Holiday rentals with a patio in Florence County

Peaceful cabin retreat! Collins Quarters

In the middle of town, this unique place has a style all on its own. Inspired by Mountain Bungalows and Spanish accents, this one of a kind home sits directly beside MUSC in Florence SC. Close to everything you can possibly need, amenities include: 1 King bed, 1 Queen bed, 1 twin bed, 1 Full Size sofa bed, a full kitchen with living room and dining area, outdoor shower, and a nice sizable front porch to sit and sip your morning coffee looking over a beautiful landscaped front yard. Dog friendly!

The Hideaway at Fox Fields

The Hideaway at Fox Fields tiny home sleeps up to 4 with one bedroom and a sleeper sofa (both queen size beds). The bathroom has a walk-in shower. There's full kitchen with dishwasher, oven, microwave, and dishes, plus a washer/dryer combo. There's TV (guests use their own streaming accounts), game cabinet, and two mini-split AC units. The front porch overlooks a pond; cows are in the pasture at times. Located 10 minutes from I-20 Exit 137 and 5 minutes from The Cabin at Old Spur wedding venue.

The Equestrian Retreat I95/I20

Enjoy the perfect blend of comfort, convenience, and country charm at our newly 2026 built home just outside Florence, SC. Located on a peaceful 1/2 acre lot with beautiful countryside views, this spacious 1300 sq ft 3-bedroom, 2-bath home is ideal for overnight travelers, family vacations, work trips, or extended stays. 1.5 hour to Myrtle & just 5 minutes from Interstate 95 and Interstate 20, you'll enjoy quick and easy highway access while still experiencing the tranquility of rural living.

Cozy 2BR Near McLeod & MUSC | Pet-Friendly

Perfect for traveling professionals or vacationers, this 2BR/1BA home is quiet, comfortable and minutes from the heart of Florence. Enjoy fast Wi-Fi, on-site parking, and a fully furnished pet-friendly space in a layout ideal for solo travelers or shared stays. Unwind on the spacious front porch or private deck in a space set up to support your stay. The central location of this home and nearby amenities make it perfect for short stays or extended assignments. Please inquire about pet fees.

Cozy Florence Retreat Near Civic Center & I-95

Welcome to your Florence getaway! This bright, modern, and cozy Welcome to your Florence getaway! This bright, modern, and cozy home is perfectly located near I-95, Downtown Florence, the Florence Civic Center, and Darlington Raceway. Enjoy shopping and dining at nearby Buc-ee's, or take a short 1.5-hour drive to Myrtle Beach. The home features a fully equipped kitchen, comfortable bedrooms, and convenient parking—ideal for road trips, events, family stays, or a relaxing Southern escape.

Enchanting Treehouse with Modern Amenities

Perched on 20 acres along Catfish Creek, this enchanting tree house allows you to appreciate nature from a birds eye view. Whether it’s kayaking, canoeing, or exploring along the creek; relaxing in the hammocks and swings; engaging in a board game; or roasting marshmallows at the fire pit, Amenities include a full kitchen with full bath, outdoor shower, booth seating in dining table for up to 8, 2 bunk beds and loft style sleeping. Conveniently located 20 minutes from I-95.

Renovated 2 BR/2 B Townhouse Cozy & Clean

Keep it simple at this peaceful, centrally-located, and renovated townhouse close by I-95 and I-20 and within 15 mins. to the Florence Center, downtown Florence, many restaurants, and McLeod and MUSC Florence. House is located in a safe neighborhood. Enjoy being outdoors? Relax outdoors on your own private patio, go on a walk around the neighborhood, or go on an adventure. The Rail Trail & Ebenezer Park are minutes away. Utilities included.

Go With the Flo

Welcome to your cozy home in Florence! This 3-bedroom spot has a big fenced yard, a fully stocked kitchen, comfy beds, and fast WiFi. Kick back with a movie on the big TV or chill outside by the fire pit or under the covered outdoor lounge with its own TV. Pet-friendly, super close to MUSC & McLeod for traveling nurses, and just 15 mins from Buc-ee’s. Whether you’re here for work or play, you’ll feel right at home.

Modern 3BR/2BA Home in Lake City – Quiet & Central

Modern, clean 3BR/2BA home in quiet Lake City neighborhood—just minutes from shops, dining, and downtown. Each bedroom has a comfy bed, fresh linens, and a flat-screen TV. Kitchen includes basic cookware, utensils, and a Keurig with coffee pods. Enjoy free Wi-Fi, washer/dryer, and ample parking. Perfect for business, family, or a relaxing getaway. Centrally located and fully equipped for a comfortable stay!

Creekside Cottage - 4 Bedrooms

Enjoy your staying on this newly renovated Pet friendly house. Treat yourself with a cup of coffee at the deck while you watch your furry baby play in the big fenced backyard. This house is centrally located in Florence. Only minutes from downtown Florence, Grocery stores, Pharmacies, Restaurants, MUSC Hospital, McLeod Hospital. This house has two king bed bedrooms and two Queen bed bedrooms.

Cozy home in Florence, SC

Relax with the whole family at this peaceful place to stay, located in Florence, South Carolina. Places nearby: Francis Marion University - 5 mins Florence Regional Airport - 8 mins Florence County Museum and Timrod Park - 10 mins Jeffree Creeks Park - 13 mins Florence Veterans Park - 20 mins Marion County Museum - 25 mins Darlington Raceway - 30 mins

The Cozy Retreat at Governor’s Square @ I-20/I-95

Welcome to your home away from home! This newly renovated, private two-bedroom, 1.5-bath condo offers the perfect blend of comfort, convenience, and value—especially for extended stays, with discounted rates available for longer bookings.