
House holiday rentals in Los Santos Province
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Top-rated house rentals in Los Santos Province
Guests agree: these houses are highly rated for location, cleanliness and more.

Casa Ola – Tropical Beachside Escape
Just a 2-minute walk from Playa Venao’s magical beach and top surf spots, Casa Ola is your own tropical hideaway. This modern, stylish home blends lush nature with laid-back comfort. Inside, you’ll find two cozy bedrooms, a fully equipped kitchen, and a relaxed living area with smart TV. Step outside to your private pool, tropical garden, and BBQ – perfect for sunny days and breezy evenings. Playa Venao’s best restaurants, surf schools, and ocean views are just a short stroll along the sand.

3 min to Pedasi, 5 min to the Beach, Private Pool!
Your family will be close to everything when you stay at this centrally-located place. Outfitted with room to sleep 6 and a fenced yard for your dog, Casa Catch and Relax has it all! Look us up online, Casa Catch and Relax You'll Love - Beach access a short drive or walk away (3 min drive, 10 min walk) - Central to town and local restaurants - Private, fenced outdoor space with pool - Cool days and nights with A/C in every room - Fully equipped kitchen and tons of sleeping space - Wifi

Beachfront Gem w/ Ocean Views & Prime Surf Access
Welcome to your slice of beachfront paradise! Our home sits right on Cambutal's beautiful shoreline. Gorgeous ocean views greet you from every window, while the gentle rhythm of waves creates the perfect soundtrack for your stay. We've equipped the house with Starlink WiFi and a large dining table that doubles as an ideal workspace, making this a perfect retreat for both vacationers and remote workers. The house feels like a real home – comfortable, clean, and ready for your beach memories.

Jungle Tiny House w/ Oceanview – Playa Venao
Live Tiny. Connect Big. Welcome to Tiny Samambaia — a modern tiny house located in Playa Venao, just 5 minutes from the beach. Enjoy ocean views, a fully equipped kitchen, a romantic outdoor hot tub, and the sounds of birds and monkeys in the surrounding jungle. Sustainably built is the perfect escape for surfing, relaxing, or remote work w' reliable Starlink Wi-Fi. Note: Occasional power outages may occur due to the remote location. No generator is available. Thank you for understanding.

Yellowfin Casa 3
New townhouse in Pedasi, on a side street near town and beach. Five minute walk to the town square, 2.2 km walk or drive to Playa Toro. 30 minutes to Playa Venao. Gated courtyard with private pool and outdoor shower. 2 parking spaces in front. Two bedrooms, each with private spacious bathroom. Comfortably furnished. Fully equipped kitchen with dishwasher, refrigerator, gas stove with range hood, coffee maker. Ceiling fan in every room, air conditioning throughout. Smart TV with soundbar.

2 Bed/2 Bath Beachfront House in prime location
Welcome to Casa Marea! We invite you to relax with the whole family at our beautiful beachfront house. The location can’t be beat. Our spacious 2 bed/2 bath house is located on Playa Cambutal, with easy access to the surf break, fishing, and snorkeling right out front. The house is walking distance to restaurants, hotels, and the Local Market. Enjoy a relaxing night's sleep with AC and fans in the bedrooms and the sounds of the ocean in the background. We welcome you to beautiful Cambutal!

Country House Like in the City / La Casita
Casa fresca, con árboles y naturaleza. Áreas amplias para descansar. Ubicación céntrica, cerca de malls, restaurantes, estación de buses y ciclovía. Entrada privada, estacionamientos, cocina completa, mobiliario completo, baño, TV HD con cable, AC en recámara, agua caliente y Wi-Fi. ENG, PORT, FRAN and ITA Spoken! Ahora, Chitré, tiene un problema con el agua: no está potable; tenemos 50% de lo habitual, a veces estamos sin agua por algunas horas. Por favor, consulten antes de reserar.

Pedasí, Los Destiladeros Beach / Casa Serena
❤ Welcome to Casa Serena, escape to our stunning 3-bedroom ocean view house, perfectly located in Playa Los Destiladeros, an area of beautiful beaches in Pedasí. This unique retreat offers a blend of modern luxury and coastal charm, ensuring an unforgettable vacation experience for you and your loved ones. Book your stay today and experience the magic of Casa Serena. Create lasting memories with your family and friends in this perfect ocean view escape.

Casa Pelicano - Tropical house w pool and seaview
Welcome to Casa Pelicano! Indulge yourself in a retreat with breathtaking views of the ocean and mountains from every corner. Unwind in the private refreshing pool, where the turquoise waters seem to blend seamlessly with the horizon. The stylish interior features open-plan living spaces, perfect for entertaining or relaxing. Whether you're soaking up the sun or gazing at the moonlit ocean under the stars, this home is your ultimate escape.

Villa La Jungla featuring a New Pool
Escape to this serene, private retreat just minutes from Pedasí, Playa Venao, and stunning beaches. Perfect for 4–8 guests, the home features spacious en-suite bedrooms with quality linens, a fully equipped kitchen, and a newly resurfaced infinity pool. Enjoy total privacy, comfort, and easy access to local adventures. Whether you're here to surf, explore, or relax, this is your ideal home base for a peaceful and memorable stay.

A minimalist Casita in Pedasi
Imagine a peaceful casita with ocean views and a nearby pool house boasting an edgeless pool overlooking the ocean. Plus, you have your own private beach. Inside, you will find an open-concept living space adorned with simple yet stylish furnishings, designed for relaxation and comfort. It's the perfect blend of tranquility, peaceful seclusion and breathtaking natural beauty. Gated community, 24 hour security

Beach side stay at Casa Blanca
This beautiful two bedroom, double-storey house sits in one of the best locations around, nestled amongst the trees and overlooking a stunning swimming bay in the tropical paradise of Cambutal. Perfectly situated, you will have the warm Pacific Ocean literally on your doorstep, as well as easy access to the highlights of a beach holiday - surfing, swimming, sunsets and more.
Popular amenities for house rentals in Los Santos Province
House rentals with a pool

A Good Walk-Pedasi

Tropical Townhouse Living

2/2 Private Oasis Pedasi's best location & rental!

Nearly Oceanfront: Blue 3 Bedroom Spacious Villa

NINA HOUSE, a spacious and cool house in Chitré.

Casa Magna - Casa Completa

Casa Del Amor in Pedasi, Panama Oceanfront paradise

Casa - Domaine De La Rose
Weekly house rentals

Ocean View, Ocean View El Ciruelo

Excellent for Festivities

Our Happy Place

La Hacienda Ojo de Agua * Family & Friends Getaway

Entire house in Herrera

Peaceful Pedasi

Casa Iguana 3 -Sleep 4-queen bed & 1 bunk bed

Tropical Oasis, Full House, Private Pool,
Private house rentals

Casa Las Tablas

Las Casa De Abuelita

Las Tablas Comfy and Spacious Private Room

Minimalist House In Chitre

Windward View of the Pacific

Villa Del Mar - Blue Venao 3 BR

Casa Gerard

Chitré: Weliss's House
Destinations to explore
- Rentals with outdoor seating Los Santos Province
- Pet-friendly rentals Los Santos Province
- Smoking-friendly rentals Los Santos Province
- Apartment rentals Los Santos Province
- Hotel rentals Los Santos Province
- Rentals with a hot tub Los Santos Province
- Waterfront rentals Los Santos Province
- Bed and breakfasts Los Santos Province
- Beachfront rentals Los Santos Province
- Family-friendly rentals Los Santos Province
- Rentals with a patio Los Santos Province
- Rentals with a firepit Los Santos Province
- Rentals with an accessible-height bed Los Santos Province
- Flat rentals Los Santos Province
- Rentals with pools Los Santos Province
- Rentals with a washing machine and dryer Los Santos Province
- Guest house rentals Los Santos Province
- Rentals with beach access Los Santos Province
- Villa rentals Los Santos Province
- House rentals Panama