
Guest house holiday rentals in South Carolina
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Top-rated guest house rentals in South Carolina
Guests agree: these guest house rentals are highly rated for location, cleanliness and more.
Holiday rentals for every style
Get the amount of space that is right for you
Popular amenities for guest house rentals in South Carolina
Family-friendly guest house rentals

Charleston's Coolest Neighborhood

Bungalow Under The Oaks

Executive Suite on a farm @GSP Airport

Cozy Park Circle, Charleston Guest House

Spacious Daniel Island Apartment

Mother in Law in James Island Riverland Terrace

Mountain Edge Loft

5 STAR 1bd/1ba Shem Creek Retreat in #1 MtP area!
Guest house rentals with a patio

Quaint Cottage Studio in Ashley Forest (Avondale).

Bungalow on a 3 acre mini farm

Modern guesthouse in downtown TR

Foothills Favorite

Driftwood Cottage

Finished Room over Garage (FROG) on Reedy River

Aiken Barndominium/Studio Apt

Cozy Cottage! 5 mins from Kiawah!
Guest house rentals with a washing machine and dryer

Amazing Studio Guesthouse in COLA suburb.

Beach, downtown, Alhambra Hall weddings so close!

Camden Coach House Long term stay southern balance

The Guest House By The River

Camper at Hickory Lodge and Guesthouse

James Island "La Casita" Nestled btw Beach & City

Summerville’s Tiny Oak Hideaway

Lit'l Bit O' Heaven- Rocky Top Lodge
Destinations to explore
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