Holiday rentals in Muscatine

Relax at Simple Comforts Cottage

This nicely-appointed, edge-of-town little gem has lots to offer! Small town neighborhood in front; peaceful timber in the back. Perks of this darling are peace and quiet, leisurely shopping/dining, no crowds or traffic, and a safe, friendly-but-unobtrusive neighborhood. There’s lots here to make your stay comfortable: fully stocked kitchen, gas grill, firepit, electronic fireplace, ROKU TV, WIFI, on-site free private parking, dedicated work area, laundry, AC, and more – all the simple comforts!

La Casita Guest House

La Casita is a family freindly, fully remodeled 3 bedroom/2 bath home. We are located within a 3 minute drive to historical downtown Muscatine. The kitchen is fully equiped and the home features a king bed, a queen bed and a twin bed for use (a pack-n-play is available if requested). Other features include full tub/shower combos in each bathroom, full size washer & dryer, smoke/carbon monoxide detectors, self check in with keyless entry, wifi, smart TV, and an enclosed private backyard area.

Historic West Hill Retreat

Beautiful historic 4 bedroom, 4 bath home within walking distance to shopping, bars/restaurants and all that downtown Muscatine has to offer. Enjoy sweeping views of the Mississippi River from several vantage points in and outside this home. The 3000 sf interior offers many places to gather and relax. Two of the bedrooms have on suite full baths. The other two bedrooms share a full bath. Additional amenities include, fully equipped kitchen, laundry, games, grill, outdoor entertainment area.

Private & Modern. Near river and wildlife refuge!

Experience the outdoors in comfort from this modern cabin, situated next to the 2200 acre Princeton Wildlife Management Area, and the nearby Mississippi River. It is ranked as the most “Wish Listed” Iowa listing of 2025 on Airbnb. Are you into hiking, biking, fishing, hunting, boating, or other water, winter, and summer activities? This cabin can support it all! Sit back and relax on the large deck while enjoying a coffee & the local wildlife, flora, & fauna of the Mississippi Valley Region.

Farm stay close to Iowa City, IA

15 min.-Iowa City, 5 min- Riverside Casino, & 35 min-Eastern Iowa Airport, Cedar Rapids, IA. Comfy beds, living room sectional pulls out to queen hide a bed, 32 acres, horseback riding (sm. fee)*, winter fun, & fishing pond. First 2 guests pay base price, then 3rd thru 10th guests pay an extra 30.00 EACH. NO PARTIES on our farm. We live on property in a separate home. Dogs welcomed (must be kenneled when you leave property). We have an oven and cookware in kitchenette. *contact for details.

Shade Tree Farms in Letts, Iowa

Forget your worries in this spacious log home on 30 acres. Perfect for relaxing and renewing. Short drive to Muscatine with many historic sites, shops, unique restaurants. Near Grandview, Wapello, Letts, Columbus Junction with small town features and 35 miles from Iowa City. Mowed walking path around field. Exercise equipment. 2 car garage, 1 motorcycle garage. New pond. Privacy tucked into the field but just off the main highway. Sit and relax on massive front porch and watch the wildlife.

Helen's Henhouse

Welcome to the coziness of Helen's Henhouse, a lovingly restored 1890 home. Offering 4 cozy bedrooms, a delightful eat-in kitchen, an extra third-floor twin suite, and a generous living room featuring a dedicated work area, it's designed for retreats but perfect for any escape. Unleash your creativity in our well-equipped workspace, complete with 10 tables, design walls, a cutting station, and an ironing board. Your retreat, your way! A Retreat Haven for Every Stay. Unwind, Create, or Relax.

Downtown;Walk to Shops, Restaurants, Entertainment

Located in the heart of Downtown - Enjoy great views of historic downtown Muscatine. - Steps away from restaurants, pubs, museums, and shopping. - Two blocks away from Mississippi Riverfront. - Enjoy a walk or bike ride along the trail system. - 2 bedrooms - one King and one Queen bed - WiFi, Smart TV and charging stations - Secure, safe location There are stairs to climb to reach the loft, and there is no elevator, but the spectacular views of Downtown are worth it when you get there!

Buckman's Bed and Breakfast (5 Bedrooms+)

Enjoy the comfort and welcoming atmosphere of a home built to entertain family & friends. There are 5 guest bedrooms rooms: Room 1-King bed, sofa bed & recliner Room 2-Queen & sofa bed Room 3-Twin beds & convertible sofa Room 4-Queen & sofa bed Room 5-King & recliner Rooms 1,2 &5 have in suite bathrooms. Bathroom for room 4 is next door. Rooms 2 &3 share an inner door; ideal for parents with children. Breakfast is included. To book a room instead of the house, see separate listings.

Pearl of Mulberry

Welcome to the Pearl of Mulberry! This cozy and elite property is perfect for business travel, families or small groups. Centrally located in Muscatine, you can quickly and easily get to our beautiful downtown area as well as the soccer fields and sports dome. Enjoy the convenience of amenities during your stay with a fully equipped kitchen, outdoor grill and full size washer and dryer. The Pearl of Mulberry will help you feel at home while you're traveling in picturesque Muscatine.

Bridgeview home in Muscatine, Ia.

Relax with the whole family at this peaceful place to stay. A beautiful home that sits right on the edge of the Mississippi River along the train tracks in downtown Muscatine, right next to the bridge. Breathtaking views and house is right on the bike trail and is walking distance from the best restaurants and bars in town. Also has a big hot tub on the deck where you can relax with family and friends and enjoy the beautiful views overlooking the Mississippi River and bridge.😎

The Emerald Loft Apartment

Stay in a Historic District Downtown loft! River views. Nearby park, playground, bike trails, boat ramps & marina. Shopping, live music, & restaurants. Private entry with 1,000 sqr ft of space, open concept, full kitchen, TV, laundry, private bath, literally right in middle of everything. Check in at Creations by Oz "Jewelry, Wine, & Unique Finds". Enjoy a glass of wine upon check-in. Come hungry. Photo comments provide dining options within steps of the Emerald Room.