Some info has been automatically translated. Show original language

Holiday rentals in Isthmus of Panama

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Isthmus of Panama

Guests agree: these stays are highly rated for location, cleanliness and more.

%{current} / %{total}1 / 1
Top guest favourite
Two rustic-style cabins are set along the shoreline, surrounded by lush tropical trees. A wide patio is furnished with colorful chairs, offering views of the water. The natural beauty of the landscape is complemented by the tranquil waves gently lapping at the shore.
Home in La Guaira
4.97 out of 5 average rating, 105 reviews

Puntita Manzanillo, fantastic sea and jungle

Come visit one of the most unique and exclusive properties in the Panamanian Caribbean. A magical completely private 5 acre property nestled between the Caribbean Sea (500meters of ocean front) and the jungle. Surrounded by a garden of corals and visited by monkeys and macaws. Our energy is solar and we have our own aqueduct. Temperature oscillates between 72 and 84 degrees F. It is rented in its entirety. It has 3 one bedroom cabins with full baths. Satellite Internet (Starlink) is provided.

Top guest favourite
An aerial view of the property showcases a spacious layout surrounded by lush greenery. A large saltwater pool and a hot tub are visible alongside a well-maintained outdoor area with red umbrellas providing shade. The roof of the main structure features a brown tone, blending with the natural surroundings.
Home in Costa Esmeralda
4.98 out of 5 average rating, 190 reviews

Beach House-Amazing Pool & Jacuzzi - Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with Smart Home Energy Management Systems.

Guest favourite
An aerial view captures the layout of Tubasenik, showcasing a triangular island adorned with numerous palm trees and traditional cabins. A sandy beach gently curves around the island's edge, while boats are visible along the shoreline, complementing the clear turquoise waters surrounding the paradise.
Hut in San Blas Islands
4.91 out of 5 average rating, 118 reviews

San Blas islands, Tubasenik cultural getaway

Immerse yourself in the stunning beauty of Guna Yala, a paradise of crystal-clear waters and white-sand beaches. Explore secluded islands, relax under swaying palms, or snorkel vibrant coral reefs teeming with marine life. This experience goes beyond typical tourism—it’s a journey into the heart of the Guna culture, an indigenous community that cherishes its ancient traditions and deep connection to nature. Discover exclusive gems of the archipelago and make your adventure truly unforgettable

Guest favourite
Home in Playa Venao
5 out of 5 average rating, 5 reviews

Jungle Tiny House w/ Oceanview – Playa Venao

Live Tiny. Connect Big. Welcome to Tiny Samambaia — a modern tiny house located in Playa Venao, just 5 minutes from the beach. Enjoy ocean views, a fully equipped kitchen, a romantic outdoor hot tub, and the sounds of birds and monkeys in the surrounding jungle. Sustainably built is the perfect escape for surfing, relaxing, or remote work w' reliable Starlink Wi-Fi. Note: Occasional power outages may occur due to the remote location. No generator is available. Thank you for understanding.

Top guest favourite
Lush tropical gardens filled with vibrant flowers lead towards a traditional structure. The backdrop features rolling mountains, partially shrouded in greenery, under a clear blue sky. A variety of plants create a peaceful natural setting, inviting exploration and observation.
Farm stay in Boquete
4.92 out of 5 average rating, 289 reviews

Casitas in Butterfly and Honey Farm

Romantic setting, immersed in nature and yet close to town. Fibre Optic Internet. Nestled in extensive tropical gardens on a traditional Boquete Coffee Estate. Abundance of birds, feeders and native bee hives. We are home to Panamas largest butterfly exhibit and specialty honey company. We offer a hearty breakfast. We can accommodate 4 px but booking price including breakfast is for 2px. We charge an additional $15 per person over 12 yrs, an additional $10 for children under 12 yrs

Guest favourite
The image features a stylish outdoor pool surrounded by lounge chairs, with elegant statues and lush greenery nearby. A distinctive tower, known as the Tornillo, rises majestically against a twilight sky, highlighting the modern architecture of the surrounding buildings.
Apartment in Panamá
5 out of 5 average rating, 13 reviews

UrbanLuxuryintheCloudsFreeParkingclosetoeverything

Perched high above the city, this refined apartment offers a perfect blend of modern comfort and elevated style. Sunlight pours through expansive windows, revealing sweeping skyline views that feel both energizing and serene. The open living space is thoughtfully designed with clean lines, premium finishes, and a warm, inviting atmosphere ideal for relaxing or entertaining. As day turns to night, the city lights create a stunning backdrop, making this apartment a true urban retreat

Guest favourite
A scenic view of rolling hills under a colorful sky at sunset. Shades of orange, pink, and purple blend, creating a vibrant horizon. Lush trees are scattered across the landscape, adding a touch of greenery to the terrain.
Cottage in Olá
4.95 out of 5 average rating, 19 reviews

Country House in Olá, rivers, waterfalls, Los Picachos

Finca La Terapia lives up to its name, nestled in the mountains of the picturesque village of Olá de Penonomé, where you can disconnect from the busy day-to-day life of the city. It has 42 private hectares to explore nature. The district of Olá is characterised by the most beautiful natural landscapes, among which we can mention, Los Chorros de Olá, Chorros las Mesitas, Cerros los Picachos, Rio San Antonio, Balneario Brujas, among others, just a few minutes from the Finca.

Guest favourite
An inviting outdoor pool area is surrounded by lush greenery and vibrant flowers. Comfortable lounge chairs are positioned nearby. The expansive view captures a tranquil lake and well-maintained landscaping under a bright sky, providing a serene outdoor retreat.
Home in Rio Hato
5 out of 5 average rating, 5 reviews

Private Pool/Buenaventura/Beach access/750MB

Spacious house located in Buenaventura. This high-end location features: - A Marina where you can load and unload your water toys! (at an extra cost) - Amazing restaurants where you can enjoy different flavors from around the world. - A fully stocked wine store where you will find a varied selection, as well as charcuterie and a excellent bread. - There are yoga and pilates classes - Social areas and beach access - A 19-hole golf course. - An amazing coffee store.

Guest favourite
The exterior of Casa Serena showcases a spacious two-story structure with a warm, inviting facade featuring wooden accents. A wooden deck surrounds a private pool, and comfortable lounge chairs are positioned beside it. Umbrellas provide shade, while lush greenery complements the peaceful setting.
Home in Playa Los Destiladeros
5 out of 5 average rating, 13 reviews

Pedasí, Los Destiladeros Beach / Casa Serena

❤ Welcome to Casa Serena, escape to our stunning 3-bedroom ocean view house, perfectly located in Playa Los Destiladeros, an area of ​​beautiful beaches in Pedasí. This unique retreat offers a blend of modern luxury and coastal charm, ensuring an unforgettable vacation experience for you and your loved ones. Book your stay today and experience the magic of Casa Serena. Create lasting memories with your family and friends in this perfect ocean view escape.

Top guest favourite
A spacious outdoor deck features modern furniture arranged for relaxation, overlooking a lush mountainous landscape. Verdant hills and a colorful sky at dawn create a tranquil environment, inviting guests to enjoy the natural beauty and serenity of the surroundings.
Villa in El Copé
4.92 out of 5 average rating, 183 reviews

Mountain retreat

Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.

Top guest favourite
An aerial view captures the lush greenery surrounding the treehouse, which extends over tranquil waters. The vibrant blue and green hues of the lagoon contrast with the shoreline, showcasing the natural beauty of the area. Mangroves frame the water's edge, emphasizing the secluded environment.
Treehouse in Provincia de Bocas del Toro
4.93 out of 5 average rating, 237 reviews

Cocovivo Mangrove Treehouse

This secluded loft-style treehouse sits on stilts above the water, 30 feet from our colorful coral reef. Transparent and airy but bug proof walls let you enjoy the fresh ocean breeze and views while keeping you safe and cozy. When a sloth comes to visit, no need to leave the house to see him! Blend in with the surroundings of mangrove, lagoon and jungle, and enjoy water and reef access from your own deck. Bright and airy, 100% eco-conscious.

Top guest favourite
Cabin in Jaramillo
5 out of 5 average rating, 11 reviews

Coffee Cabins - Cabin 2

Welcome to the Coffee Cabins. This is one of four stunning A-frame cabins perched on the side of a mountain in the middle of a coffee field. You’re literally surrounded by coffee, both on the trees and in your kitchen with the complimentary coffee grown right here on the farm. Enjoy larger than life views to both the north towards the continental divide and to the west framing Volcan Baru, Panama’s highest peak.

Popular amenities for Isthmus of Panama holiday rentals