
Holiday rentals in Santa Cruz County
Find and book unique accommodation on Airbnb
Top-rated holiday rentals in Santa Cruz County
Guests agree: these stays are highly rated for location, cleanliness and more.

Javelina Corner
Our place is close to Patagonia Lake, 10 minute drive, Patton's hummingbird center, 2 minute drive or 8 minute walk. There is access to the Arizona trail at two locations within 10-20 minute drive and numerous other hikes! Tombstone, Bisbee, The Art haven of Tubac is close by and Nogales Mexico is 19 miles. You’ll love our place because of the neighborhood, the coziness, and the comfy beds. Our place is good for couples, solo adventurers, business travelers, families , and furry friends (pets).
4.84 out of 5 average rating, 148 reviews
Serenity, Starlink and waking up with bird songs
Wake up to nothing but bird sounds, enjoy morning coffee and the bright stars in dark nights on the covered patio. Contemporary furnished, spacious guest house with beautiful Mountain Views, in rural location, but close vicinity to the towns of Patagonia and Sonoita. Open kitchen - dining area floor plan. The house is set up with all amenities needed by seasonal visitors and remote working professionals. No pets. A small dog may be ok. 1 month or longer preferred. Shorter stays on request.
5.0 out of 5 average rating, 42 reviews
A Tubac Getaway
Amazing luxury vacation rental in beautiful, historic Tubac, Arizona. Located in The Sanctuary neighborhood, this home is within walking distance of either The Village of Tubac or the Tubac Golf Resort. Plenty of nearby activities including hiking, golf, birdwatching, or day trips to southern Arizona. Visit unique shops in The Village of Tubac or the Resort for furnishings, jewelry, or great food at a variety of restaurants. Come see everything that southern Arizona has to offer!
5.0 out of 5 average rating, 143 reviews
Patagonia Lake Hideaway
PRIVATE SPACE! $105 p nite NO CLEANING FEES but airbnb charges its own fees. king bed, picture window, sofa, french doors,electric fireplace, tv, Private courtyard&patio, sunrise over Patagonias,sunset behind the Atascosas. Birding paradise.part of Madrean sky Island.Lake minutes away with boat rentals, swimming, fishing, hiking, small beach. Easy travel toTombstone, AZ Trail, Tubac, Kartchner caverns, Patagonia, Mexico, wine and spirit tasting .check in whenever.check out 5pm
4.94 out of 5 average rating, 153 reviews
Kestrel Cottage at Birdsong Retreat
ATTENTION SUMMER BOOKINGS: Swamp cooler entire cottage and AC wall unit in queen bedroom. We provide fans. With monsoon rains, it’s too humid to use swamp cooler. Cottage priced to reflect the heat. Escape to serene high desert grasslands in Patagonia, AZ, offering 360-degree views at 4,058 feet offering respite from the Phoenix and Tucson heat. Nestled within BirdSong Retreat on 37 acres, the Kestrel Cottage promises luxurious accommodations and a focus on well-being.
4.97 out of 5 average rating, 132 reviews
Mesquite Haven
Fantastic home located in a peaceful and beautiful community surrounded by desert nature. This Santa Fe style residence invites you to relax and escape a busy lifestyle while still having access to modern amenities. Enjoy life outdoors in a basically traffic free private community rich with local flora and fauna. The location is great for morning or evening walks or runs, Tubac Resort wedding guests, visits to the village, hiking trips, etc.
5.0 out of 5 average rating, 22 reviews
Cozy Rio Rico guesthouse with a view
This spacious guesthouse is in an ideal rural setting. Located near the Mexican border, the art community at Tubac, and the old Spanish mission of Tumacacori, there is lots to see and do. (Not to mention many good golf courses.) I am looking forward to your visit! To make your stay both pleasant and sanitary I steam clean floors, sani-wash all linens and towels, and wipe counters, sinks and toilet with sanitizer spray. Rest easy here!
4.87 out of 5 average rating, 380 reviews
Under the Oaks
Escape to the peaceful beauty of Under the Oaks, nestled beneath three magnificent oak trees with sweeping views of rolling grasslands and distant mountains. Relax in the spotless, comfortable home, unwind on the screened porch as the sun sets, or enjoy birdwatching, grilling, and a glass of local wine beneath the spacious ramada. Shady oaks, abundant wildlife, and tranquil surroundings create the perfect Southern Arizona getaway.
4.96 out of 5 average rating, 226 reviews
Sky Island Retreat Sonoita, AZ.
Sky Island Retreat is a quiet and peaceful hilltop retreat in which you can relax and enjoy the natural beauty of this historic area. The casita is the original but updated ranch house built in the late 60’s. We have kept much of its original charm while upgrading to modern comfort and conveniences. We are located on a privately gated property just minutes from the heart of Sonoita and Southern AZ’s growing wine country.
4.98 out of 5 average rating, 291 reviews
Fully private casita in heart of town!
This popular 1-bedroom guest house in the heart of the village offers a comfortable and fully private space that is bright, thoughtfully decorated, and full of authentic Patagonia charm. Walkable to all of Patagonia's restaurants, shops, and birding and hiking trails, and only a 15 minute drive to Patagonia Lake, or a 20 minute drive to nearby wineries. This casita is the perfect home base for your Patagonia adventures!
4.94 out of 5 average rating, 33 reviews
Views
Forget your worries in this spacious and serene space. It is fully stocked and has all the tools to cook a meal or sip wine next to the fire pit. The house is at the end of the road and the views are one in a million. Relax next to the fireplace, enjoy the views, watch a movie, or browse the internet in the comfortable living room. This house has everything you need for a relaxing getaway.
4.96 out of 5 average rating, 50 reviews
Poolside Escape Near Patagonia
Unwind at this scenic hilltop retreat just a mile south of Patagonia, AZ. Enjoy a private pool with stunning Red Mountain views, 3 spacious bedrooms, and a dedicated office space. Close to hiking, biking, and town. Relax in modern comfort, soak up breathtaking sunsets, and explore the best of Southern Arizona. Pet-friendly for making memories with the whole family!
4.95 out of 5 average rating, 74 reviewsPopular amenities for Santa Cruz County holiday rentals
Other great holiday rentals in Santa Cruz County

New Haven on Sonita Creek
4.9 out of 5 average rating, 31 reviews
Xanadu DREAM LAND Casita Private Guest house King
4.94 out of 5 average rating, 51 reviews
Camp Cathy
5.0 out of 5 average rating, 16 reviews
Blue Bunkhouse @ RockRoseRanch | Dog Friendly
5.0 out of 5 average rating, 63 reviews
2 min to wineries | 2.75 acres | Kings | PetsOK
5.0 out of 5 average rating, 72 reviews
Desert Oasis Retreat
4.9 out of 5 average rating, 10 reviews
Rojo Grande Ranch
4.98 out of 5 average rating, 47 reviews
Mountain View Ranch Arizona
5.0 out of 5 average rating, 18 reviewsDestinations to explore
- University of Arizona
- University of Arizona
- Saguaro National Park
- Tucson Convention Center
- Arizona-Sonora Desert Museum
- Tumamoc Hill
- Patagonia Lake State Park
- Kartchner Caverns State Park
- Sabino Canyon Recreation Area
- Titan Missile Museum
- Tucson Botanical Gardens
- Reid Park Zoo
- Tucson Museum of Art
- Rialto Theatre
- Pima Air & Space Museum
- Mission San Xavier del Bac
- Tumacacori National Historical Park
- Children's Museum Tucson
- Trail Dust Town
- Sonoita Vineyards
- Mini Time Machine Museum of Miniatures
- Tubac Presidio State Historic Park
- Roy P Drachman - Agua Caliente Regional Park
- Mercado San Agustin





