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Holiday rentals in Panama Canal

Find and book unique accommodation on Airbnb

Top-rated holiday rentals in Panama Canal

Guests agree: these stays are highly rated for location, cleanliness and more.

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Guest favourite
Flat in San Felipe

In the heart of Casco, refurbished and with parking

Escape and discover the old town in this remodeled, comfortable and central accommodation in the heart of Casco Viejo. Our location is the best, it will make you come back. Close to restaurants, bars, impressive churches, and museums. The property dates back to the 17th century (1756) history and good atmosphere. You can explore the area on foot, fully equipped kitchen, European king bed, you will feel right at home, surrounded by the famous calicanto walls. -A large living room -Fully-equiped kitchen

4.96 out of 5 average rating, 263 reviews
Top guest favourite
Apartment in Bella Vista

Modern Stay | Prime Location | Pool, Rooftop & Gym

Enjoy a spacious, modern apartment with a standing balcony offering beautiful city and mountain views, right in vibrant, local Panama City on Calle 50. Prime location near the iconic Tornillo Building. Walk to the Metro, Cinta Costera, Panama Bay, restaurants, bars, coffee shops, local eateries, and supermarkets Enjoy Wi-Fi, Smart TV, parking, pool, gym, workspace, plus an on-site restaurant, coffee shop, and rooftop bar with breathtaking 360° city views Great location & everything close by!

4.98 out of 5 average rating, 109 reviews
Top guest favourite
Place to stay in Panama City

Casa Condal - Your Luxury Retreat in Cerro Azul

Birdwatching • Romantic Getaway • Remote Work Escape the city. Breathe pure mountain air. Reconnect with nature. Casa Condal - private, modern, sustainable and regenerative hospitality inside Chagres National Park WiFi 65" Smart TV. Sound Bar Self check-in Private parking Fully equipped kitchen 220mts. private trail Deck-Mirador + FirePit, panoramic view of the mountains and valley King bed + Full size sofa bed BBQ Wheelchair accessible 40 min from Tocumen Airport. 1 hr from Panama city.

5.0 out of 5 average rating, 28 reviews
Top guest favourite
Flat in Bella Vista

Modern City Escape Nice Views & Great Location!

Modern and stylish apartment with an open layout and all the comforts of home. Sleeps up to four with a Queen bed in the bedroom and a sofa bed in the living area. Enjoy a fully equipped kitchen, high-speed-WiFi and A/C. Located in the heart of the city, just steps from the banking district and Via España, and close to Soho Mall, Multiplaza Mall, restaurants, cafes, pharmacies, and the metro. Perfect for business or leisure travelers seeking convenience, comfort, and a true City experience.

5.0 out of 5 average rating, 37 reviews
Guest favourite
A modern living area is featured, showcasing a large wall-mounted television surrounded by a lighted panel. Seating is provided by a dark sofa with decorative pillows. A round dining table is visible in the foreground, complemented by four black chairs. Tall windows offer city views.
Flat in Panama City

Luxury Oceanfront Resort 22nd Floor View, 200°

Luxury oceanfront apartment on the 22nd floor with breathtaking panoramic views of Panama Bay, the skyline, and historic Casco Antiguo. Located on the famous Cinta Costera, this resort-style apartment offers 2 bedrooms, 2 bathrooms, luxury kitchen, 65” TVs, washer/dryer, and sleeps up to 6 guests. Enjoy spectacular sunsets from the balcony and access to infinity pool, gym, and premium amenities, just minutes from restaurants, nightlife, and Panama City’s top attractions.

4.85 out of 5 average rating, 73 reviews
Guest favourite
Flat in Panama City

Ocean View | Rooftop Pool | Luxury Stay

Wake up to a stunning ocean view right from your window at BrisaMarina. This luxury apartment is located in the spectacular The Sands building, right on the Cinta Costera. The modern and cozy space features bright natural light, air conditioning, high-speed Wi-Fi, and a fully equipped kitchen for your comfort. You’ll be just minutes away from restaurants, beaches, and top attractions. Perfect for couples, business travelers, or weekend getaways.

4.97 out of 5 average rating, 97 reviews
Guest favourite
A spacious living area features light wood flooring and a modern open kitchen. Two light-colored sofas surround a marble coffee table, while a dining area with a stylish table sits nearby. A spiral staircase leads to the upper level, and decorative artwork adorns the walls.
Loft in San Felipe

Loft 3b Old Town Best! It's 150 m2 (492 feet)

Immerse yourself in the historic charm and modern elegance of our 3-bedroom, 150 m2 loft in the heart of the Old Town. With wooden floors that radiate warmth and a modern open-plan kitchen ideal for sharing, this space guarantees a memorable vacation. Located on Avenida A, you'll find yourself just a few steps away from exquisite restaurants, museums, colonial churches, and the Casco's coveted rooftops, making every day an adventure.

4.93 out of 5 average rating, 126 reviews
Guest favourite
An interior view showcases a modern, multi-level loft with a wooden staircase leading to the upper loft area. Soft lighting creates ambient hues throughout the open space, highlighting the kitchen and living areas, where stylish furniture is arranged for comfort. Exposed stone walls add texture.
Loft in Panama City

2B Loft Studio | Design By Paradox

Private 40 m² loft studio in Santa Ana, about a 5-minute walk from Casco Viejo. Loft Studio sleeps up to 3 guests with a Queen bed on a mezzanine and a sofa bed, plus a full kitchen, private bathroom, air conditioning, hot water, fast WiFi, dining space, and a 1.8 m desk. Enjoy a TV with Roku and host-provided Netflix, Disney+, Max, and Prime. Guests have access to the shared balcony, patio, and paid laundry.

4.89 out of 5 average rating, 363 reviews
Top guest favourite
Flat in San Felipe

Casa del Horno | A Piece of Panamanian History

Enjoy a different experience in the center of the Old Town. Casa del Horno is a historic building created from the restoration of an old mid-19th century structure, which retains the character of its calicanto walls. Today, this space combines history, comfort and a very prime location. You will be surrounded by restaurants, cafes, and bars, and you will have very easy access to Panama's most iconic sites.

4.93 out of 5 average rating, 75 reviews
Guest favourite
Flat in Panama City

Modern studio with sea view / central / prime location

Enjoy a comfortable and modern stay in this fully equipped studio, located in The Sands Apartments & Mall, one of the most exclusive buildings on Avenida Balboa, facing the Coastal Belt and the sea. We have a contemporary design, excellent layout and floor-to-ceiling windows that offer plenty of natural light and spectacular views of the ocean and the city, creating a cozy and relaxing atmosphere.

4.96 out of 5 average rating, 28 reviews
Guest favourite
Home in Gamboa

BirdHouse — Gamboa, Panama Canal Rainforest

BirdHouse: Let's inhabit the space. Designed for people who want to experience the tropics, not shut them out. Open the screens, feel the breeze, listen to the rain, cool off in the pool, and wake to birds and howler monkeys. Located in historic Gamboa, BirdHouse is a place to slow down and experience one of the world’s richest tropical forests from the comfort of a thoughtfully designed home.

4.86 out of 5 average rating, 111 reviews
Guest favourite
Flat in Panama City

Modern, central and comfortable (001)

Modern and cozy studio in the heart of Panama. Perfect for exploring the Old Town, the Coastal Strip and more. Full kitchen, full bed, double sofa bed, air conditioning, fast WiFi and private bathroom. Ideal for 1–4 people. Private access, elevator and self check-in. Surrounded by restaurants, transportation, and tourist sites. Your ideal base to explore the city!

4.87 out of 5 average rating, 151 reviews

Popular amenities for Panama Canal holiday rentals