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House holiday rentals in Mesa County

Find and book unique houses on Airbnb

Top-rated house rentals in Mesa County

Guests agree: these houses are highly rated for location, cleanliness and more.

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Top guest favourite
A private hot tub is illuminated with soft blue light, positioned under a shelter. A cozy seating area features comfortable chairs adjacent to a fire pit, with warm flames flickering. Twinkling string lights provide a welcoming ambiance against the night sky.
Home in Palisade
4.93 out of 5 average rating, 308 reviews

Peach Pad! hot or cool tub 2 bedrooms 2 bathrooms

Sandstone views, outdoor area with private hot tub, can be kept cool in hot weather just message your preference. Bedrooms with en-suite bathrooms and are situated on opposite sides of the home for privacy. 7-10 minute bike ride to downtown, 5-10 minute walk to three vineyards,. Orchard surrounds 900 sq ft bedrooms and the living room have smart TVs, the kitchen is well equipped. The fenced yard has shaded outdoor areas to BBQ and enjoy sunsets. Best for 4 guests comfortable roll away bed for 5.

Guest favourite
A hot tub is situated on a patio area, surrounded by a white fence. Two hanging egg chairs provide cozy seating. Soft landscape lighting reflects off the water, with a twilight sky featuring distant clouds and a colorful sunset in the background.
Home in Grand Junction
4.89 out of 5 average rating, 216 reviews

420Friendly_HotTub_12kGameArcade_WineBar_5Bed

✨This is 420 Friendly home and you are welcome to smoke and use any marijuana products you would like in the comfort of the house. (no tobacco) I provide smoking accessories that are clean and sanitized after each guest and kept safe in a kitchen cabinet out of reach of kids. Dogs are welcome with a $50 fee. ⭐Multiple Wineries ➡15 min drive ⭐Mesa University ➡5 min drive ⭐Airport➡ 5 min drive ⭐Downtown GrandJunction ➡8 min drive ⭐Amtrak Train Station➡10 min drive ⭐Palisade Orchards ➡15 min d

Guest favourite
A rustic carport features a vintage vehicle with weathered paint, under a metal roof. An American flag hangs from one post, while colorful hanging planters add a touch of greenery. The surrounding open area is dotted with sparse grass and low shrubs.
Home in Orchard City
4.94 out of 5 average rating, 613 reviews

The Orchard House

**A devastating freeze in October 2020 killed all 400 of our sweet cherry trees and many of our peach trees. Sadly, our orchard is not the lush green jewel it once was. We are planting new cherry trees in the Spring of 2022. While the orchard views have changed, the Orchard House continues to offer a very comfortable place to rest and recharge. Come enjoy fresh air and quiet whether you are stopping through on a road trip or staying longer for local adventure. Fast WiFi for telecommuting!

Top guest favourite
An aerial view captures the unique architecture of the home against the backdrop of the Colorado National Monument. Surrounding natural vegetation blends with the rugged terrain, while a winding driveway leads to the house, showcasing its integration within the landscape.
Home in Grand Junction
4.93 out of 5 average rating, 216 reviews

5200SqFt, Hillside Rock In House, Stunning Views

One of a kind 4BR 3BA 5,200 sqft home. Stunning views of the CO Ntl Mnt and entire Grand Valley. Our grandpa, a home builder, designed this rustic house as a masterpiece for his family. He wanted it to be part of nature, so he fit it between trees and inside left exposed the massive sandstone slab on which it’s built. This large house has entertained our family and friends for generations, and we’re thrilled that now you can share it with yours, too. Be in nature but minutes from downtown!

Top guest favourite
A bright bedroom features a large bed adorned with a soft blanket and decorative pillows. Leaf-patterned wallpaper creates a vibrant backdrop, while two lamps add a warm glow. An air conditioning unit and a round mirror are also visible, contributing to the room's inviting atmosphere.
Home in Grand Junction
4.99 out of 5 average rating, 188 reviews

Dog friendly 2 blocks to Main! Art on White Suite!

✨2 blocks to Main Street! Art on White Suite gives you an artistic, vintage, downtown experience with access to world-class mountain biking, winetasting, and much more! Our vintage home built in 1905, has quite a unique experience to offer. With love for our Community and Art, this eclectic space provides a relaxing, whimsical, light & airy stay. This 2 bedroom, one bath suite is attached to the main house- very private with a lovely back yard! We love this space and we hope you do too! 😊

Guest favourite
Home in Palisade
4.92 out of 5 average rating, 258 reviews

The Pali House - 10 Acres & Wine Country Views

Welcome to The Pali House, a recently renovated 2-bed, 2-bath retreat on 10 private acres in Palisade wine country. Panoramic views, wrap-around porch, king bed, and the best stargazing in Colorado. Five minutes to wineries and dining, 40 minutes to Powderhorn. Designed for travelers seeking space, privacy, and stunning Western Slope sunsets. The home is extra large for groups of 4 and is fully stoked with everything you need to make Palisade home for a trip away. Your hosts, Joe & Trish

Top guest favourite
A panoramic view captures dramatic mountain ranges under a dynamic sky, with soft light highlighting the peaks. Shadows and sunlight create a range of tones across the landscape. In the foreground, greenery and structures provide a base to the vast scenery beyond.
Home in Grand Junction
4.97 out of 5 average rating, 179 reviews

Little Park Road Retreat - Hot Tub with a View

This home is located on 2 acres just 5 minutes from downtown, but feels like you're out in the country. The panoramic views from the patio and hot tub are spectacular & ever changing. Hiking and biking are minutes away. The house has an open feeling with beautiful stone & woodwork. A large laundry/mud room offers safe storage for bikes & other outdoor equipment. Enjoy the BBQ grill out on the patio while watching amazing sunsets & visiting rabbits & birds. We now have air conditioning.

Top guest favourite
The farmhouse, featuring a classic white exterior and a sloped metal roof, is surrounded by lush greenery and colorful flower beds. A path leads from the gravel driveway to the welcoming entrance. In the backdrop, rugged cliffs rise, adding to the scenic rural setting.
Home in Palisade
4.98 out of 5 average rating, 220 reviews

A Peach of a Farmhouse

Located on the Scenic Fruit and Wine Byway, our newly remodeled air-conditioned farmhouse is on a three-acre peach farm within easy biking distance to Palisade. Enjoy downtown Palisade's farmers market, distillery, and brewery. We're moments from many wineries and trailheads including Mt. Garfield & Palisade Rim. Begin, end or spend your day lounging on the front porch in the shade of mature peach trees or enjoying views of the rugged Palisades seeming to rise just outside the back door.

Top guest favourite
A spacious porch features wooden flooring and is lined with tranquil seating options, including a set of chairs and a swing. Natural light filters through the surrounding trees, enhancing the peaceful outdoor space.
Home in Delta County
4.96 out of 5 average rating, 298 reviews

2 Bedroom Ranch House

Just a mile off of Highway 65 sits Tongue Creek Ranch. The Ranch is located in the fertile valley junction of Tongue Creek & Surface Creek. Enjoy your own private 2 bed 1 bath ranch house. Both bedrooms have a super comfy pillow top queen size bed. WIFI is a fast 1gig fiber optic line. Enjoy a full kitchen, washer and dryer, and a sofa in the family room. The front patio is always in the shade. Ask about the optional cabin on site for use as a private detached room for overflow family.

Top guest favourite
A contemporary home is presented with a wooden exterior, surrounded by a gravel area. Large glass doors offer views into the interior space. Two outdoor chairs are positioned on the patio, with wildflowers and vegetation framing the scene.
Home in Loma
4.99 out of 5 average rating, 714 reviews

Fruita/Loma Guest House at the Perfect Day Getaway

This newly constructed "Green" home is a mix of modern and country styles and will surely inspire you to enjoy all of the outdoor activities the Grand Valley has to offer. The Perfect Day Getaway house is located on a quaint farm within 8 minutes of world-class hiking, mountain and road bicycling, and river rafting. It is a great launching point for day trips to Moab and the Grand Mesa as well! It was built to maximize the southern exposure and views of the Colorado National Monument.

Top guest favourite
A wooden pergola with a dining table and chairs is situated in a garden area, framed by lush greenery. A yellow building and a red barn with a green roof are visible in the background, set against a colorful sunrise sky.
Home in Palisade
4.97 out of 5 average rating, 297 reviews

Galloway Ranch Palisade Colorado

Recent review: The best place we've ever stayed at, hands down! The location felt like a dead end road, yet close to everything. The yard had beautiful flower beds, not to mention the amazing view of Mt. Garfield! The house itself was very comfortable and had anything you can imagine in the kitchen, making a few at home dinners a breeze. Owners Note: One (1) dog 45 lbs max allowed unless an additional dog is approved in advance, please include # of people and # of dogs when booking.

Top guest favourite
A two-story wooden house is positioned in an open area, surrounded by a fence. The front porch features a railing and is accessible by a stone walkway. A backdrop of rolling hills and mountains under a blue sky is visible, enhancing the outdoor setting.
Home in Collbran
4.99 out of 5 average rating, 107 reviews

Mountain Ranch Retreat

Enjoy the beautiful Plateau Valley views from this house. This is a great launching pad for a Western Colorado adventure. Located Just 30 minutes from Vega State Park. 35 minutes from Powderhorn Ski Area. 15 minutes from the Grand Mesa. And just 45 minutes from Palisade. It is also in the center of Colorado hunting unit 421. Two bedrooms upstairs and one bathroom downstairs. Sleeps up to 6. Fully furnished kitchen for your use. all you need to bring are the groceries.

Popular amenities for house rentals in Mesa County