Holiday rentals in East Syracuse

Three bedroom home near downtown, SU, & Lemoyne

This cozy, stylish home boasts modern amenities and historic charm. Originally a two-bed/one-bath 1922 bungalow, we've added a master bedroom suite that feels like an escape to a spa. The freshly remodeled three-bedroom, two-bathroom home is perfect for an extended stay with family, and just right for a weekend away with friends. Within walking distance to coffee, restaurants, and cute shops. A quick, ten-minute drive to Downtown Syracuse, Upstate University Hospital, and Syracuse University.

Anne's Place

Our place is conveniently located in a quiet and safe neighborhood just off the interstate - 10 minutes from Syracuse University, LeMoyne College, hospitals and downtown. It is just minutes away from Starbucks, Panera's, Wegmans and numerous other restaurants and shopping facilities. It is also very close to the Erie Canal trail (1/2 mile) for walking, jogging or biking. We have chosen to go with a farmhouse theme with our decor. We live next door and you will enjoy total privacy when you stay.

Luxury Loft|Laundry|DT Location|RemoteWork|Sleep 4

>>This newly constructed loft, is right around the corner from Pastabilities. Free street parking on Sun; Free from 6pm-9am the next day Mon-Sat *Garage parking at the Atrium ($14/night) Perfect location & walking distance to all downtown Syracuse attractions *Laundry in building *Sleeps 4 *King bed w/ queen pullout *Fully stocked w/ all you need *2 ROKU TVs *Enjoy 800sqft of space *Natural light from 10 windows *Perfect for business stays, festival stays, Syracuse U sports weekends #BookNow

Victorian Antique 1 Bdrm Ground Fl Apartment

1 Bedroom available 7min from downtown Syracuse. 3min from Destiny Mall, and Amtrak train/bus stations. This unit has an victorian style theme to it that showcases local art within the local area About 10 minutes from most areas of syracuse in every direction due to the central location and easy access to highways Keep in mind this is an inner city location it's safe but more of a working class neighborhood. There are security cameras around the property and off street parking in the back.

Designer's Sprawling Penthouse. 2BR, 2.5 BA PH

At the center of everything downtown, this massive designer Penthouse awaits. Elevator doors open at the top of the building directly onto a grand foyer and dedicated workspace. The 60 foot long gallery leads you past oversized sleeping rooms with ensuite bathrooms, a guest bathroom and laundry room. A great room lies beyond with chef's kitchen, dining area & living room featuring a double sided fireplace. Original artworks and custom furnishings create a comfortable luxurious environment.

SyracuseSpot-PoolTable/Traeger /Firepit /Cornhole

Are you looking have a comfortable stay with thoughtful and fun amenities? This is your SYRACUSE SPOT! 2025 remodel that's less than 10 minutes to a variety of Syracuse venues, hospitals and parks. Spread out and bring your family and friends (furry included) to our home and make it your own. Enjoy the fast internet, full coffee bar, snacks, and 4K TV's in every room! Our goal is to bring a high value option that provides a fun space unique to the market. We welcome you to CUSE!

Gracious 1920s Georgian close to hosp & colleges

The whole group will enjoy easy access to everything from this spacious, centrally located home. Close to SU, LeMoyne, ESF, St Joseph’s hospital, Crouse & Upstate. Enjoy the large kitchen and separate dining room, and relax in the living room. You can look forward to a great nights sleep in our 2- king beds in our master suites, or a full in the guest room. If you don’t require full use of the house, please let us know and we can adjust the cleaning fee prior to your booking.

Entire Modern Cozy 2BR Apt mins SU LeMoyne DT

Retro-inspired retreat with bold design, natural light, and a dedicated workspace—ideal for remote work or weekend stays. Conveniently located just minutes from key local destinations. Nearby Syracuse University & JMA Wireless Dome – ~2.5 miles / ~7 mins Le Moyne College – ~1.5 miles / ~5 mins Downtown -~3.4 miles / ~10 mins SUNY Upstate Medical University – ~3 miles / ~8 mins CNY Fertility Syracuse – ~3.4 miles / ~13 mins Syr Hancock Int'l Airport – ~4.2 miles / ~15 mins

Chic Comfort • Two Bedroom Apt

Relax in this bright, thoughtfully designed apartment featuring a cozy living area, stylish decor, and a dedicated workspace. Enjoy natural light and modern comfort. Minutes from downtown, Syracuse University, Destiny USA, and top hospitals. Features two bedrooms with comfy queen beds & a fully equipped kitchen. Perfect for business travelers, University visits, or weekend getaways. Just 12 minutes from the airport, with easy access to dining, shopping and entertainment.

Charming Boho Getaway

Welcome to your private 1st-floor retreat on Syracuse's Westside! Just minutes from Syracuse University, Destiny USA, Tipp Hill, and downtown, this charming boho-inspired space offers handcrafted wood details, heated floors in the bathroom, and modern amenities. Whether your 'e here for business or leisure, you'll enjoy a comfortable and convenient stay with everything the city has to offer right at your doorstep. Perfect for exploring or relaxing in style!

Affordable private basement apartment

My place is 10 min from Syracuse University, Upstate University hospital, Crouse Irving hospital, 5 min from LeMoyne College, 8 min from downtown Syracuse and St. Joeseph's Health hospital, 16 min from Green Lakes State Park... You’ll love my place because of the quaintness, the quiet and the proximity to what Syracuse has to offer. My place is good for couples, small families, solo adventurers, people with animals, and business travelers.

Syracuse Cozy Home Near SU & Destiny USA, Wi-Fi

Syracuse cozy, private, clean, and comfortable guesthouse in the Eastwood neighborhood. Ideally located just minutes from Syracuse University, downtown Syracuse, major hospitals, and top attractions. Enjoy fast WiFi, a fully equipped kitchen, free parking, self check-in, and complete privacy—perfect for business travelers, medical stays, families, and extended stays. A peaceful and convenient home away from home in Syracuse.