
Hotel holiday rentals in Downtown
Find and book unique hotel rentals on Airbnb
Top-rated hotel rentals in Downtown
Guests agree: these hotel rentals are highly rated for location, cleanliness and more.
Holiday rentals for every style
Get the amount of space that is right for you
Popular amenities for hotel rentals in Downtown
Family-friendly hotel rentals

Stylish San Diego downtown Suite

Relax and Recharge! Pool, Beach Access, Parking!

Stylish South Bay Home

Budget-Friendly Stay w/ Easy Access to SeaWorld

Pet-friendly Hotel with Free Breakfast and Pool!

Stay Near Top Attractions | Balcony & Pet-Friendly

MCRD Grad Hotel Room - Breakfast

Family Vacation! Close to SeaWorld! Onsite Pool!
Hotel rentals with a pool

1-Bedroom Hotel Suite - 2 beds

Recently reno’d escape near the Gaslamp Quarter

Iconic Resort in San Diego

Beachside La Jolla Stay | 1 Unit | Near Shores

Playful escape near games & concerts at Petco Park

Free B’fast & Parking – Minutes to Pacific Beach

Downtown Delight: Pets Allowed, Parking, Pool!

Comic-Con 2026 in San Diego @ Marriott Pulse Suite
Hotel rentals with a patio

Modern King Room | Luxe Stay in Little Italy

Club Wyndham Harbour Lights

Comic-Con 2026: Spacious King Suite + Sofa Bed

ITH Mission Beach Backpacker Hostel Mixed Dorm

2 bd/2 bth Resort Style Hotel

Nice Property, stay right in SD!

Worldmark Studio Sleeps 4

WorldMark San Diego Mission Valley Two Bedroom
Quick stats about hotel rentals in Downtown
Total rentals
260 properties
Nightly prices starting at
€ 34 before taxes and fees
Total number of reviews
4.2K reviews
Family-friendly rentals
60 properties are a good fit for families
Pet-friendly rentals
90 properties allow pets
Rentals with a pool
160 properties have a pool
Destinations to explore
- Family-friendly rentals Downtown San Diego
- Fitness-friendly rentals Downtown San Diego
- Townhouse rentals Downtown San Diego
- Rentals with a fireplace Downtown San Diego
- Rentals with breakfast Downtown San Diego
- Apartment rentals Downtown San Diego
- Rentals with beach access Downtown San Diego
- Waterfront rentals Downtown San Diego
- Rentals with an EV charger Downtown San Diego
- Rentals with pools Downtown San Diego
- Smoking-friendly rentals Downtown San Diego
- Rentals with a sauna Downtown San Diego
- House rentals Downtown San Diego
- Flat rentals Downtown San Diego
- Loft rentals Downtown San Diego
- Rentals with a patio Downtown San Diego
- Hostel rentals Downtown San Diego
- Rentals with a cinema Downtown San Diego
- Rentals with a firepit Downtown San Diego
- Rentals with a hot tub Downtown San Diego
- Serviced apartment rentals Downtown San Diego
- Rentals with a beach view Downtown San Diego
- Rentals with a washing machine and dryer Downtown San Diego
- Pet-friendly rentals Downtown San Diego
- Rentals with outdoor seating Downtown San Diego
- Hotel rentals San Diego
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- Rosarito Beach
- Oceanside City Beach
- Torrey Pines State Beach
- Pacific Beach
- Tijuana Beach
- SeaWorld San Diego
- Coronado Beach
- University of California San Diego
- LEGOLAND California
- San Diego Zoo Safari Park
- Balboa Park
- La Misión Beach
- Oceanside Harbor
- Coronado Shores Beach
- Black's Beach
- Belmont Park
- Moonlight Beach
- Sesame Place San Diego
- Liberty Station
- Law Street Beach
- Torrey Pines Golf Course
- Santa Monica Beach
- USS Midway Museum
- Mission Beach