
House holiday rentals in Mesa County
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Top-rated house rentals in Mesa County
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420Friendly_HotTub_12kGameArcade_WineBar_5Bed
✨This is 420 Friendly home and you are welcome to smoke and use any marijuana products you would like in the comfort of the house. (no tobacco) I provide smoking accessories that are clean and sanitized after each guest and kept safe in a kitchen cabinet out of reach of kids. Dogs are welcome with a $50 fee. ⭐Multiple Wineries ➡15 min drive ⭐Mesa University ➡5 min drive ⭐Airport➡ 5 min drive ⭐Downtown GrandJunction ➡8 min drive ⭐Amtrak Train Station➡10 min drive ⭐Palisade Orchards ➡15 min d

Modern Pali Farmhouse & Vineyard with hot tub
This spacious newer home with a hot tub is the perfect base for all your Palisade & Grand Valley adventures! Situated on 5 acres along the Fruit & Wine Byway, relax & take in the vineyard or mountain views from nearly every window! Go wine tasting, take a hike, go road or mountain biking, visit an orchard or lavender farm, paddle board on the Colorado river, ski at nearby Powderhorn, & more! Then after your day of adventuring enjoy the fireplace, outdoor living space, or a soak in the hot tub.

Resort-like Adobe At Colorado Monument!
This newly renovated adobe style home will make you feel like you’re in a resort with amazing views. Perfect for a family vacation, girls/guys trip, mountain biking trip, romantic getaway, wine tasting or just a weekend getaway this is the perfect home. Close to many outdoor activities including hiking, fishing, mountain biking, Paddle boarding/kayaking/tubing, golfing. Located 5 mins to Two Rivers and 25 mins to Palisade vineyards. We are offering the complete Colorado outdoor experience.

5200SqFt, Hillside Rock In House, Stunning Views
One of a kind 4BR 3BA 5,200 sqft home. Stunning views of the CO Ntl Mnt and entire Grand Valley. Our grandpa, a home builder, designed this rustic house as a masterpiece for his family. He wanted it to be part of nature, so he fit it between trees and inside left exposed the massive sandstone slab on which it’s built. This large house has entertained our family and friends for generations, and we’re thrilled that now you can share it with yours, too. Be in nature but minutes from downtown!

The Pali House - 10 Acres & Wine Country Views
Welcome to The Pali House, a recently renovated 2-bed, 2-bath retreat on 10 private acres in Palisade wine country. Panoramic views, wrap-around porch, king bed, and the best stargazing in Colorado. Five minutes to wineries and dining, 40 minutes to Powderhorn. Designed for travelers seeking space, privacy, and stunning Western Slope sunsets. The home is extra large for groups of 4 and is fully stoked with everything you need to make Palisade home for a trip away. Your hosts, Joe & Trish

A Peach of a Farmhouse
Located on the Scenic Fruit and Wine Byway, our newly remodeled air-conditioned farmhouse is on a three-acre peach farm within easy biking distance to Palisade. Enjoy downtown Palisade's farmers market, distillery, and brewery. We're moments from many wineries and trailheads including Mt. Garfield & Palisade Rim. Begin, end or spend your day lounging on the front porch in the shade of mature peach trees or enjoying views of the rugged Palisades seeming to rise just outside the back door.

2 Bedroom Ranch House
Just a mile off of Highway 65 sits Tongue Creek Ranch. The Ranch is located in the fertile valley junction of Tongue Creek & Surface Creek. Enjoy your own private 2 bed 1 bath ranch house. Both bedrooms have a super comfy pillow top queen size bed. WIFI is a fast 1gig fiber optic line. Enjoy a full kitchen, washer and dryer, and a sofa in the family room. The front patio is always in the shade. Ask about the optional cabin on site for use as a private detached room for overflow family.

Fruita/Loma Guest House at the Perfect Day Getaway
This newly constructed "Green" home is a mix of modern and country styles and will surely inspire you to enjoy all of the outdoor activities the Grand Valley has to offer. The Perfect Day Getaway house is located on a quaint farm within 8 minutes of world-class hiking, mountain and road bicycling, and river rafting. It is a great launching point for day trips to Moab and the Grand Mesa as well! It was built to maximize the southern exposure and views of the Colorado National Monument.

Galloway Ranch Palisade Colorado
Recent review: The best place we've ever stayed at, hands down! The location felt like a dead end road, yet close to everything. The yard had beautiful flower beds, not to mention the amazing view of Mt. Garfield! The house itself was very comfortable and had anything you can imagine in the kitchen, making a few at home dinners a breeze. Owners Note: One (1) dog 45 lbs max allowed unless an additional dog is approved in advance, please include # of people and # of dogs when booking.

Modern Farmhouse -Historic Downtown Grand Junction
Welcome to Your Downtown Retreat — a newly remodeled historic home in the heart of Grand Junction. Perfect for family getaways, work trips, or a peaceful escape, this charming home blends modern comforts with timeless character. 📍 Walk to Downtown GJ’s best dining + shopping 🍳 Brand-new kitchen, perfect for family meals 🌿 Covered patio + beautifully landscaped backyard ☀️ Cozy sunroom for coffee, tea, reading, or relaxing ✨ Spacious master suite w/ king bed + en-suite bathroom

Quaint Farmhouse on Palisade Peach Orchard
Quaint 3 bedroom 1 bath farmhouse located on a 5 1/2 acre working peach orchard in the heart of fruit & wine country. Nice walk or bike ride to wineries, orchards, & shuttle stop for festivals. Step back in time and enjoy a slower pace here at the farm. Great view from the front porch. The home is vintage in layout and simplicity. It has the original farmhouse kitchen. Train lovers will enjoy watching the train go by! Please see additional info in details & pictures.

Rapid Creek Retreat
High above the town of Palisade, nestled in the foothills of the Grand Mesa, is the Rapid Creek Retreat. Surrounded by untouched public land you will experience the true gift and grit of Colorado. Enjoy views of the big sky from sunrise to sunset and beyond for magical star gazing. We planned for this home to be ours, every detail of this home was built with intent and love. The feeling here is truly special. For those ‘rough around the edges. Sincerely, The Busch’s
Popular amenities for house rentals in Mesa County
House rentals with a pool

Peach Pad! hot or cool tub 2 bedrooms 2 bathrooms

The Grant House

Relaxing family getaway

Private Pool + Stunning Views | 3BR/3.5BA

Pool, hot tub, views and close to everything

Corner View @ Palisade Legends

Farmhouse Basement Apartment

Palisade Peach Orchard Farmhouse w/Pool & Spa 18+
Weekly house rentals

Fabulous Farmhouse-LARGE HOUSE-perfect for groups!

The Wandering Nomad

4 beds-hot tub-yard&AirConditioning! NO XTRA FEES!

Walkable Downtown Historic Home: A/C, Patios, BBQ

Highline House located near bike trails & the lake

Jewel of Pitkin Mesa

The Orchard House

Gunnison Bungalow
Private house rentals

Cozy 3 bedroom Home. Close to it all!

Colorado river lake house animal sanctuary

Needle Rock View Retreat

1910 Reinvented

Cozy cabin, near biking trails & pet friendly

Midtown Haven - Minutes to Hike, Bike, Wine & Shop

Near downtown/Hiking/Biking, Lakes / river

Family friendly, quiet & comfy 3BR home North area
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