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Places to stay near 21c Museum Hotel

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Top-rated holiday rentals near 21c Museum Hotel

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Guest favourite
The open living space features hardwood flooring and abundant natural light from large windows. A cozy seating area includes a gray couch and a blue ottoman, while a modern kitchen showcases granite countertops and stainless steel appliances. A small desk and stylish shelving enhance the room's functionality.
Loft in Downtown Durham

VIP Loft on Main St. - Center of downtown Durham!

Located in THE center of downtown Durham! Entrance on Main Street, completely surrounded by restaurants, shops, cafes and famous venues - but it's a historic brick building so this spacious loft is a quiet oasis above the hustle and bustle. Located on the 2nd floor above a restaurant and no neighbors above. You'll feel like a VIP while you look out of the giant windows over Main St! Complete with a comfortable King-size bed, cozy couch, 65" TV, and a stylish and modern kitchen and bathroom.

4.94 out of 5 average rating, 348 reviews
Guest favourite
A spacious living area features a sleek gas fireplace on one side, with modern artwork displayed on the walls. Comfortable seating includes a large gray sofa and green accent chairs, accompanied by a round coffee table. Natural light floods in through large windows.
Home in Durham

Modernist Masterpiece: 'Simply the Best'

Welcome to Hazel Modernist 6 - designed and built by Alicia Hylton-Daniel, with her "sister," Modernist 5, next door. Centrally located downtown, this gorgeous escape is truly livable. Fully equipped chefs kitchen opens into the large living & dining space, with Frame TV and fireplace. 3BR & private back deck offer plenty of space together or alone. Each home by Alicia is infused with creative and new design concepts. This glamorous home celebrates the essence of Tina Turner, Simply the Best.

4.96 out of 5 average rating, 112 reviews
Top guest favourite
Flat in Durham

2-BR apt/garden near downtown Durham arts & eats

A private, restful & artful 2-BR apt. hosted by one of fewer-than-20 Airbnb Belo Award winners in the world. 900 sq. ft. complete lower fl. of 1960s brick split-level on unpaved lane near park. Lush garden. Private entry; parking; lvng rm w/fireplace; bthrm/shwr; kitchenette only; generous amenities; wifi; TV. Superhost since 2014; 1,100+ 5-star reviews. 1 mi. DPAC/Durham Bulls; 1.5 mi. Carolina Theatre; 3 mi. Duke U/Med Cntr. No added cleaning fee. The dear furry ones do not enter the apt.

4.98 out of 5 average rating, 1183 reviews
Top guest favourite
The tiny farmhouse features a welcoming front porch with two yellow chairs and multiple entrance doors. A covered seating area with a fire pit and an outdoor dining table is positioned on the gravel surface, surrounded by a fenced yard and lush greenery.
Tiny home in Durham

Tiny Farmhouse in the Heart of Durham

Enjoy the tiny experience without sacrificing the relaxations and comforts of home. Unwind in this quaint 1 bedroom 1 bath tiny farmhouse that’s equipped with full-sized appliances and tasteful amenities. The Farmhouse at Scout is nestled in Downtown Durham’s burgeoning Southside neighborhood and is extremely close to the best restaurants, shops, and activities that Durham has to offer. Major attractions: • DPAC: .8 mi • Durham Bulls: .8 mi • Farmer’s Market: 1.2 mi • Duke: 2.9 mi

4.97 out of 5 average rating, 408 reviews
Top guest favourite
A spacious living area features large windows allowing natural light to fill the room. A round dining table sits in the foreground, while a sectional sofa and comfortable chairs create a relaxed seating arrangement. A sense of openness is enhanced by high ceilings and wooden flooring.
Flat in Downtown Durham

Downtown Durham Retreat

You’ll love this impeccable private downtown Durham apartment for the location, the views, the high ceilings & the luxurious master bedroom. 3rd floor unit in a renovated historic building. 3 blocks from Durham Performing Arts Center, Durham Bulls Athletic Park & the Amtrak station. 8 minute walk to Duke University West campus. Situated in the heart of the foodie paradise that IS downtown Durham. Ideal for 1-4 guests, business travelers, long-term stays welcome (kids 12+ please).

5.0 out of 5 average rating, 124 reviews
Top guest favourite
Home in Durham

Reclaimed Beauty in Downtown's Cleveland-Holloway

Stay in a renovated, simplified Queen Anne-style home from 1915, located on the edge of Durham's Cleveland Holloway neighborhood with easy access to downtown's farmers market, restaurants, and bars. A portion of your stay goes to Airbnb.org to support hosting refugees. Relax in a spacious kitchen with Little Waves coffee, high ceilings, a beautiful live edge slab table, and a luxurious clawfoot tub shower. Please note, there is only one bathroom located in the master bedroom.

4.95 out of 5 average rating, 356 reviews
Top guest favourite
A modern tiny house is nestled among lush greenery, featuring large windows that invite natural light. A wooden pathway leads to the entrance, surrounded by a variety of plants and trees, creating a serene and secluded atmosphere.
Tiny home in Durham

Modern Tiny House Near Duke & Downtown

You’ll feel like you’re getting away from it all in this modern, private tiny house in the trees, even though you’re just minutes from Duke, downtown Durham, shopping, and restaurants. It’s the perfect balance of peaceful retreat and city convenience. The home includes all the essentials — full kitchen, laundry, A/C, and high-speed internet — but many guests find themselves spending most of their time relaxing on the screened-in porch, listening to birds, and recharging.

4.96 out of 5 average rating, 652 reviews
Top guest favourite
A tiny house is depicted, featuring a bright blue exterior and a welcoming wooden deck. Surrounding trees provide shade, and a stone walkway leads to the entrance. The setting is lush with greenery, enhancing the serene atmosphere of the backyard escape.
Tiny home in Durham

Five & Dime Tiny House

Experience the charm of tiny living in this pet-friendly studio located in my serene yet urban backyard. It offers a peaceful escape while remaining convenient to the attractions & amenities that Durham has to offer. -only a mile east of downtown -1.5 miles to DPAC and Carolina Theatre -ten minutes to both Duke Hospital and Duke Regional -less than 20 minutes to RDU airport Let your dog run around the fully fenced yard while you sit on the deck and sip your coffee!

4.97 out of 5 average rating, 343 reviews
Guest favourite
Flat in Downtown Durham

100 Year-Old Historic Brick 2BR Loft |Large Patio2

Party Policy: To ensure a great experience for everyone, parties are not allowed. Violations of house rules such as excessive noise, smoking, or additional unapproved guests will result in a $300 fee, reservation cancellation, and removal from the property. If that works for you, please send an inquiry or instant book — we’d love to host you! Booking Requirement: Guests must have at least 3 reviews on their profile.

4.85 out of 5 average rating, 133 reviews
Guest favourite
A decorative pillow featuring two blue birds and a red heart is placed on a spacious bed. A cozy, textured throw blanket in neutral tones is draped nearby, contributing to a comfortable and inviting sleeping area.
Flat in Downtown Durham

Garden Oasis in the heart of downtown Durham

Beautifully renovated must stay if visiting Durham downtown. Within walking distance of many restaurants and city sites. Close to Duke Medical and Campus, and a stone's throw from many of the great restaurants and activities downtown has to offer. Pearl mill (122) offers a secret garden courtyard, an oasis of serenity amongst the action of the city. Huge pool to enjoy, March through October, weather permitting.

4.93 out of 5 average rating, 137 reviews
Guest favourite
A modern two-story townhome features a mix of blue siding and white trim, complemented by large windows that invite natural light. A small porch area is visible, along with a brick planter and surrounding greenery, enhancing the overall curb appeal.
Townhouse in Downtown Durham

Luxury Downtown Durham | 3BR | 5 Min Walk to DT

Experience the best of Durham from this modern 3-bedroom, 2.5 bath townhome in the historic Old Five Points neighborhood. Enjoy a stylish retreat with a fully equipped kitchen, smart home features, dedicated workspace, and comfortable living spaces—all minutes from Downtown Durham restaurants, breweries, DPAC, Durham Bulls Athletic Park, and Duke University.

4.97 out of 5 average rating, 138 reviews
Guest favourite
A compact bedroom features a spacious bed with muted bedding. A 48-inch LED TV is mounted on the wall, surrounded by ambient lighting in shades of blue and purple. A dresser and shelving unit provide storage, while double doors lead to additional space.
Flat in Downtown Durham

Clean Apartment Downtown Durham

Your family will be close to everything when you stay at this centrally-located place. Located on 6th floor with no neighbors above. You feel VIP while you look out the nice view from balcony over main st. Complete with a comfortable Queen -size bed with 48 inch led light tv in room. 65” led light TV, cozy couch and stylish and modern kitchen and bathroom

4.91 out of 5 average rating, 106 reviews

Popular amenities for holiday rentals near 21c Museum Hotel

KitchenWifiPoolFree parking on premisesAir conditioning

Other top sights near 21c Museum Hotel

Durham Performing Arts Center

402 locals recommend

Durham Bulls Athletic Park

371 locals recommend

American Tobacco Campus

201 locals recommend

Boxcar Bar Arcade

172 locals recommend

Durham Farmers' Market

149 locals recommend

Carolina Theatre

144 locals recommend

Apartment rentals with wifi

Superhost
A cozy living area features a blue sectional sofa, accented by decorative pillows. A wooden coffee table sits centrally on a colorful rug. Two lamps provide warm lighting, while an artwork depicting cattle complements the warm-toned wall. A TV is positioned on a black stand.
Apartment in Downtown Durham

Downtown "Bull Durham" Condo

4.8 out of 5 average rating, 348 reviews
Top guest favourite
A cozy living area features a leather couch adorned with a colorful throw blanket. A modern glass coffee table is positioned in front of the couch, complemented by a small dining area visible in the background, which includes a wooden table and decorative flowers.
Apartment in Raleigh

Cozy Village Condo Near Downtown and NC State

4.98 out of 5 average rating, 195 reviews
Guest favourite
A welcoming living area features a deep blue sectional sofa paired with a modern coffee table. The walls are painted in a soft pink hue, complemented by colorful artwork. A dining space with two chairs is visible, along with a kitchen area that includes essential appliances.
Apartment in Durham

Pet Friendly, Brand New Condo, Quiet, Green Space

4.92 out of 5 average rating, 105 reviews
Top guest favourite
A bright living room is furnished with comfortable sofas and accented by a colorful wall art piece. A wooden table with a lamp is positioned nearby, while natural light fills the space through window treatments. An upright piano is visible in the background.
Apartment in Carrboro

Carrboro/Chapel Hill/UNC bright contemporary condo

4.95 out of 5 average rating, 132 reviews
Top guest favourite
A cozy living area presents a neutral color palette featuring a pair of sofas with decorative pillows. A modern television is positioned on a white media console, while a decorative coffee table complements the space. Natural light fills the room through a nearby window.
Apartment in Cary

Lovely condo on the Greenway—near Raleigh

4.98 out of 5 average rating, 132 reviews
Top guest favourite
The living room features a modern design with a large flat-screen TV mounted on the wall. A comfortable sofa invites relaxation, while two accent chairs and a plush ottoman provide additional seating. Natural light filters through window blinds, complemented by decorative photographs on the wall.
Apartment in Raleigh

Condo in Village District near NC State & Downtown

4.95 out of 5 average rating, 247 reviews
Superhost
Apartment in Downtown Raleigh

A short walk with a breeze .

4.87 out of 5 average rating, 253 reviews
Guest favourite
A bright living area features a black pullout couch opposite a wooden coffee table. Two blue accent stools are placed nearby. Natural light filters through a large window with sheer curtains, and an artistic wall hanging displays two hands forming a heart.
Apartment in Raleigh

1 BR Condo in Cameron Village *Pet Friendly*

4.91 out of 5 average rating, 198 reviews

Family-friendly house rentals

Top guest favourite
Home in Durham

Stylish historic home—walk to Duke & 9th Street!

5.0 out of 5 average rating, 104 reviews
Top guest favourite
A single-story house features a black shingle roof and white siding, complemented by black shutters on the windows. A concrete driveway leads up to the front door, which is framed by a decorative glass panel. A grassy lawn surrounds the entrance, with a wooden fence in the background.
Home in Durham

Downtown Durham Area

4.99 out of 5 average rating, 162 reviews
Top guest favourite
Home in Durham

Duke Forest Zen Treehouse - pool table, decks

4.98 out of 5 average rating, 101 reviews
Guest favourite
The kitchen area features white cabinetry and a wooden countertop. A modern fridge is positioned next to the entrance door, leading to a cozy living area with a brown sofa and a bright red chair. A colorful wall art piece adds a touch of decoration.
Home in Durham

Clean Quiet Medical&Work Stay, Fenced Yard, Pets

4.9 out of 5 average rating, 242 reviews
Guest favourite
Home in Durham

5BR Durham Retreat | Movie Nights, Games & Gazebo

4.84 out of 5 average rating, 232 reviews
Guest favourite
A well-groomed dog stands on a wooden deck with a backdrop of lush greenery. Sunlight filters through the trees, creating a serene outdoor space. The deck features a blend of natural wood surfaces, complementing the relaxed atmosphere and inviting nature views.
Home in Durham

The Bird's Nest

4.9 out of 5 average rating, 490 reviews
Top guest favourite
The front view of a single-story house is presented, featuring a welcoming porch with white railings. A manicured lawn is framed by a gravel path leading to the entrance. Fenced areas and neighboring homes can be seen on either side, contributing to a peaceful suburban setting.
Home in Durham

Cozy Home in Downtown Durham.

4.93 out of 5 average rating, 107 reviews
Top guest favourite
A modern duplex with a welcoming front porch is showcased. The porch features wooden railings and potted plants on either side. A clear pathway leads to the entrance. The structure is set against a backdrop of trees and an expansive yard.
Home in Durham

Luxe Modern Retreat *Entire Duplex/ Both Units!*

4.93 out of 5 average rating, 179 reviews

Apartment rentals with air conditioning

Guest favourite
A modern kitchen with stainless steel appliances and granite countertops is showcased. A fan hangs from the ceiling, and a small shelving unit holds dishes. An archway leads to the living area, enhancing the open layout. Natural light illuminates the space.
Flat in Downtown Durham

Walk to Duke Campus! 1 Bedroom in Trinity Park!

4.85 out of 5 average rating, 162 reviews
Top guest favourite
A bright living room features a blue velvet sofa and two light blue chairs set around a glass coffee table. Soft carpeting covers the floor, with natural light streaming through the window blinds. Decorative elements include star-shaped wall art and a modern lamp.
Flat in Durham

Gorgeous Downtown Durham Retreat Sleeps 8

4.99 out of 5 average rating, 152 reviews
Top guest favourite
A comfortable living room features a sleek leather sofa accompanied by decorative pillows. A flat-screen TV is mounted on the wall opposite a dining area with a table and four chairs. Hardwood flooring and a ceiling fan add to the spacious and uncluttered atmosphere.
Flat in Durham

Sure Beats a Hotel -Walk to Duke/Dwntwn- King Bed

4.96 out of 5 average rating, 378 reviews
Guest favourite
Flat in Downtown Durham

Guest Favorite Studio | Walk to Duke & DT

4.93 out of 5 average rating, 125 reviews
Guest favourite
A well-lit bedroom features a spacious bed with a gray throw blanket. A modern desk and chair are situated near a window, while a full-length mirror is positioned against the wall. Soft natural light brightens the minimalistic decor of the room.
Flat in Downtown Durham

Bull City Apts near Downtown / Duke - Trinity 01

4.87 out of 5 average rating, 133 reviews
Guest favourite
A welcoming living space is presented with a comfortable gray sectional sofa accented by orange pillows. A wood coffee table and two armchairs are arranged on a patterned area rug. A television is mounted on a light wood stand, and large windows allow natural light to fill the area.
Flat in Durham

The Loft @ Casa Azul - Studio Apartment

4.92 out of 5 average rating, 130 reviews
Guest favourite
Flat in Durham

Lakewood/Lyon Park Renovated Cottage Near Duke 23A

4.8 out of 5 average rating, 106 reviews
Top guest favourite
Flat in Downtown Durham

Back Alley Apartment, walk Downtown and Duke.

4.97 out of 5 average rating, 180 reviews

Other great holiday rentals near 21c Museum Hotel

Top guest favourite
Guest suite in Durham

Private Sunny Suite- Walk to Downtown

4.93 out of 5 average rating, 254 reviews
Guest favourite
A light-filled living area is showcased with large windows that offer views of greenery. A modern sofa adorned with colorful throw pillows is complemented by a round coffee table on a patterned area rug. The kitchen, featuring turquoise cabinetry, is visible in the background.
Guest house in Downtown Durham

Duplex filled with natural light

4.93 out of 5 average rating, 153 reviews
Top guest favourite
A spacious living area features large glass walls allowing natural light and views of surrounding trees. A unique wood coffee table is centered on a light rug. Two comfortable sofas provide seating, paired with a modern lamp and elegant decor.
Home in Raleigh

Luxurious Modernist Tree House

4.96 out of 5 average rating, 204 reviews
Top guest favourite
A modern kitchen features vibrant turquoise cabinetry paired with neutral countertops. Stainless steel appliances, including a refrigerator and stove, are present. A small table with two bar stools occupies one corner, while a window allows natural light to fill the space.
Guest house in Durham

Modern Cottage With a Vintage Twist Near Downtown

4.96 out of 5 average rating, 399 reviews
Top guest favourite
A living area features a blue wall complemented by white trim. A plush blue sofa with orange cushions sits alongside two brown armchairs. A round black coffee table occupies the center of the space, layered over a green and orange area rug. Natural light streams through the stylish window treatments.
Bungalow in Durham

The Durham Blue Bungalow- Walk Downtown

4.99 out of 5 average rating, 129 reviews
Top guest favourite
A tree-lined gravel path winds through a lush landscape, bordered by a wooden fence. Tall trees provide shade, creating a tranquil atmosphere. The green grass and vibrant foliage reflect a peaceful rural setting at the horse farm.
Farm stay in Durham

Beautiful Farm stay 2 beds, 2 baths with office

4.98 out of 5 average rating, 344 reviews
Top guest favourite
A living area features two orange chairs and a gray sofa, complemented by a round coffee table and a woven accent chair. Light flows through a large window draped with sheer curtains, illuminating the neutral walls and area rug with geometric patterns.
Bungalow in Durham

Midcentury Modern, Near Duke

4.98 out of 5 average rating, 137 reviews
Guest favourite
Flat in Downtown Durham

Entertainment Central Park, Downtown, Unit B

4.97 out of 5 average rating, 98 reviews