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Holiday rentals in Santo Domingo

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santo Domingo

Guests agree: these stays are highly rated for location, cleanliness and more.

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Superhost
Home in Playa Venao
4.83 out of 5 average rating, 23 reviews

Stylish Tiny Home - with Sea View and Bathtub

Live Tiny. Connect Big. Welcome to Tiny Samambaia — a modern tiny house located in Playa Venao, just 5 minutes from the beach. Enjoy ocean views, a fully equipped kitchen, a romantic outdoor hot tub, and the sounds of birds and monkeys in the surrounding jungle. Sustainably built is the perfect escape for surfing, relaxing, or remote work w' reliable Starlink Wi-Fi. Note: Occasional power outages may occur due to the remote location. No generator is available. Thank you for understanding.

Superhost
A sunset over the ocean is captured, reflecting golden hues across the water. The shoreline is visible with gentle waves lapping at the beach. A portion of the house is seen in the foreground, surrounded by greenery and colorful flowers.
Flat in Las Tablas
4.6 out of 5 average rating, 81 reviews

2nd floor Beach Apartment with Amazing Views!

Enjoy beach life all year round in Panama at Uverito Beach! Go to the beach anytime you want, it is literally at your footsteps or relax in a hammock. This 2 bedroom 1 bath 2nd floor unit has all the amenities that will make your stay comfortable. Long-term rental is also available plus electricity (except long-term rental of 28 days or more you pay), you get a smart TV, unlimited bandwidth Wi-Fi internet, hot water shower, and brand new kitchen appliances to include a dishwasher.

Guest favourite
Flat in Las Tablas
4.94 out of 5 average rating, 17 reviews

Loft Conivan-Las Tablas

Enjoy Las Tablas as if you were at home in this spacious and comfortable full apartment. Located on the first floor. Equipped for short or long stays, with a full kitchen, cozy living room, air conditioning and WiFi, ideal for all types of travelers. Beaches, restaurants, supermarkets, and the town's main tourist attractions are just a few minutes away. Whether you're coming for a celebration, rest, or a walk, this home is the perfect starting point to enjoy Las Tablas.

Guest favourite
A bright bedroom is displayed, featuring a spacious bed covered with a textured white blanket. A television is mounted on the wall opposite the bed. Natural light floods through large windows, accompanied by sheer curtains. A cozy orange chair and potted plant add a touch of warmth.
Tiny home in Playa El Jobo
4.94 out of 5 average rating, 48 reviews

Private Beach Studio · Sunset & Nature Views

Designed for comfort, functionality, and a welcoming atmosphere: • Comfortable bed for a truly restful sleep • Air conditioning • Wi-Fi • Kitchen • 2 Bathrooms • Parking Perfect for short stays or longer breaks. Wake up at your leisure, enjoy a relaxing coffee, stroll to the beach, or simply unwind in this space. This place is ideal for: • Romantic getaways • Personal retreats • “Work from the beach” • Escaping the hustle and bustle of the city

Superhost
Home in Playa Venao
4.9 out of 5 average rating, 77 reviews

Casa Pelicano - Tropical house w pool and seaview

Welcome to Casa Pelicano! Indulge yourself in a retreat with breathtaking views of the ocean and mountains from every corner. Unwind in the private refreshing pool, where the turquoise waters seem to blend seamlessly with the horizon. The stylish interior features open-plan living spaces, perfect for entertaining or relaxing. Whether you're soaking up the sun or gazing at the moonlit ocean under the stars, this home is your ultimate escape.

Guest favourite
Flat in La Pasera
4.86 out of 5 average rating, 7 reviews

Comfortable apartment in Las Tablas, quiet area

A new apartment, very comfortable and with luxurious furnishings, designed for a welcoming and elegant stay. Located in a quiet area of Las Tablas, 7 minutes from the park and 15 minutes from the beaches. It features very comfortable beds with high-end mattresses and high-quality hotel sheets for a restful night's sleep. It has a coworking area and a TV with streaming. Fully equipped kitchen. Ideal for enjoying with complete peace of mind.

Guest favourite
A refreshing swimming pool sits in the foreground, complementing the rustic building behind it. Lush greenery and potted plants surround the area, enhancing the natural setting. A shaded patio area with outdoor seating is visible, offering a serene environment for relaxation.
Guest house in La Enea
4.96 out of 5 average rating, 55 reviews

Country House with Pool in La Enea de Guararé

Far from the capital city, come and enjoy Panamanian folklore in a rustic but cozy space, living an indigenous experience. Relax in the pool or rest in a hammock, breathe fresh air, near the sea, surrounded by spacious and natural gardens for a good walk. Close to the Port of Guararé where you can enjoy the best seafood and drinks or enjoy the heart of the best folklore event highlighting the traditions and the best Panamanian skirts.

Guest favourite
Place to stay in Pedasí
4.86 out of 5 average rating, 14 reviews

A Good Walk-Pedasi

Una Buena Caminata is a quiet, spacious villa designed as a retreat base—where days unfold slowly and logistics are handled with care. Set between the town center and Playa El Arenal, the gateway to Isla Iguana, the property offers both connection and seclusion in equal measure. This is not a resort and not a hands-off rental. It is an intentionally curated space for guests who value privacy, ease, and thoughtful living.

Top guest favourite
An outdoor space features a small pool surrounded by grass and stone flooring. A covered patio provides sleek bar stools and a grill, complemented by vibrant greenery and tropical plants. Large windows allow natural light to enhance the inviting entrance.
Townhouse in Pedasí
4.98 out of 5 average rating, 87 reviews

Beach house in Pedasí

This brand new house in the village of Pedasí offers 2 bedrooms with private bathrooms and showers and a large living room with kitchen. In addition there is a swimming pool with wellness area with grill and a covered patio behind, perfect for resting or working. The house is a 5-minute drive to different beaches, including Playa El Arenal where you can take the boat to Isla Iguana.

Superhost
A spacious sleeping area features a large bed with a white comforter, flanked by two woven pendant lights. Natural wood accents are present in the furniture, including a slatted wooden ceiling and a wall-mounted television, with large windows allowing ample natural light.
Cabin in Playa Venao
4.92 out of 5 average rating, 62 reviews

Dos Mares Venao Village - Cabin

Disconnect from your routine and enjoy nature. Our cabins are spacious, comfortable, stylish, and high quality. The king-size bed invites you to rest. We also have a double sink, TV, shower, separate bathroom, and a large terrace. You can enjoy the best breakfasts at our bar. If you wish, we can also take it directly to your cabin - however you want it!

Top guest favourite
The exterior of a modern casita is visible, featuring a combination of wood and dark siding. Large glass windows provide unobstructed views of the surroundings. A shaded outdoor seating area is present, surrounded by lush green plants, creating a welcoming entrance.
Tiny home in Playa Los Destiladeros
4.94 out of 5 average rating, 90 reviews

Brisa del Mar Cottage

Casita Brisa del Mar ~ Welcome to this special space which we have poured our hearts, souls, hopes and dreams into creating. 2 minute walk from one of the most beautiful beaches in Panama. Pacific Ocean views from every room (except the bathroom). We are also a drive away from limitless adventures on the Azuero Peninsula.

Top guest favourite
A comfortable living area is presented with a soft gray sofa paired with dark accent pillows. A wooden coffee table rests on a patterned rug, while a television is positioned on a low wooden stand. Natural light filters through sheer curtains, illuminating the wooden floors.
Cabin in Las Escobas del Venado
5.0 out of 5 average rating, 16 reviews

Luxury Cabin / Venao Beach

Welcome to our luxury cabin! features two comfortable bedrooms, each with two single beds, air conditioning, a cozy living room, and a fully equipped kitchen. The cabin is located a 2-minute drive from the beach, offering the perfect balance: close enough to enjoy the coast, yet far enough to ensure peace and tranquility.

Popular amenities for Santo Domingo holiday rentals