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House holiday rentals in Mesa County

Find and book unique houses on Airbnb

Top-rated house rentals in Mesa County

Guests agree: these houses are highly rated for location, cleanliness and more.

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Guest favourite
A hot tub is situated on a patio area, surrounded by a white fence. Two hanging egg chairs provide cozy seating. Soft landscape lighting reflects off the water, with a twilight sky featuring distant clouds and a colorful sunset in the background.
Home in Grand Junction
4.89 out of 5 average rating, 217 reviews

420Friendly_HotTub_12kGameArcade_WineBar_5Bed

✨This is 420 Friendly home and you are welcome to smoke and use any marijuana products you would like in the comfort of the house. (no tobacco) I provide smoking accessories that are clean and sanitized after each guest and kept safe in a kitchen cabinet out of reach of kids. Dogs are welcome with a $50 fee. ⭐Multiple Wineries ➡15 min drive ⭐Mesa University ➡5 min drive ⭐Airport➡ 5 min drive ⭐Downtown GrandJunction ➡8 min drive ⭐Amtrak Train Station➡10 min drive ⭐Palisade Orchards ➡15 min d

Top guest favourite
A private hot tub is illuminated with soft blue light, positioned under a shelter. A cozy seating area features comfortable chairs adjacent to a fire pit, with warm flames flickering. Twinkling string lights provide a welcoming ambiance against the night sky.
Home in Palisade
4.93 out of 5 average rating, 308 reviews

Peach Pad! hot or cool tub 2 bedrooms 2 bathrooms

Sandstone views, outdoor area with private hot tub, can be kept cool in hot weather just message your preference. Bedrooms with en-suite bathrooms and are situated on opposite sides of the home for privacy. 7-10 minute bike ride to downtown, 5-10 minute walk to three vineyards,. Orchard surrounds 900 sq ft bedrooms and the living room have smart TVs, the kitchen is well equipped. The fenced yard has shaded outdoor areas to BBQ and enjoy sunsets. Best for 4 guests comfortable roll away bed for 5.

Top guest favourite
A stylish living area features a decorative fireplace adorned with intricate tile. A modern gray armchair sits beside a round wooden table that holds books and a vase of yellow flowers, while large windows invite natural light and provide views of the outdoor landscape.
Home in Palisade
4.99 out of 5 average rating, 104 reviews

Modern Pali Farmhouse & Vineyard with hot tub

This spacious newer home with a hot tub is the perfect base for all your Palisade & Grand Valley adventures! Situated on 5 acres along the Fruit & Wine Byway, relax & take in the vineyard or mountain views from nearly every window! Go wine tasting, take a hike, go road or mountain biking, visit an orchard or lavender farm, paddle board on the Colorado river, ski at nearby Powderhorn, & more! Then after your day of adventuring enjoy the fireplace, outdoor living space, or a soak in the hot tub.

Top guest favourite
An aerial view captures the unique architecture of the home against the backdrop of the Colorado National Monument. Surrounding natural vegetation blends with the rugged terrain, while a winding driveway leads to the house, showcasing its integration within the landscape.
Home in Grand Junction
4.93 out of 5 average rating, 216 reviews

5200SqFt, Hillside Rock In House, Stunning Views

One of a kind 4BR 3BA 5,200 sqft home. Stunning views of the CO Ntl Mnt and entire Grand Valley. Our grandpa, a home builder, designed this rustic house as a masterpiece for his family. He wanted it to be part of nature, so he fit it between trees and inside left exposed the massive sandstone slab on which it’s built. This large house has entertained our family and friends for generations, and we’re thrilled that now you can share it with yours, too. Be in nature but minutes from downtown!

Guest favourite
Home in Palisade
4.92 out of 5 average rating, 258 reviews

The Pali House - 10 Acres & Wine Country Views

Welcome to The Pali House, a recently renovated 2-bed, 2-bath retreat on 10 private acres in Palisade wine country. Panoramic views, wrap-around porch, king bed, and the best stargazing in Colorado. Five minutes to wineries and dining, 40 minutes to Powderhorn. Designed for travelers seeking space, privacy, and stunning Western Slope sunsets. The home is extra large for groups of 4 and is fully stoked with everything you need to make Palisade home for a trip away. Your hosts, Joe & Trish

Top guest favourite
A spacious porch features wooden flooring and is lined with tranquil seating options, including a set of chairs and a swing. Natural light filters through the surrounding trees, enhancing the peaceful outdoor space.
Home in Delta County
4.96 out of 5 average rating, 298 reviews

2 Bedroom Ranch House

Just a mile off of Highway 65 sits Tongue Creek Ranch. The Ranch is located in the fertile valley junction of Tongue Creek & Surface Creek. Enjoy your own private 2 bed 1 bath ranch house. Both bedrooms have a super comfy pillow top queen size bed. WIFI is a fast 1gig fiber optic line. Enjoy a full kitchen, washer and dryer, and a sofa in the family room. The front patio is always in the shade. Ask about the optional cabin on site for use as a private detached room for overflow family.

Top guest favourite
A contemporary home is presented with a wooden exterior, surrounded by a gravel area. Large glass doors offer views into the interior space. Two outdoor chairs are positioned on the patio, with wildflowers and vegetation framing the scene.
Home in Loma
4.99 out of 5 average rating, 715 reviews

Fruita/Loma Guest House at the Perfect Day Getaway

This newly constructed "Green" home is a mix of modern and country styles and will surely inspire you to enjoy all of the outdoor activities the Grand Valley has to offer. The Perfect Day Getaway house is located on a quaint farm within 8 minutes of world-class hiking, mountain and road bicycling, and river rafting. It is a great launching point for day trips to Moab and the Grand Mesa as well! It was built to maximize the southern exposure and views of the Colorado National Monument.

Top guest favourite
A wooden pergola with a dining table and chairs is situated in a garden area, framed by lush greenery. A yellow building and a red barn with a green roof are visible in the background, set against a colorful sunrise sky.
Home in Palisade
4.97 out of 5 average rating, 297 reviews

Galloway Ranch Palisade Colorado

Recent review: The best place we've ever stayed at, hands down! The location felt like a dead end road, yet close to everything. The yard had beautiful flower beds, not to mention the amazing view of Mt. Garfield! The house itself was very comfortable and had anything you can imagine in the kitchen, making a few at home dinners a breeze. Owners Note: One (1) dog 45 lbs max allowed unless an additional dog is approved in advance, please include # of people and # of dogs when booking.

Top guest favourite
Home in Grand Junction
4.94 out of 5 average rating, 152 reviews

Modern Farmhouse -Historic Downtown Grand Junction

Welcome to Your Downtown Retreat — a newly remodeled historic home in the heart of Grand Junction. Perfect for family getaways, work trips, or a peaceful escape, this charming home blends modern comforts with timeless character. 📍 Walk to Downtown GJ’s best dining + shopping 🍳 Brand-new kitchen, perfect for family meals 🌿 Covered patio + beautifully landscaped backyard ☀️ Cozy sunroom for coffee, tea, reading, or relaxing ✨ Spacious master suite w/ king bed + en-suite bathroom

Guest favourite
A modern house is set against a clear night sky filled with stars. The exterior features large glass doors, providing a seamless view of the surroundings. A spacious patio area is visible, bordered by natural landscaping, creating a sense of tranquility and connection to nature.
Home in Palisade
4.97 out of 5 average rating, 176 reviews

Rapid Creek Retreat

High above the town of Palisade, nestled in the foothills of the Grand Mesa, is the Rapid Creek Retreat. Surrounded by untouched public land you will experience the true gift and grit of Colorado. Enjoy views of the big sky from sunrise to sunset and beyond for magical star gazing. We planned for this home to be ours, every detail of this home was built with intent and love. The feeling here is truly special. For those ‘rough around the edges. Sincerely, The Busch’s

Guest favourite
A modern two-story home is showcased, featuring a striking wood exterior and large front windows. A two-car garage is visible, alongside a spacious driveway. The well-manicured lawn is flanked by trees and a fully fenced area, enhancing the property's curb appeal.
Home in Grand Junction
4.97 out of 5 average rating, 118 reviews

4 beds-hot tub-yard&AirConditioning! NO XTRA FEES!

This home is a great choice for larger groups or just a few! Centrally located in Grand Junction with plenty of parking and a fully fenced yard. Two living areas and a large, fully stocked kitchen give you lots of room to stretch out. The bedrooms are designed with flexibility in mind! I've got two other properties in town right next to each other that each sleep 5 - let me know if you are interested. Now cooled by central air conditioning and mini-split system.

Superhost
A two-story house is seen from the outdoor area, featuring a patio with several chairs and tables. A gravel driveway leads to lush vineyards in the background, framed by distant mountains under a clear blue sky.
Home in Palisade
4.99 out of 5 average rating, 151 reviews

Love Orchard

You will enjoy breathtaking endless views of orchards, vineyards and the Bookcliff mountains and amazing sunsets from the bright, open great room and balcony. You may think you are in the clouds! The peace and quiet you will feel in this lovely new home will surely refresh you. Located on the fruit and wine byway, there are 6 wineries within 3 miles yet you are only 2.5 miles from downtown Palisade and its plentiful offerings. This home is calling your name!

Popular amenities for house rentals in Mesa County