Mansion holiday rentals in Panama
Find and book unique mansions on Airbnb
Top-rated mansion rentals in Panama
Guests agree: these mansions are highly rated for location, cleanliness and more.
Holiday rentals for every style
Get the amount of space that is right for you
Popular amenities for Panama mansion rentals
Luxury mansion rentals
Flat in Panama City
4.9 out of 5 average rating, 30 reviewsPenthouse deluxe, 360º views and glass pool
Home in Río Hato
4.95 out of 5 average rating, 75 reviewsEspectacular casa frente al mar en Buenaventura!
Villa in Panamá
5.0 out of 5 average rating, 31 reviewsBreathtaking Views Mansion w/King Beds
Villa in Buenaventura, El Chirú
4.8 out of 5 average rating, 15 reviewsLake House | Pool | King Beds | Next to Beach Club
Villa in Playa Venao
4.98 out of 5 average rating, 61 reviewsCasa Aqua: Amazing beach front house - Playa Venao
Flat in Maria Chiquita
4.95 out of 5 average rating, 20 reviewsPenthouse en Playa Escondida 4 recamaras
Villa in Bejuco
4.96 out of 5 average rating, 78 reviewsBeach house at Punta Chame, Villa frente al mar
Villa in Punta Chame
4.92 out of 5 average rating, 13 reviewsFREE NIGHT Amazing Beachfront Villa - Palm House
Pet-friendly mansion rentals
Home in Playa Bluff
5.0 out of 5 average rating, 16 reviewsJungle House 100m from the beach
Flat in San Carlos District
4.99 out of 5 average rating, 79 reviewsIncreíble departamento Oceanfront en San Carlos
Cottage in Altos del Maria
4.93 out of 5 average rating, 99 reviewsCabaña con Espectacular Vista a las Montañas
Home in Gamboa
4.86 out of 5 average rating, 88 reviewsBirdHouse@ Gamboa Panamá Canal
Villa in Portobelo
5.0 out of 5 average rating, 42 reviewsEntire Villa with pool in front of beach!
Villa in Costa Esmeralda
5.0 out of 5 average rating, 13 reviewsEspectacular casa de playa frente al mar de 600mts
Home in San José
5.0 out of 5 average rating, 18 reviewsαlkeyler| Luxury Mini Resort 12 PERS @Punta Barco
Villa in Bocas del Toro
5.0 out of 5 average rating, 56 reviewsCasa del Mar - eco aqua villa
Mansion rentals with a pool
Flat in Panamá
5.0 out of 5 average rating, 21 reviewsTop Floor Condo 6 bedroom with amazing views
Apartment in Maria Chiquita
5.0 out of 5 average rating, 19 reviewsPlaya Escondida Lux Beachfront Haven:Oceanview Apt
Flat in Maria Chiquita
4.97 out of 5 average rating, 59 reviewsSpacious 4Br Beachside Getaway at Playa Escondida
Flat in Río Hato
5.0 out of 5 average rating, 18 reviews4 Bedroom Private Pool Paradise in Buenaventura
Home in Cacique
5.0 out of 5 average rating, 19 reviewsEl Paraíso
Home in Provincia de Panamá Oeste
4.88 out of 5 average rating, 17 reviewsLujosa casa frente a la playa en Veracruz
Home in Pedasí
4.83 out of 5 average rating, 6 reviewsOcean View From The Jungle!
Home in Río Hato
4.98 out of 5 average rating, 96 reviewsComplete House for a Perfect Stay
Destinations to explore
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