for resting, disconnecting, comfortable, spacious, cool (central air conditioning), exclusive. It is the witness of a grandiose spectacle that awaits you!

4.98 out of 5 average rating, 58 reviews
Guest favourite
A serene swimming pool is depicted surrounded by lush palm trees, with the tranquil sea visible in the background. The water's clear blue tiles reflect the sky and nearby greenery, while the gentle curvature of the pool edge invites relaxation.
Villa in Portobelo

Entire Villa with pool in front of beach!

Beautiful spacious 4 bedroom villa right in front of the sea. Enjoy the swimming pool with your family, then take a dip into the sea only steps away. Very pet friendly! Take a boat trip for the day with a local certified tour guide from portobelo town. Every room has full AC, including the living room - but please be conscious of the environment when using ACs. Excellent WiFi ! Open Kitchen, with breakfast included. We can also arrange for lunch - fresh lobster!

4.97 out of 5 average rating, 88 reviews
Superhost
Home in Isla Grande

Beachfront House + Kitchen + Balcony + AC + Wi-Fi @ Isla Grande

✔️Verified Superhost Your stay will be in the best hands! 🚨Send us a message with the word DISCOUNT and ask about special promotions 📍 Apartment in Isla Grande, Colón Province, Panama 🇵🇦 🏡 Clean, comfortable and safe space, great location 🧼 Equipped with supplies and cleaning supplies During your booking, your Airbnb has: 🌐Wi-Fi. 📺TV 🍳Kitchen Ocean 🌊front ❄️A/C 🚗Parking 👉Send us a message with the word DISCOUNT and ask for promotions

5.0 out of 5 average rating, 4 reviews
Top guest favourite
The balcony offers expansive views of the ocean and nearby coastline, with palm trees visible along the shore. The scene features clear blue water meeting the sky, creating a serene atmosphere. Light hardwood flooring is present indoors, enhancing the open space leading to the outdoor area.
Flat in Maria Chiquita

Sunrise Caribbean at Playa Escondida Resort & Marina

Welcome to our inviting beachfront condo at Playa Escondida Resort & Marina in Maria Chiquita, Panama. Indulge in stunning ocean vistas from the private balcony, direct beach entry, and refreshing pools. Ideal for both relaxation and adventure seekers. Stay connected with complimentary high-speed WiFi, and indulge in your favorite shows or movies on the flat-screen TV. Reserve your tropical escape today and experience the beauty of Panama's coastline!

5.0 out of 5 average rating, 92 reviews
Top guest favourite
A bright living area features large glass doors that provide a panoramic view of the beach and ocean. A spacious sectional sofa is positioned near natural light, complemented by a wooden dining table. Elegant decor elements include woven light fixtures and fresh greenery.
Apartment in Maria Chiquita

Playa Escondida with the Best Direct Ocean View

Wake up to the Caribbean blue from your private balcony, coffee in hand. Enjoy direct beach access, breathtaking ocean views, and a peaceful escape just one hour from the city. 4 rooms & 4 bathrooms ⭐ Premium - Fully stocked kitchen - In-unit washer and dryer - Nespresso/Drip/French Press coffee machine - High-speed WiFi - Ergonomic desk and office chair - Baby crib - High chair (baby)

4.99 out of 5 average rating, 95 reviews
Top guest favourite
Home in Maria Chiquita

‘Beautiful and Comfortable Villa at Playa Escondida Resort’

Luxury Resorts and Villa, front lagoon view and beach only 2 minutes away. Enjoy a comfortable and peaceful stay in this fully equipped accommodation, ideal for couples, families, small groups or business travellers. It can accommodate up to 6 guests, offering a cosy, clean and functional environment, and a large terrace, for a pleasant stay without a doubt.

4.97 out of 5 average rating, 65 reviews
Superhost
An outdoor seating area is presented with four woven chairs positioned around a rectangular table. The view reveals a serene sea in the background, with a well-kept grassy area and scattered rocks leading to the water's edge. Bright sunlight enhances the peaceful atmosphere.
Home in La Guaira

Casa "El Terrenito" - Ocean Front

Spacious waterfront house with 2 bedrooms, one room with 3 queen beds and 2nd with a king and a twin. Kitchen, living room, dining room. It has all the utensils for kitchen, sheets, stove,refrigerator, A/C. Special to relax!! For fishing fans we can provide a fishing panga! Additional price per day and captain. You can bring a pet.

4.69 out of 5 average rating, 186 reviews
Superhost
Home in Palenque

Casa Palenque Panama

Enjoy a spectacular oceanfront house, ideal for groups and families of up to 14 people. Relax with direct beach views, spacious indoor and outdoor spaces, and all the amenities for an unforgettable stay. Perfect for relaxing, socialising and creating unique memories with the sound of the sea in the background. We are pet friendly.

4.64 out of 5 average rating, 11 reviews

Popular amenities for Isla Grande holiday rentals

Frequently Asked Questions

  • Where is Isla Grande located?

    Isla Grande is situated just off Panama's northern Caribbean coast, in Colón Province. It is found near the entrance to the Portobelo National Park area, surrounded by tropical waters and natural scenery.

  • When is the best time to visit Isla Grande?

    Travelers frequently suggest visiting Isla Grande during the dry season for clearer skies and calmer seas. The rainy months bring lush landscapes and a quieter atmosphere, with both offering distinct ways to experience the island.

  • What are some things to do near Isla Grande?

    You can explore sandy beaches, snorkel around coral reefs, and experience local seafood restaurants on Isla Grande. The island also has relaxed walking paths and is known for welcoming Afro-Caribbean cultural influences and music.

  • How is the weather near Isla Grande?

    Isla Grande typically has a warm, humid tropical climate year-round, with temperatures often between 77 and 88°F (25 and 31°C). Rain is common outside of the dry season, and brief showers can occur throughout the year.