Holiday rentals in Santa Clara, Panama City

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Santa Clara, Panama City

Guests agree: these stays are highly rated for location, cleanliness and more.

%{current} / %{total}1 / 1

Guest favourite

A comfortable sleeping area is presented with a spacious bed covered in a soft, patterned blanket. Lively artwork featuring tulips adorns the wall above, while bedside tables with lamps provide gentle illumination. Dark curtains frame the window, and air conditioning is installed overhead.

Loft in Panama

4.94 out of 5 average rating, 51 reviews

Modern apartment 20 minutes from the airport

Comfortable and cozy apartment on Av. la Pulida, 8 minutes from the Cincuentenario metro station. For business travelers and couples, this apartment features a bedroom with a full bed, a TV in the room, a full bathroom with hot water, a fully equipped kitchen, a living-dining room, a Smart TV, air conditioning, a laundry room, and a closet. It's just 8 minutes from the metro station and offers easy access to any point in the city. Centrally located, yet quiet. Enjoy a perfect stay!

Superhost

A panoramic view of the Panama City skyline is displayed, showcasing a lively urban landscape at dusk. The dark water reflects city lights, while notable icons for air conditioning, kitchen amenities, and WiFi are presented prominently, representing essential features of the accommodation.

Flat in Panamá

4.93 out of 5 average rating, 27 reviews

Cozy Apt+WiFi+Kitchen+AC+Laundry+TV+Parking@Panamá

✔️ SuperAnfitrión Verificado ¡Tu estadía estará en las mejores manos! Apartamento en Panamá, Panamá 📍Excelente ubicación 🏡 Espacio limpio, cómodo y seguro. 💬 Estoy disponible para ayudarte durante toda tu estancia. 🔑 ¡Reserva hoy y siéntete como en casa en Panamá! 👨‍👧‍👧 Ideal para todo tipo de turista El apartamento ofrece: 🌐 Wifi 📺 TV 🍳 Cocina 💻Zona de trabajo 🌬️Aire acondicionado 🚗Estacionamiento 🌸Lavadora 🧖‍♂️🧖‍♀️ducha con agua caliente

Guest favourite

Flat in Panamá

4.95 out of 5 average rating, 19 reviews

Amazing Apt. Close to the City

Your family will be close to everything when you stay at this centrally-located place. This Apartment has 2 bedrooms and 2 full baths. Both bedrooms are equipped with Queen size beds. It has a swimming pool, sport court, gym and play area for kids. Centrally located to all restaurants, shopping and major freeways. Just 25 minutes away from Tocumen International Airport and Panama City. This apartment is great for family or business.

Guest favourite

A view is captured from a dining area featuring a textured table setting with a glass placed on it. In the background, a spacious living room is visible with large windows allowing natural light to enhance the neutral tones of the furnishings.

Flat in Costa del Este

5 out of 5 average rating, 17 reviews

Luxury Apartment in Panama | 2BR + Views + Pool

Live a Luxury Experience in the Heart of Panama City 🏙️✨ Welcome to your home away from home: a modern and elegant apartment designed to offer you the highest level of comfort, style, and functionality. Perfect for tourists, business travelers, or remote workers, every space has been thoughtfully designed to ensure an unforgettable stay. We look forward to welcoming you and offering you a luxurious and comfortable experience.

Guest favourite

A compact studio showcases a spacious bed with light bedding set against a soothing teal backdrop. A small dining table and a shelving unit are visible, enhancing the functional layout. Natural light enters through the window, highlighting a cozy and organized atmosphere.

Guest house in Panama City

4.89 out of 5 average rating, 228 reviews

Boho Studio-Private Terrace near the airport

Perfecto para 1–2 huéspedes, Wifi Terraza tranquila, room independiente, cuenta con A/C , y su baño pequeño. Ubicado cerca del Aeropuerto Internacional de Tocumen, de 10 a 13 minutos en auto. El Studio está Cerca de 2 Centros Comerciales, Metromall y Los Pueblos. La zona residencial es segura al caminar, calles organizadas y limpias. Tenemos la estación del Metro de Cerro Viento afuera en Metromall.

Guest favourite

The living area features a light blue accent wall and a cozy gray sectional sofa accompanied by a round ottoman. A large window with striped awnings allows natural light to fill the space. Wall art and a small shelf with a clock add functional decor.

Flat in Distrito de Panamá

4.76 out of 5 average rating, 17 reviews

Hippodrome Suites

Hippodrome Suites is located in a safe gated community in the suburbs of Panama City, just a short drive 🚘 from the Tocumen International Airport (✈️PTY), Santa Maria and Costa del Este Budiness District. City views, 24-hours security and covered parking. It is ideal for resting and working, business trips or layover nights. This condo offers a perfect mix of comfort, convenience, and tranquility.

Top guest favourite

The kitchen area features a black dining table with four chairs, complementing a modern microwave and refrigerator. Warm decorative elements, including wall art and a candle, add character to the space, which is equipped with essential appliances and a clean countertop.

Home in Panamá

4.94 out of 5 average rating, 389 reviews

Private Studio 10 Min from the Airport!

Entire apartment 10 minutes from the airport! The apartment is fully furnished including appliances and kitchen items, toiletries, dining room, work table and more. Just a few minutes walk from the SAN ANTONIO METRO Station, restaurants, shopping malls, laundries, supermarkets and pharmacies. We offer tours to San Blas to make the most of your trip. Our house is your house in Panama 🇵🇦

Top guest favourite

A spacious living area is highlighted by large windows that offer views of urban high-rises and the distant ocean. A soft, rounded sectional sofa and a plush armchair provide comfort, while a dark area rug anchors the space beneath a sleek coffee table.

Flat in Costa del Este

5 out of 5 average rating, 20 reviews

Elegant Apt in Costa del Este. Premium Amenities

Enjoy a luxurious stay in our modern design apartment located in the exclusive Costa del Este area. It has a room with a private bathroom, a cozy living room, and a fully-equipped kitchen. Building facilities include a state-of-the-art gym, swimming pool, and co-working space ideal for remote work. Perfect for extended stays, combining comfort and convenience in the heart of Panama.

Guest favourite

The open living area showcases a modern design, with a comfortable sofa facing a large window draped in sheer curtains. A dining table is positioned near the kitchen, featuring sleek appliances and stylish seating. The bedroom area is seen in the background, characterized by a spacious layout.

Apartment in Costa del Este

5 out of 5 average rating, 7 reviews

Studio Nestled by the Park in Costa del Este

Your home away from home is at PH Arcadia del Este. Apartments of 76m2, provides a cozy and comfortable atmosphere. 🍳It has 1 spacious and equipped kitchen to prepare your best dishes. 🛀2 bathrooms with shower. 📺1 comfortable and spacious TV room. 🛏️1 bed Incredible views from our social areas of the city and the connection of the river with the sea.

Guest favourite

A modern living room is depicted, featuring a wall-mounted television above a black media console. Two light-colored armchairs are positioned beside a round coffee table, which is adorned with decorative items. A large window allows natural light and offers views of the surrounding area.

Flat in Costa del Este

5 out of 5 average rating, 6 reviews

1bd/2Bthrm East Coast-Panama

What do you expect to know and enjoy Panama? Stay in our modern, furnished and quiet apartment in Costa del Este, where you can enjoy a spectacular view, fast Wi-Fi, fully equipped kitchen, top floor pool access with city view and an incredible sunset, gym and more. Surrounded by cafes, parks and everything you need to have the best experience in the city.

Superhost

A well-appointed bedroom features a spacious bed with a decorative grey and white bedspread. A framed artwork of leaves adorns the wall above, and soft brown curtains frame a window. A small table with a lamp is positioned next to the bed, enhancing functionality.

Guest house in Panama City

4.81 out of 5 average rating, 79 reviews

A small apartment-style annex

The place is close to Tocumen airport (15 minutes), has WiFi, cable service, Netflix and has shops and supermarkets around it, very close to nature, it is a quiet and cozy place. You can also take a taxi or Uber to get to the Panama Metro (10 minutes). We have round-trip transportation service to Tocumen Airport, for an additional cost.

Guest favourite

A spacious bedroom is presented with floor-to-ceiling windows offering stunning city views. The bed features a plush, textured blanket, and a large flat-screen TV is mounted on the wall. The polished floor reflects the natural light streaming in, enhancing the airy ambiance.

Flat in Costa del Este

4.94 out of 5 average rating, 53 reviews

Penthouse with Panoramic View and Luxury Amenities

Amazing spacious Penthouse with the best view in all of the East Coast, finely furnished with materials of excellent quality. You will be hosted in one of the best areas (top 5 in the ranking) of places to live in Latin America.