
Holiday rentals in Santo Domingo
Find and book unique accommodation on Airbnb
Top-rated holiday rentals in Santo Domingo
Guests agree: these stays are highly rated for location, cleanliness and more.

Stylish Tiny Home - with Sea View and Bathtub
Live Tiny. Connect Big. Welcome to Tiny Samambaia — a modern tiny house located in Playa Venao, just 5 minutes from the beach. Enjoy ocean views, a fully equipped kitchen, a romantic outdoor hot tub, and the sounds of birds and monkeys in the surrounding jungle. Sustainably built is the perfect escape for surfing, relaxing, or remote work w' reliable Starlink Wi-Fi. Note: Occasional power outages may occur due to the remote location. No generator is available. Thank you for understanding.

2nd floor Beach Apartment with Amazing Views!
Enjoy beach life all year round in Panama at Uverito Beach! Go to the beach anytime you want, it is literally at your footsteps or relax in a hammock. This 2 bedroom 1 bath 2nd floor unit has all the amenities that will make your stay comfortable. Long-term rental is also available plus electricity (except long-term rental of 28 days or more you pay), you get a smart TV, unlimited bandwidth Wi-Fi internet, hot water shower, and brand new kitchen appliances to include a dishwasher.

Loft Conivan-Las Tablas
Enjoy Las Tablas as if you were at home in this spacious and comfortable full apartment. Located on the first floor. Equipped for short or long stays, with a full kitchen, cozy living room, air conditioning and WiFi, ideal for all types of travelers. Beaches, restaurants, supermarkets, and the town's main tourist attractions are just a few minutes away. Whether you're coming for a celebration, rest, or a walk, this home is the perfect starting point to enjoy Las Tablas.

Private Beach Studio · Sunset & Nature Views
Designed for comfort, functionality, and a welcoming atmosphere: • Comfortable bed for a truly restful sleep • Air conditioning • Wi-Fi • Kitchen • 2 Bathrooms • Parking Perfect for short stays or longer breaks. Wake up at your leisure, enjoy a relaxing coffee, stroll to the beach, or simply unwind in this space. This place is ideal for: • Romantic getaways • Personal retreats • “Work from the beach” • Escaping the hustle and bustle of the city

Casa Pelicano - Tropical house w pool and seaview
Welcome to Casa Pelicano! Indulge yourself in a retreat with breathtaking views of the ocean and mountains from every corner. Unwind in the private refreshing pool, where the turquoise waters seem to blend seamlessly with the horizon. The stylish interior features open-plan living spaces, perfect for entertaining or relaxing. Whether you're soaking up the sun or gazing at the moonlit ocean under the stars, this home is your ultimate escape.

Comfortable apartment in Las Tablas, quiet area
A new apartment, very comfortable and with luxurious furnishings, designed for a welcoming and elegant stay. Located in a quiet area of Las Tablas, 7 minutes from the park and 15 minutes from the beaches. It features very comfortable beds with high-end mattresses and high-quality hotel sheets for a restful night's sleep. It has a coworking area and a TV with streaming. Fully equipped kitchen. Ideal for enjoying with complete peace of mind.

Country House with Pool in La Enea de Guararé
Far from the capital city, come and enjoy Panamanian folklore in a rustic but cozy space, living an indigenous experience. Relax in the pool or rest in a hammock, breathe fresh air, near the sea, surrounded by spacious and natural gardens for a good walk. Close to the Port of Guararé where you can enjoy the best seafood and drinks or enjoy the heart of the best folklore event highlighting the traditions and the best Panamanian skirts.

A Good Walk-Pedasi
Una Buena Caminata is a quiet, spacious villa designed as a retreat base—where days unfold slowly and logistics are handled with care. Set between the town center and Playa El Arenal, the gateway to Isla Iguana, the property offers both connection and seclusion in equal measure. This is not a resort and not a hands-off rental. It is an intentionally curated space for guests who value privacy, ease, and thoughtful living.

Beach house in Pedasí
This brand new house in the village of Pedasí offers 2 bedrooms with private bathrooms and showers and a large living room with kitchen. In addition there is a swimming pool with wellness area with grill and a covered patio behind, perfect for resting or working. The house is a 5-minute drive to different beaches, including Playa El Arenal where you can take the boat to Isla Iguana.

Dos Mares Venao Village - Cabin
Disconnect from your routine and enjoy nature. Our cabins are spacious, comfortable, stylish, and high quality. The king-size bed invites you to rest. We also have a double sink, TV, shower, separate bathroom, and a large terrace. You can enjoy the best breakfasts at our bar. If you wish, we can also take it directly to your cabin - however you want it!

Brisa del Mar Cottage
Casita Brisa del Mar ~ Welcome to this special space which we have poured our hearts, souls, hopes and dreams into creating. 2 minute walk from one of the most beautiful beaches in Panama. Pacific Ocean views from every room (except the bathroom). We are also a drive away from limitless adventures on the Azuero Peninsula.

Luxury Cabin / Venao Beach
Welcome to our luxury cabin! features two comfortable bedrooms, each with two single beds, air conditioning, a cozy living room, and a fully equipped kitchen. The cabin is located a 2-minute drive from the beach, offering the perfect balance: close enough to enjoy the coast, yet far enough to ensure peace and tranquility.
Popular amenities for Santo Domingo holiday rentals
Other great holiday rentals in Santo Domingo

Earth House Pedasi Experience

Beachfront home on Playa Venao + private pool

Enjoy a beach house with a sea view and patio

Family home for 9 | 3 bedrooms | Los Santos

House in the center of Las Tablas

Villas Donde Chika Apt #3 | Downtown Las Tablas

House for groups near Las Tablas and beaches

3- Las Tablas Comfy and Spacious Private Room
Destinations to explore
- Panama City Holiday rentals
- Cahuita Holiday rentals
- Quepos Holiday rentals
- Bahía Ballena Holiday rentals
- Puerto Viejo de Talamanca Holiday rentals
- Bocas del Toro Province Holiday rentals
- Uvita Holiday rentals
- Boquete Holiday rentals
- Rio Hato Holiday rentals
- El Valle Holiday rentals
- Cartago Holiday rentals
- Valle de Antón Holiday rentals





