
Holiday rentals in East Prairie
Find and book unique accommodation on Airbnb
Top-rated holiday rentals in East Prairie
Guests agree: these stays are highly rated for location, cleanliness and more.

West End Hideaway•Pets•Fenced Yard•Queen Bed
This adorable West End gem is the perfect hideaway for a couples on the weekend, work trip or a small traveling family. This open floor plan features a gorgeous kitchen, cozy living space, two bedrooms with a queen bed and the second bedroom can be used as a workspace, or second bedroom with a memory foam futon mattress. Enjoy the privacy fenced in yard, and covered patio. It is so peaceful here, you won’t even realize you are minutes from the mall/downtown area. Washer/dryer Driveway park
5.0 out of 5 average rating, 4 reviews
Twisted Sassafras Treehouse
A custom-built treehouse located on 10 acres with a water view that you can take in from the hot tub on the deck! It is nestled high in the trees and is the perfect romantic getaway for two! Feel like you are away from it all without being away from it all! This treehouse is located on a county road just minutes from Cape Girardeau. Enjoy catch and release fishing on site, local wineries, shopping in historic downtown Cape Girardeau, local restaurants, gambling, historical sites & more!
5.0 out of 5 average rating, 216 reviews
The Hillandale Farmhouse 4 BR/3 BA Extended Stay
The Hillandale Farmhouse — single-level, ramp entry, room to breathe on a working Kentucky farm. Built for comfort, ease, and real living, this spacious home offers wide doorways and an accessible primary suite with a low-curb shower. The layout gives families and groups room to spread out, backed by a fully stocked kitchen, a washer and dryer near the main entrance, and ample truck and trailer parking for work crews, hunters, and longer stays. Any pets must be noted in the reservation.
5.0 out of 5 average rating, 18 reviews
Rivertown Getaway
Great location in the middle of town. Easy walk to the downtown area that offers great history on area with a museum & historic one room schoolhouse, take a walk along the beautiful Mississippi River, check out Veterans Park, etc., so much do to and see! This home can sleep 4 comfortably and accommodate 2 more guest with a blowup air mattress that is on site. Inside you will find new appliances, bedding, and linens. The outside is a work in progress! No smoking or pets allowed.
4.57 out of 5 average rating, 14 reviews
Under the Stars - Farmhouse
Enjoy the tranquility of this modern farmhouse charmer! Custom built minutes from downtown Cape. Relax outside around the fire pit, roast marshmallows and watch the sunset. Finish the night with a long soak in the hot tub. Start the morning on the front porch rocking chairs and take in a sunrise. Open concept, fully equipped kitchen, 3 Bd. including King master/full bath, 2 Queens with full guest bath. Near Trail of Tears and walking distance to classic dive bar/burger joint
4.94 out of 5 average rating, 287 reviews
The Hut II on Reelfoot Lake
The Hut II is a clean 3 bedroom 1 bathroom house with a full kitchen. Located right across from Reelfoot lake where you can sit on the porch and enjoy the beautiful view of the lake. Sleeping arrangements offer bedroom 1 with a full and twin bed, bedroom 2 with 2 twin beds and bedroom 3 with 2 twin beds. The Hut II offers parking in the front or a carport for parking in the back. So you can enjoy the comforts of home while enjoying a vacation at the lake or a fishing/hunting trip.
4.97 out of 5 average rating, 34 reviews
Modern Luxury Cabin, Fireplaces, Hot Tub Paducah
Shepherd’s Lantern Acres offers an unparalleled luxury retreat experience, featuring two cabins that seamlessly blend modern comfort with breathtaking natural beauty. Your cabin features unobstructed views of over 2 acres of seasonal wildflower meadows and pristine nature. Dogs are also welcome to enjoy their very own dog spa! With a beautiful master suite, well-appointed kitchen, and in unit laundry, we have ensured that all the comforts of home are at your fingertips.
5.0 out of 5 average rating, 33 reviews
Newly Renovated 3 Bedroom 2 Bath Home - Sleeps 9
Looking for a spacious and welcoming Airbnb in Sikeston? 🏡✨ This gorgeous, newly renovated 3 bedroom, 2 bathroom home is the ideal destination for unforgettable memories with your loved ones. The house sleeps up to 9 guests comfortably, making it perfect for families and groups. Conveniently located in a fantastic residential area, you're just moments away from local attractions, shopping, and dining spots.
4.97 out of 5 average rating, 31 reviews
Family Home near the MS River with a toy Room
The whole group will enjoy easy access to everything from this centrally located place. 3 blocks from the New Madrid boat ramp / levee. Less than 5 miles from HWY 55. Large family style home - on the first level - living room, dining room, kitchen, laundry room, guest bathroom, main bedroom and main bathroom. The upstairs has 2 bedrooms and a toy room with another full bathroom upstairs.
4.94 out of 5 average rating, 16 reviews
Emma’s Cottage
Take it easy at this unique and tranquil getaway. Emma’s cottage is located in the historic north end of Sikeston, just minutes away from the local hospital and power plant, which makes it a perfect place for traveling professionals and people coming into town to visit friends and family. This cottage is 2 bedrooms, 1 bathroom, with a queen bed and a full bed.
5.0 out of 5 average rating, 32 reviews
The Peery House at Springhill Farms
The Peery House is our family home-place, built circa 1900, transformed into a quaint Airbnb. It is located on our farm, Springhill Family Farms in Western KY and is a great place for someone looking to get away from the busyness of life, looking for rest and relaxation or just looking for a unique, little farmhouse while passing through the area.
4.99 out of 5 average rating, 211 reviews
THE DREAMCATCHER
Beautiful brick home with lake view and access to Reelfoot Lake (no ramp), paved drive with ample parking for boat / trailer, back deck with table and chairs, open space kitchen and den, perfect for group fishing trip, hunting trip, or just sight seeing, (area known for its large population of eagles), quiet neighborhood, peaceful place to stay.
4.99 out of 5 average rating, 157 reviewsPopular amenities for East Prairie holiday rentals
Other great holiday rentals in East Prairie

Glamping Double Domes on Private Lake & Hot Tub!
4.95 out of 5 average rating, 39 reviews
Quiet Country Farmhouse * Late Check-out *
5.0 out of 5 average rating, 68 reviews
tiny house. on the lake. log cabin
5.0 out of 5 average rating, 19 reviews
The Covenant Cabin at West Ridge Outdoor Resort
4.93 out of 5 average rating, 15 reviews
Runway Retreat
5.0 out of 5 average rating, 3 reviews
The Brooks Estate
4.8 out of 5 average rating, 5 reviews
Sunset Sanctuary
5.0 out of 5 average rating, 3 reviews
Farmer Ty’s ranch house from ‘Farmer Wants a Wife’
4.86 out of 5 average rating, 57 reviewsDestinations to explore
- Nashville Holiday rentals
- Indianapolis Holiday rentals
- St. Louis Holiday rentals
- Louisville Holiday rentals
- Memphis Holiday rentals
- Branson Holiday rentals
- Chattanooga Holiday rentals
- Birmingham Holiday rentals
- Hot Springs Holiday rentals
- Lexington Holiday rentals
- Bentonville Holiday rentals
- Springfield Holiday rentals





